Heterocyclic compounds have been featured as the key building blocks for the development of biologically active molecules. In addition to being derived from renewable raw materials, fatty acids possess a variety of biological properties. The two bioactive ingredients are being combined by many researchers to produce hybrid molecules that have a number of desirable properties. Biological activities and significance of heterocyclic derivatives of fatty acids have been demonstrated in a new class of heterocyclic compounds called heterocyclic fatty acid hybrid derivatives. The significance of heterocyclic-fatty acid hybrid derivatives has been emphasized in numerous research articles over the past few years. In this review, we emphasize the development of synthetic methods and their biological evaluation for heterocyclic fatty acid derivatives. These reports, combined with the upcoming compilation, are expected to serve as comprehensive foundations and references for synthetic, preparative, and applicable methods in medicinal chemistry.

Chemistry of Natural Compounds Department Pharmaceutical and Drug Industries Research Institute National Research Centre Dokki Cairo Egypt

Department of Biomolecular Spectroscopy Institute of Organic Chemistry and Biochemistry Academy of Sciences Prague Czech Republic

Department of Green Chemistry National Research Center Dokki Cairo 12622 Egypt

Department of Pharmaceutical Chemistry Faculty of Pharmacy Ain Shams University Cairo P O Box 11566 Egypt

Department of Pharmaceutical Chemistry Faculty of Pharmacy Kafrelsheikh University Kafrelsheikh P O Box 33516 Egypt

Department of Pharmacognosy College of Pharmacy King Khalid University Asir 61421 Saudi Arabia

Medicinal and Pharmaceutical Chemistry Department Pharmaceutical and Drug Industries Research Division National Research Centre 33 El Bohouth St P O 12622 Dokki Giza Egypt

School of Biotechnology Badr University in Cairo Cairo 11829 Egypt

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