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Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2
O. Tsyklauri, T. Chadimova, V. Niederlova, J. Kovarova, J. Michalik, I. Malatova, S. Janusova, O. Ivashchenko, H. Rossez, A. Drobek, H. Vecerova, V. Galati, M. Kovar, O. Stepanek
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
FunDiT
European Research Council - International
NLK
Directory of Open Access Journals
od 2013
Free Medical Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2012-01-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2013-01-01
Health & Medicine (ProQuest)
od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
36705564
DOI
10.7554/elife.79342
Knihovny.cz E-zdroje
- MeSH
- CD8-pozitivní T-lymfocyty MeSH
- diabetes mellitus 1. typu * patologie MeSH
- imunologická tolerance MeSH
- interleukin-2 MeSH
- lektinové receptory NK-buněk - podrodina K MeSH
- lidé MeSH
- myši MeSH
- receptory interleukinu-7 MeSH
- regulační T-lymfocyty * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity. In this study, we identified that Tregs increase the quorum of self-reactive CD8+ T cells required for the induction of experimental autoimmune diabetes in mice. Their major suppression mechanism is limiting available IL-2, an essential T-cell cytokine. Specifically, Tregs inhibit the formation of a previously uncharacterized subset of antigen-stimulated KLRK1+ IL-7R+ (KILR) CD8+ effector T cells, which are distinct from conventional effector CD8+ T cells. KILR CD8+ T cells show superior cell-killing abilities in vivo. The administration of agonistic IL-2 immunocomplexes phenocopies the absence of Tregs, i.e., it induces KILR CD8+ T cells, promotes autoimmunity, and enhances antitumor responses in mice. Counterparts of KILR CD8+ T cells were found in the human blood, revealing them as a potential target for immunotherapy.
Department of Biomedicine University Hospital of Basel Basel Switzerland
Faculty of Science Charles University Prague Czech Republic
Institute of Microbiology of the Czech Academy of Sciences Prague Czech Republic
Citace poskytuje Crossref.org
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