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Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge
A. Rodríguez-Carrillo, V. Mustieles, E. Salamanca-Fernández, A. Olivas-Martínez, B. Suárez, L. Bajard, K. Baken, L. Blaha, EC. Bonefeld-Jørgensen, S. Couderq, SC. D'Cruz, JB. Fini, E. Govarts, C. Gundacker, AF. Hernández, M. Lacasaña, F. Laguzzi,...
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
- MeSH
- biologické markery MeSH
- biologický monitoring * MeSH
- lidé MeSH
- mladiství MeSH
- monitorování životního prostředí metody MeSH
- mozkový neurotrofický faktor * MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Human biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are suspected to contribute to adverse health outcomes such as reproductive, neurological, and metabolic disorders, among other developmental and chronic impairments. One of the objectives of the H2020 European Human Biomonitoring Initiative (HBM4EU) was the development of informative effect biomarkers for application in a more systematic and harmonized way in large-scale European HBM studies. The inclusion of effect biomarkers would complement exposure data with mechanistically-based information on early and late adverse effects. For this purpose, a stepwise strategy was developed to identify and implement a panel of validated effect biomarkers in European HBM studies. This work offers an overview of the complete procedure followed, from comprehensive literature search strategies, selection of criteria for effect biomarkers and their classification and prioritization, based on toxicological data and adverse outcomes, to pilot studies for their analytical, physiological, and epidemiological validation. We present the example of one study that demonstrated the mediating role of the effect biomarker status of brain-derived neurotrophic factor BDNF in the longitudinal association between infant bisphenol A (BPA) exposure and behavioral function in adolescence. A panel of effect biomarkers has been implemented in the HBM4EU Aligned Studies as main outcomes, including traditional oxidative stress, reproductive, and thyroid hormone biomarkers. Novel biomarkers of effect, such as DNA methylation status of BDNF and kisspeptin (KISS) genes were also evaluated as molecular markers of neurological and reproductive health, respectively. A panel of effect biomarkers has also been applied in HBM4EU occupational studies, such as micronucleus analysis in lymphocytes and reticulocytes, whole blood comet assay, and malondialdehyde, 8-oxo-2'-deoxyguanosine and untargeted metabolomic profile in urine, to investigate, for example, biological changes in response to hexavalent chromium Cr(VI) exposure. The use of effect biomarkers in HBM4EU has demonstrated their ability to detect early biological effects of chemical exposure and to identify subgroups that are at higher risk. The roadmap developed in HBM4EU confirms the utility of effect biomarkers, and support one of the main objectives of HBM research, which is to link exposure biomarkers to mechanistically validated effect and susceptibility biomarkers in order to better understand the public health implications of human exposure to environmental chemicals.
Biomedical Research Center 18012 Granada Spain
Consortium for Biomedical Research in Epidemiology and Public Health Spain
Department of Biomedical Sciences and Toxicological Center University of Antwerp Belgium
Department of Environmental Health Norwegian Institute of Public Health Oslo Norway
Department of Legal Medicine and Toxicology University of Granada School of Medicine Granada Spain
Environment Agency Austria Vienna Austria
European University Cyprus Nicosia Cyprus
German Federal Institute for Risk Assessment Max Dohrn Straße 8 10 10589 Berlin Germany
Greenland Centre for Health Research University of Greenland Nuuk Greenland
Institute of Environmental Medicine Karolinska Institute Stockholm Sweden
National Food Institute Technical University of Denmark 2800 Kgs Lyngby Denmark
RECETOX Faculty of Science Masaryk University Kamenice 5 CZ62500 Brno Czech Republic
The National Research Centre for the Working Environment Copenhagen Denmark
Univ Rennes EHESP Inserm Irset UMR_S 1085 F 35000 Rennes France
VITO Health Flemish Institute for Technological Research Mol Belgium
Citace poskytuje Crossref.org
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