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Allergen immunotherapy for allergic asthma: The future seems bright
Z. Diamant, M. van Maaren, A. Muraro, M. Jesenak, I. Striz
Language English Country England, Great Britain
Document type Review, Journal Article
- MeSH
- Allergens MeSH
- Rhinitis, Allergic * drug therapy MeSH
- Antigens, Dermatophagoides therapeutic use MeSH
- Asthma * etiology MeSH
- Desensitization, Immunologic MeSH
- Humans MeSH
- Pollen MeSH
- Pyroglyphidae MeSH
- Sublingual Immunotherapy * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term effectiveness of house dust mite (HDM) AIT in a large group of patients with HDM-driven asthma further underscored its unique therapeutic potential as well as confirmed previous data with pollen AIT. More widespread use of this causal treatment in select patient populations should further move this promising therapeutic field. In this mini-review, we discuss updates on new insights based on real world patient data.
Dept Clin Pharm and Pharmacol Univ Groningen Univ Med Ctr Groningen Groningen Netherlands
Dept of Microbiology Immunology and Transplantation KU Leuven Catholic University of Leuven Belgium
Food Allergy Referral Centre Padua University Hospital Padua Italy
References provided by Crossref.org
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- $a Diamant, Zuzana $u Dept of Microbiology Immunology & Transplantation, KU Leuven, Catholic University of Leuven, Belgium; Dept of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden; Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic; Dept Clin Pharm & Pharmacol, Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands. Electronic address: z.diamant@4gems.nl
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- $a Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term effectiveness of house dust mite (HDM) AIT in a large group of patients with HDM-driven asthma further underscored its unique therapeutic potential as well as confirmed previous data with pollen AIT. More widespread use of this causal treatment in select patient populations should further move this promising therapeutic field. In this mini-review, we discuss updates on new insights based on real world patient data.
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