-
Je něco špatně v tomto záznamu ?
Association of Hospital Surgical Volume With Survival in Early-Stage Cervical Cancer Treated With Radical Hysterectomy
N. Bizzarri, L. Dostálek, LRCW. van Lonkhuijzen, D. Giannarelli, A. Lopez, H. Falconer, D. Querleu, A. Ayhan, SH. Kim, DI. Ortiz, J. Klat, F. Landoni, J. Rodriguez, R. Manchanda, J. Kosťun, PT. Ramirez, MM. Meydanli, D. Odetto, R. Laky, I....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
- MeSH
- hysterektomie metody MeSH
- lidé MeSH
- nádory děložního čípku * patologie MeSH
- nemocnice MeSH
- přežití bez známek nemoci MeSH
- retrospektivní studie MeSH
- staging nádorů MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVE: To evaluate the association of number of radical hysterectomies performed per year in each center with disease-free survival and overall survival. METHODS: We conducted an international, multicenter, retrospective study of patients previously included in the Surveillance in Cervical Cancer collaborative studies. Individuals with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB1-IIA1 cervical cancer who underwent radical hysterectomy and had negative lymph nodes at final histology were included. Patients were treated at referral centers for gynecologic oncology according to updated national and international guidelines. Optimal cutoffs for surgical volume were identified using an unadjusted Cox proportional hazard model, with disease-free survival as the outcome and defined as the value that minimizes the P-value of the split in groups in terms of disease-free survival. Propensity score matching was used to create statistically similar cohorts at baseline. RESULTS: A total of 2,157 patients were initially included. The two most significant cutoffs for surgical volume were identified at seven and 17 surgical procedures, dividing the entire cohort into low-volume, middle-volume, and high-volume centers. After propensity score matching, 1,238 patients were analyzed-619 (50.0%) in the high-volume group, 523 (42.2%) in the middle-volume group, and 96 (7.8%) in the low-volume group. Patients who underwent surgery in higher-volume institutions had progressively better 5-year disease-free survival than those who underwent surgery in lower-volume centers (92.3% vs 88.9% vs 83.8%, P=.029). No difference was noted in 5-year overall survival (95.9% vs 97.2% vs 95.2%, P=.70). Cox multivariable regression analysis showed that FIGO stage greater than IB1, presence of lymphovascular space invasion, grade greater than 1, tumor diameter greater than 20 mm, minimally invasive surgical approach, nonsquamous cell carcinoma histology, and lower-volume centers represented independent risk factors for recurrence. CONCLUSION: Surgical volume of centers represented an independent prognostic factor affecting disease-free survival. Increasing number of radical hysterectomies performed in each center every year was associated with improved disease-free survival.
Gynecology Medical University of Graz Graz Austria
Memorial Sloan Kettering Cancer Center New York New York
the Department of Gynecologic Oncology Barretos Cancer Hospital Barretos Sao Paulo Brazil
the Department of Gynecologic Oncology Instituto Nacional de Cancerología Bogotá Colombia
the Department of Gynecological Surgery National Institute of Neoplastic Diseases Lima Peru
the Gynecologic Oncology Unit La Paz University Hospital IdiPAZ Madrid Spain
the Gynecology Oncology Center National Institute of Cancerology Mexico Mexico City Mexico
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23004695
- 003
- CZ-PrNML
- 005
- 20230425171651.0
- 007
- ta
- 008
- 230418s2023 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/AOG.0000000000005026 $2 doi
- 035 __
- $a (PubMed)36701621
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Bizzarri, Nicolò $u UOC Ginecologia Oncologica, Dipartimento per la Salute della Donna e del Bambino e della Salute Pubblica, and the Biostatistics Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, and the University of Milano-Bicocca, Department of Obstetrics and Gynecology, Gynaecologic Oncology Surgical Unit, ASST-Monza, San Gerardo Hospital, Monza, Italy; the Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital (Central and Eastern European Gynecologic Oncology Group, CEEGOG), and the Department of Gynaecology and Obstetrics, University Hospital Pilsen, Charles University, Prague, the Department of Obstetrics and Gynecology, Faculty of Medicine, University Hospital and University of Ostrava, Ostrava, and the University Hospital Brno, Medical Faculty of Masaryk University, Brno, Czech Republic; the Center for Gynaecologic Oncology Amsterdam, Amsterdam University Medical Centers, Amsterdam, the Netherlands; the Department of Gynecological Surgery, National Institute of Neoplastic Diseases, Lima, Peru; the Department of Pelvic Cancer, Karolinska University Hospital and Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; the Baskent University School of Medicine, Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, and the Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health and Research Hospital, University of Health Sciences, Ankara, Turkey; Memorial Sloan Kettering Cancer Center, New York, New York; the Gynecology Oncology Center, National Institute of Cancerology Mexico, Mexico City, Mexico; the Department of Gynecologic Oncology, Instituto Nacional de Cancerología, Bogotá, Colombia; the Wolfson Institute of Preventive Medicine, Barts Cancer Centre, Queen Mary University of London, & Barts Health NHS Trust, London, United Kingdom; the Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; the Department of Gynecologic Oncology, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano, Buenos Aires, Argentina; Gynecology, Medical University of Graz, Graz, Austria; the Gynecologic Oncology Unit, La Paz University Hospital - IdiPAZ, Madrid, Spain; and the Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil
