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Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
I. Ottenbros, E. Lebret, C. Huber, A. Lommen, JP. Antignac, P. Čupr, L. Šulc, O. Mikeš, T. Szigeti, S. Középesy, I. Martinsone, Z. Martinsone, L. Akulova, O. Pardo, SF. Fernández, C. Coscollá, S. Pedraza-Diaz, M. Krauss, L. Debrauwer, K. Wagner,...
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
- MeSH
- biologické markery MeSH
- chlorprofam MeSH
- dospělí MeSH
- lidé MeSH
- pesticidy * moč MeSH
- vystavení vlivu životního prostředí analýza MeSH
- zemědělství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Geografické názvy
- Evropa MeSH
Humans are exposed to a mixture of pesticides through diet as well as through the environment. We conducted a suspect-screening based study to describe the probability of (concomitant) exposure to a set of pesticide profiles in five European countries (Latvia, Hungary, Czech Republic, Spain and the Netherlands). We explored whether living in an agricultural area (compared to living in a peri-urban area), being a a child (compared to being an adult), and the season in which the urine sample was collected had an impact on the probability of detection of pesticides (-metabolites). In total 2088 urine samples were collected from 1050 participants (525 parent-child pairs) and analyzed through harmonized suspect screening by five different laboratories. Fourty pesticide biomarkers (either pesticide metabolites or the parent pesticides as such) relating to 29 pesticides were identified at high levels of confidence in samples across all study sites. Most frequently detected were biomarkers related to the parent pesticides acetamiprid and chlorpropham. Other biomarkers with high detection rates in at least four countries related to the parent pesticides boscalid, fludioxonil, pirimiphos-methyl, pyrimethanil, clothianidin, fluazifop and propamocarb. In 84% of the samples at least two different pesticides were detected. The median number of detected pesticides in the urine samples was 3, and the maximum was 13 pesticides detected in a single sample. The most frequently co-occurring substances were acetamiprid with chlorpropham (in 62 urine samples), and acetamiprid with tebuconazole (30 samples). Some variation in the probability of detection of pesticides (-metabolites) was observed with living in an agricultural area or season of urine sampling, though no consistent patterns were observed. We did observe differences in the probability of detection of a pesticide (metabolite) among children compared to adults, suggesting a different exposure and/or elimination patterns between adults and children. This survey demonstrates the feasibility of conducting a harmonized pan-European sample collection, combined with suspect screening to provide insight in the presence of exposure to pesticide mixtures in the European population, including agricultural areas. Future improvements could come from improved (harmonized) quantification of pesticide levels.
Institute of Risk Assessment Sciences Utrecht University Yalelaan 2 3584CM Utrecht the Netherlands
Laboratory of Hygiene and Occupational Diseases Rīga Stradiņš University Latvia
National Centre for Environmental Health Instituto de Salud Carlos 3 Majadahonda Spain
National Public Health Center Albert Flórián út 2 6 1097 Budapest Hungary
Oniris INRAE LABERCA 44300 Nantes France
RECETOX Faculty of Science Masaryk University Kotlarska 2 Brno 61137 Czech Republic
Citace poskytuje Crossref.org
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