-
Je něco špatně v tomto záznamu ?
Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods
D. Kadlcikova, P. Musilova, H. Hradska, M. Vozdova, M. Petrovova, M. Svoboda, J. Rubes
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- chromozomální aberace MeSH
- cytogenetické vyšetření MeSH
- hybridizace in situ fluorescenční MeSH
- lidé MeSH
- lymfocyty MeSH
- personál nemocniční MeSH
- pracovní expozice * škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The study assessed occupationally induced chromosomal damage in hospital personnel at risk of exposure to antineoplastic drugs and/or low doses of ionizing radiation by two cytogenetic methods. Cultured peripheral blood lymphocytes of eighty-five hospital workers were examined twice over 2 to 3 years by classical chromosomal aberration analysis and fluorescence in situ hybridization. The comparison of the 1st and the 2nd sampling of hospital workers showed a significant increase in chromatid and chromosomal aberrations (all p < .05) examined by classical chromosomal aberration analysis, and in unstable aberrations (all p < .05) detected by fluorescence in situ hybridization. Both cytogenetic methods were able to detect an increase of unstable aberrations in the 2nd sampling. The raised frequency of unstable cytogenetic parameters suggested higher recent exposure to genotoxic agents.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23004816
- 003
- CZ-PrNML
- 005
- 20240904102310.0
- 007
- ta
- 008
- 230418s2023 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/19338244.2022.2118213 $2 doi
- 035 __
- $a (PubMed)36073861
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Kadlcikova, Dita $u Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology - Veterinary Research Institute, Brno, Czech Republic $1 https://orcid.org/0000000255372130
- 245 10
- $a Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods / $c D. Kadlcikova, P. Musilova, H. Hradska, M. Vozdova, M. Petrovova, M. Svoboda, J. Rubes
- 520 9_
- $a The study assessed occupationally induced chromosomal damage in hospital personnel at risk of exposure to antineoplastic drugs and/or low doses of ionizing radiation by two cytogenetic methods. Cultured peripheral blood lymphocytes of eighty-five hospital workers were examined twice over 2 to 3 years by classical chromosomal aberration analysis and fluorescence in situ hybridization. The comparison of the 1st and the 2nd sampling of hospital workers showed a significant increase in chromatid and chromosomal aberrations (all p < .05) examined by classical chromosomal aberration analysis, and in unstable aberrations (all p < .05) detected by fluorescence in situ hybridization. Both cytogenetic methods were able to detect an increase of unstable aberrations in the 2nd sampling. The raised frequency of unstable cytogenetic parameters suggested higher recent exposure to genotoxic agents.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hybridizace in situ fluorescenční $7 D017404
- 650 12
- $a pracovní expozice $x škodlivé účinky $7 D016273
- 650 _2
- $a chromozomální aberace $7 D002869
- 650 _2
- $a personál nemocniční $7 D010564
- 650 _2
- $a cytogenetické vyšetření $7 D020732
- 650 _2
- $a lymfocyty $7 D008214
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Musilová, Petra $u Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology - Veterinary Research Institute, Brno, Czech Republic $1 https://orcid.org/0000000177931960 $7 xx0124180
- 700 1_
- $a Hradska, Hana $u Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology - Veterinary Research Institute, Brno, Czech Republic
- 700 1_
- $a Vozdova, Miluse $u Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology - Veterinary Research Institute, Brno, Czech Republic $1 https://orcid.org/0000000190768221 $7 xx0106434
- 700 1_
- $a Petrovova, Marketa $u Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic $1 https://orcid.org/000000016739388X
- 700 1_
- $a Svoboda, Marek $u Clinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic $1 https://orcid.org/0000000344550461
- 700 1_
- $a Rubes, Jiri $u Department of Genetics and Reproductive Biotechnologies, Central European Institute of Technology - Veterinary Research Institute, Brno, Czech Republic $1 https://orcid.org/0000000181266721
- 773 0_
- $w MED00152335 $t Archives of environmental & occupational health $x 2154-4700 $g Roč. 78, č. 3 (2023), s. 158-169
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36073861 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230418 $b ABA008
- 991 __
- $a 20240904102306 $b ABA008
- 999 __
- $a ok $b bmc $g 1925106 $s 1191025
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 78 $c 3 $d 158-169 $e 20220908 $i 2154-4700 $m Archives of environmental & occupational health $n Arch Environ Occup Health $x MED00152335
- LZP __
- $a Pubmed-20230418