- 245 10
- $a Association of Hospital Surgical Volume With Survival in Early-Stage Cervical Cancer Treated With Radical Hysterectomy / $c N. Bizzarri, L. Dostálek, LRCW. van Lonkhuijzen, D. Giannarelli, A. Lopez, H. Falconer, D. Querleu, A. Ayhan, SH. Kim, DI. Ortiz, J. Klat, F. Landoni, J. Rodriguez, R. Manchanda, J. Kosťun, PT. Ramirez, MM. Meydanli, D. Odetto, R. Laky, I. Zapardiel, V. Weinberger, R. Dos Reis, L. Pedone Anchora, K. Amaro, S. Salehi, H. Akilli, NR. Abu-Rustum, RA. Salcedo-Hernández, V. Javůrková, CH. Mom, G. Scambia, D. Cibula
- 520 9_
- $a OBJECTIVE: To evaluate the association of number of radical hysterectomies performed per year in each center with disease-free survival and overall survival. METHODS: We conducted an international, multicenter, retrospective study of patients previously included in the Surveillance in Cervical Cancer collaborative studies. Individuals with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IB1-IIA1 cervical cancer who underwent radical hysterectomy and had negative lymph nodes at final histology were included. Patients were treated at referral centers for gynecologic oncology according to updated national and international guidelines. Optimal cutoffs for surgical volume were identified using an unadjusted Cox proportional hazard model, with disease-free survival as the outcome and defined as the value that minimizes the P-value of the split in groups in terms of disease-free survival. Propensity score matching was used to create statistically similar cohorts at baseline. RESULTS: A total of 2,157 patients were initially included. The two most significant cutoffs for surgical volume were identified at seven and 17 surgical procedures, dividing the entire cohort into low-volume, middle-volume, and high-volume centers. After propensity score matching, 1,238 patients were analyzed-619 (50.0%) in the high-volume group, 523 (42.2%) in the middle-volume group, and 96 (7.8%) in the low-volume group. Patients who underwent surgery in higher-volume institutions had progressively better 5-year disease-free survival than those who underwent surgery in lower-volume centers (92.3% vs 88.9% vs 83.8%, P=.029). No difference was noted in 5-year overall survival (95.9% vs 97.2% vs 95.2%, P=.70). Cox multivariable regression analysis showed that FIGO stage greater than IB1, presence of lymphovascular space invasion, grade greater than 1, tumor diameter greater than 20 mm, minimally invasive surgical approach, nonsquamous cell carcinoma histology, and lower-volume centers represented independent risk factors for recurrence. CONCLUSION: Surgical volume of centers represented an independent prognostic factor affecting disease-free survival. Increasing number of radical hysterectomies performed in each center every year was associated with improved disease-free survival.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 12
- $a nádory děložního čípku $x patologie $7 D002583
- 650 _2
- $a staging nádorů $7 D009367
- 650 _2
- $a přežití bez známek nemoci $7 D018572
- 650 _2
- $a nemocnice $7 D006761
- 650 _2
- $a hysterektomie $x metody $7 D007044
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Dostálek, Lukáš
- 700 1_
- $a van Lonkhuijzen, Luc R C W
- 700 1_
- $a Giannarelli, Diana
- 700 1_
- $a Lopez, Aldo
- 700 1_
- $a Falconer, Henrik
- 700 1_
- $a Querleu, Denis
- 700 1_
- $a Ayhan, Ali
- 700 1_
- $a Kim, Sarah H
- 700 1_
- $a Ortiz, David Isla
- 700 1_
- $a Klat, Jaroslav
- 700 1_
- $a Landoni, Fabio
- 700 1_
- $a Rodriguez, Juliana
- 700 1_
- $a Manchanda, Ranjit
- 700 1_
- $a Kosťun, Jan
- 700 1_
- $a Ramirez, Pedro T
- 700 1_
- $a Meydanli, Mehmet M
- 700 1_
- $a Odetto, Diego
- 700 1_
- $a Laky, Rene
- 700 1_
- $a Zapardiel, Ignacio
- 700 1_
- $a Weinberger, Vit
- 700 1_
- $a Dos Reis, Ricardo
- 700 1_
- $a Pedone Anchora, Luigi
- 700 1_
- $a Amaro, Karina
- 700 1_
- $a Salehi, Sahar
- 700 1_
- $a Akilli, Huseyin
- 700 1_
- $a Abu-Rustum, Nadeem R
- 700 1_
- $a Salcedo-Hernández, Rosa A
- 700 1_
- $a Javůrková, Veronika
- 700 1_
- $a Mom, Constantijne H
- 700 1_
- $a Scambia, Giovanni
- 700 1_
- $a Cibula, David
- 773 0_
- $w MED00003576 $t Obstetrics and gynecology $x 1873-233X $g Roč. 141, č. 1 (2023), s. 207-214
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36701621 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230418 $b ABA008
- 991 __
- $a 20230425171647 $b ABA008
- 999 __
- $a ok $b bmc $g 1925028 $s 1190904
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 141 $c 1 $d 207-214 $e 20221130 $i 1873-233X $m Obstetrics and gynecology $n Obstet Gynecol $x MED00003576
- LZP __
- $a Pubmed-20230418
