Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies

A. Inguanzo, K. Poulakis, R. Mohanty, CG. Schwarz, SA. Przybelski, P. Diaz-Galvan, VJ. Lowe, BF. Boeve, AW. Lemstra, M. van de Beek, W. van der Flier, F. Barkhof, F. Blanc, P. Loureiro de Sousa, N. Philippi, B. Cretin, C. Demuynck, Z. Nedelska,...

. 2023 ; 9 (1) : 5. [pub] 20230120

Status not-indexed Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc23003124

Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23003124
003      
CZ-PrNML
005      
20230421100147.0
007      
ta
008      
230413s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41531-023-00448-6 $2 doi
035    __
$a (PubMed)36670121
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Inguanzo, Anna $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden $u Medical Psychology Unit, Institute of Neurosciences, University of Barcelona, Barcelona, Spain $u Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain $1 https://orcid.org/0000000308795875
245    10
$a MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies / $c A. Inguanzo, K. Poulakis, R. Mohanty, CG. Schwarz, SA. Przybelski, P. Diaz-Galvan, VJ. Lowe, BF. Boeve, AW. Lemstra, M. van de Beek, W. van der Flier, F. Barkhof, F. Blanc, P. Loureiro de Sousa, N. Philippi, B. Cretin, C. Demuynck, Z. Nedelska, J. Hort, B. Segura, C. Junque, K. Oppedal, D. Aarsland, E. Westman, K. Kantarci, D. Ferreira
520    9_
$a Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Poulakis, Konstantinos $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden $1 https://orcid.org/0000000266008086
700    1_
$a Mohanty, Rosaleena $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Schwarz, Christopher G $u Department of Radiology, Mayo Clinic, Rochester, MN, US $1 https://orcid.org/0000000214668357
700    1_
$a Przybelski, Scott A $u Quantitative Health Sciences, Mayo Clinic, Rochester, MN, US
700    1_
$a Diaz-Galvan, Patricia $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden $u Department of Radiology, Mayo Clinic, Rochester, MN, US $1 https://orcid.org/0000000161555585
700    1_
$a Lowe, Val J $u Department of Radiology, Mayo Clinic, Rochester, MN, US
700    1_
$a Boeve, Bradley F $u Department of Radiology, Mayo Clinic, Rochester, MN, US $1 https://orcid.org/0000000241538187
700    1_
$a Lemstra, Afina W $u Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
700    1_
$a van de Beek, Marleen $u Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
700    1_
$a van der Flier, Wiesje $u Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands
700    1_
$a Barkhof, Frederik $u Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, Netherlands $u UCL institutes of neurology and center for medical image computing, London, UK
700    1_
$a Blanc, Frederic $u Day Hospital of Geriatrics, Memory Resource and Research Center (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, Strasbourg, France $u University of Strasbourg and French National Center for Scientific Research (CNRS), ICube Laboratory and Federation de Medecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Integrative en Sante (IMIS)/ICONE, Strasbourg, France
700    1_
$a Loureiro de Sousa, Paulo $u Day Hospital of Geriatrics, Memory Resource and Research Center (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, Strasbourg, France $u University of Strasbourg and French National Center for Scientific Research (CNRS), ICube Laboratory and Federation de Medecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Integrative en Sante (IMIS)/ICONE, Strasbourg, France
700    1_
$a Philippi, Nathalie $u Day Hospital of Geriatrics, Memory Resource and Research Center (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, Strasbourg, France $u University of Strasbourg and French National Center for Scientific Research (CNRS), ICube Laboratory and Federation de Medecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Integrative en Sante (IMIS)/ICONE, Strasbourg, France $1 https://orcid.org/0000000264839222
700    1_
$a Cretin, Benjamin $u Day Hospital of Geriatrics, Memory Resource and Research Center (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, Strasbourg, France $u University of Strasbourg and French National Center for Scientific Research (CNRS), ICube Laboratory and Federation de Medecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Integrative en Sante (IMIS)/ICONE, Strasbourg, France
700    1_
$a Demuynck, Catherine $u Day Hospital of Geriatrics, Memory Resource and Research Center (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, Strasbourg, France $u University of Strasbourg and French National Center for Scientific Research (CNRS), ICube Laboratory and Federation de Medecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Integrative en Sante (IMIS)/ICONE, Strasbourg, France
700    1_
$a Nedelska, Zuzana $u Department of Radiology, Mayo Clinic, Rochester, MN, US $u Department of Neurology, Charles University, 2nd Faculty of Medicine, Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Annes University Hospital Brno, Brno, Czech Republic $1 https://orcid.org/0000000232692115
700    1_
$a Hort, Jakub $u Department of Neurology, Charles University, 2nd Faculty of Medicine, Motol University Hospital, Prague, Czech Republic $u International Clinical Research Center, St. Annes University Hospital Brno, Brno, Czech Republic
700    1_
$a Segura, Barbara $u Medical Psychology Unit, Institute of Neurosciences, University of Barcelona, Barcelona, Spain $u Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain $1 https://orcid.org/0000000296735479
700    1_
$a Junque, Carme $u Medical Psychology Unit, Institute of Neurosciences, University of Barcelona, Barcelona, Spain $u Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain
700    1_
$a Oppedal, Ketil $u Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway $u Stavanger Medical Imaging Laboratory (SMIL), Department of Radiology, Stavanger University Hospital, Stavanger, Norway $u Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway
700    1_
$a Aarsland, Dag $u Department of Neuroimaging, Center for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK $1 https://orcid.org/000000016314216X
700    1_
$a Westman, Eric $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden $u Department of Neuroimaging, Center for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK $1 https://orcid.org/0000000231152977
700    1_
$a Kantarci, Kejal $u Department of Radiology, Mayo Clinic, Rochester, MN, US
700    1_
$a Ferreira, Daniel $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden. daniel.ferreira.padilla@ki.se $u Department of Radiology, Mayo Clinic, Rochester, MN, US. daniel.ferreira.padilla@ki.se $1 https://orcid.org/0000000195224338
773    0_
$w MED00208625 $t NPJ Parkinson's disease $x 2373-8057 $g Roč. 9, č. 1 (2023), s. 5
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36670121 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230413 $b ABA008
991    __
$a 20230421100140 $b ABA008
999    __
$a ok $b bmc $g 1922779 $s 1189331
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 9 $c 1 $d 5 $e 20230120 $i 2373-8057 $m NPJ Parkinson's disease $n NPJ Parkinsons Dis $x MED00208625
LZP    __
$a Pubmed-20230413

Find record

Citation metrics

Archiving options