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Neonatal sepsis definitions from randomised clinical trials
R. Hayes, J. Hartnett, G. Semova, C. Murray, K. Murphy, L. Carroll, H. Plapp, L. Hession, J. O'Toole, D. McCollum, E. Roche, E. Jenkins, D. Mockler, T. Hurley, M. McGovern, J. Allen, J. Meehan, FB. Plötz, T. Strunk, WP. de Boode, R. Polin, JL....
Language English Country United States
Document type Meta-Analysis, Systematic Review, Research Support, Non-U.S. Gov't
Grant support
MR/N008405/1
Medical Research Council - United Kingdom
NLK
Free Medical Journals
from 1967 to 1 year ago
ProQuest Central
from 2016-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2016-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2016-01-01 to 1 year ago
- MeSH
- Child MeSH
- Adult MeSH
- Infant MeSH
- Infant Mortality MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Neonatal Sepsis * diagnosis MeSH
- Randomized Controlled Trials as Topic MeSH
- Sepsis diagnosis therapy MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Systematic Review MeSH
INTRODUCTION: Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current definitions of neonatal sepsis in published randomised controlled trials (RCTs). METHOD: A systematic search of the Embase and Cochrane databases was performed for RCTs which explicitly stated a definition for neonatal sepsis. Definitions were sub-divided into five primary criteria for infection (culture, laboratory findings, clinical signs, radiological evidence and risk factors) and stratified by qualifiers (early/late-onset and likelihood of sepsis). RESULTS: Of 668 papers screened, 80 RCTs were included and 128 individual definitions identified. The single most common definition was neonatal sepsis defined by blood culture alone (n = 35), followed by culture and clinical signs (n = 29), and then laboratory tests/clinical signs (n = 25). Blood culture featured in 83 definitions, laboratory testing featured in 48 definitions while clinical signs and radiology featured in 80 and 8 definitions, respectively. DISCUSSION: A diverse range of definitions of neonatal sepsis are used and based on microbiological culture, laboratory tests and clinical signs in contrast to adult and paediatric sepsis which use organ dysfunction. An international consensus-based definition of neonatal sepsis could allow meta-analysis and translate results to improve outcomes.
Department of Neonatology Pirogov Russian National Research Medical University Moscow Russia
Department of Paediatrics Tergooi Hospital Blaricum The Netherlands
Department of Pathology Immunology and Laboratory Medicine University of Florida Gainesville FL USA
Department of Pediatrics Bern University Hospital University of Bern Bern Switzerland
Department of Pediatrics University of Florida Gainesville FL USA
Division of Neonatology Saint Louis University Edward Doisy Research Center St Louis MO USA
John Stearne Medical Library Trinity College Dublin St James' Hospital Dublin Ireland
Neonatal Directorate King Edward Memorial Hospital for Women Perth WA Australia
Neonatal Health and Development Telethon Kids Institute Perth WA Australia
Neonatology CHI at Crumlin Dublin Ireland
Paediatric Intensive Care Unit Queensland Children's Hospital Brisbane Australia
Paediatrics Coombe Women's and Infant's University Hospital Dublin Ireland
Trinity Research in Childhood Centre Trinity College Dublin Dublin Ireland
Trinity Translational Medicine Institute St James Hospital Dublin Ireland
References provided by Crossref.org
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