Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Modeling sepsis, with a special focus on large animal models of porcine peritonitis and bacteremia

P. Vintrych, M. Al-Obeidallah, J. Horák, J. Chvojka, L. Valešová, L. Nalos, D. Jarkovská, M. Matějovič, M. Štengl

. 2022 ; 13 (-) : 1094199. [pub] 20230110

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc23003183

Infectious diseases, which often result in deadly sepsis or septic shock, represent a major global health problem. For understanding the pathophysiology of sepsis and developing new treatment strategies, reliable and clinically relevant animal models of the disease are necessary. In this review, two large animal (porcine) models of sepsis induced by either peritonitis or bacteremia are introduced and their strong and weak points are discussed in the context of clinical relevance and other animal models of sepsis, with a special focus on cardiovascular and immune systems, experimental design, and monitoring. Especially for testing new therapeutic strategies, the large animal (porcine) models represent a more clinically relevant alternative to small animal models, and the findings obtained in small animal (transgenic) models should be verified in these clinically relevant large animal models before translation to the clinical level.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23003183
003      
CZ-PrNML
005      
20250211103714.0
007      
ta
008      
230413e20230110sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fphys.2022.1094199 $2 doi
035    __
$a (PubMed)36703923
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Vintrych, Pavel $u Department of Cardiology, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
245    10
$a Modeling sepsis, with a special focus on large animal models of porcine peritonitis and bacteremia / $c P. Vintrych, M. Al-Obeidallah, J. Horák, J. Chvojka, L. Valešová, L. Nalos, D. Jarkovská, M. Matějovič, M. Štengl
520    9_
$a Infectious diseases, which often result in deadly sepsis or septic shock, represent a major global health problem. For understanding the pathophysiology of sepsis and developing new treatment strategies, reliable and clinically relevant animal models of the disease are necessary. In this review, two large animal (porcine) models of sepsis induced by either peritonitis or bacteremia are introduced and their strong and weak points are discussed in the context of clinical relevance and other animal models of sepsis, with a special focus on cardiovascular and immune systems, experimental design, and monitoring. Especially for testing new therapeutic strategies, the large animal (porcine) models represent a more clinically relevant alternative to small animal models, and the findings obtained in small animal (transgenic) models should be verified in these clinically relevant large animal models before translation to the clinical level.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Al-Obeidallah, Mahmoud $u Department of Physiology, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
700    1_
$a Horák, Jan $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
700    1_
$a Chvojka, Jiří $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
700    1_
$a Valešová, Lenka $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $7 xx0328736
700    1_
$a Nalos, Lukáš $u Department of Physiology, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
700    1_
$a Jarkovská, Dagmar $u Department of Physiology, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
700    1_
$a Matějovič, Martin $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
700    1_
$a Štengl, Milan $u Department of Physiology, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czechia
773    0_
$w MED00174601 $t Frontiers in physiology $x 1664-042X $g Roč. 13 (20230110), s. 1094199
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36703923 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230413 $b ABA008
991    __
$a 20250211103711 $b ABA008
999    __
$a ok $b bmc $g 1922807 $s 1189390
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2022 $b 13 $c - $d 1094199 $e 20230110 $i 1664-042X $m Frontiers in physiology $n Front. physiol. $x MED00174601
LZP    __
$a Pubmed-20230413

Najít záznam

Citační ukazatele

Možnosti archivace