Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease

M. Valis, A. Dlabkova, J. Hort, F. Angelucci, J. Pejchal, K. Kuca, Z. Pavelek, JZ. Karasova, M. Novotny

. 2023 ; 159 (-) : 114223. [pub] 20230109

Jazyk angličtina Země Francie

Typ dokumentu randomizované kontrolované studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23003977

BACKGROUND: The acetylcholinesterase inhibitor donepezil is administered as a treatment for Alzheimer's disease (AD). However, the appropriate donepezil dosage is still a matter of debate. METHODS: Forty AD patients receiving 10 mg/day of donepezil were randomly divided into four groups based on the time of plasma and cerebrospinal fluid (CSF) sampling: 6 h (n = 5), 12 h (n = 12), 18 h (n = 6) and 24 h (n = 17) after donepezil administration. High-performance liquid chromatography measured the donepezil concentration in plasma samples and CSF samples collected at 4-time points. RESULTS: Plasma and CSF levels among the groups were not significantly different. Conversely, the CSF/plasma donepezil concentration ratio considerably increased in the 24 h group compared to the 6 h (p < 0.005) and 12 h (p < 0.05) groups. CONCLUSION: The measurement of the CSF/plasma donepezil concentration ratio could be used to better evaluate the optimal dose of donepezil.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23003977
003      
CZ-PrNML
005      
20230425141022.0
007      
ta
008      
230418s2023 fr f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.biopha.2023.114223 $2 doi
035    __
$a (PubMed)36630846
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a fr
100    1_
$a Valis, Martin $u Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. Electronic address: martin.valis@fnhk.cz
245    14
$a The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease / $c M. Valis, A. Dlabkova, J. Hort, F. Angelucci, J. Pejchal, K. Kuca, Z. Pavelek, JZ. Karasova, M. Novotny
520    9_
$a BACKGROUND: The acetylcholinesterase inhibitor donepezil is administered as a treatment for Alzheimer's disease (AD). However, the appropriate donepezil dosage is still a matter of debate. METHODS: Forty AD patients receiving 10 mg/day of donepezil were randomly divided into four groups based on the time of plasma and cerebrospinal fluid (CSF) sampling: 6 h (n = 5), 12 h (n = 12), 18 h (n = 6) and 24 h (n = 17) after donepezil administration. High-performance liquid chromatography measured the donepezil concentration in plasma samples and CSF samples collected at 4-time points. RESULTS: Plasma and CSF levels among the groups were not significantly different. Conversely, the CSF/plasma donepezil concentration ratio considerably increased in the 24 h group compared to the 6 h (p < 0.005) and 12 h (p < 0.05) groups. CONCLUSION: The measurement of the CSF/plasma donepezil concentration ratio could be used to better evaluate the optimal dose of donepezil.
650    _2
$a lidé $7 D006801
650    _2
$a acetylcholinesterasa $7 D000110
650    12
$a Alzheimerova nemoc $x krev $x mozkomíšní mok $x farmakoterapie $7 D000544
650    12
$a cholinesterasové inhibitory $x krev $x mozkomíšní mok $x terapeutické užití $7 D002800
650    12
$a donepezil $x krev $x mozkomíšní mok $x terapeutické užití $7 D000077265
650    _2
$a indany $x terapeutické užití $x farmakologie $7 D007189
650    _2
$a piperidiny $x farmakologie $7 D010880
655    _2
$a randomizované kontrolované studie $7 D016449
655    _2
$a časopisecké články $7 D016428
700    1_
$a Dlabkova, Alzbeta $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defense in Brno, Hradec Kralove, Czech Republic. Electronic address: alzbeta.dlabkova@unob.cz
700    1_
$a Hort, Jakub $u Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address: jakub.hort@gmail.com
700    1_
$a Angelucci, Francesco $u Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Pejchal, Jaroslav $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defense in Brno, Hradec Kralove, Czech Republic
700    1_
$a Kuca, Kamil $u Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Electronic address: kamil.kuca@fnhk.cz
700    1_
$a Pavelek, Zbysek $u Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
700    1_
$a Karasova, Jana Zdarova $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, the University of Defense in Brno, Hradec Kralove, Czech Republic; Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
700    1_
$a Novotny, Michal $u Department of Neurology, Faculty of Medicine and University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. Electronic address: m.novas82@gmail.com
773    0_
$w MED00005486 $t Biomedicine & pharmacotherapy Biomedecine & pharmacotherapie $x 1950-6007 $g Roč. 159, č. - (2023), s. 114223
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36630846 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230418 $b ABA008
991    __
$a 20230425141019 $b ABA008
999    __
$a ok $b bmc $g 1924565 $s 1190186
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 159 $c - $d 114223 $e 20230109 $i 1950-6007 $m Biomedicine & pharmacotherapy $n Biomed Pharmacother $x MED00005486
LZP    __
$a Pubmed-20230418

Najít záznam

Citační ukazatele

Možnosti archivace