Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

New challenges in cholangiocarcinoma candidates for elective surgery: harnessing the microbiome dysbiosis

OL. Re, V. López-López, A. Balaguer-Román, MA. Martínez-Sánchez, D. Eshmuminov, CJ. Llamoza-Torres, K. Miura, A. Baroja-Mazo, P. Ramírez, R. Robles-Campos, B. Ramos-Molina

. 2023 ; 408 (1) : 134. [pub] 20230331

Language English Country Germany

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc23010619

Grant support
FI21/00003 Instituto de Salud Carlos III
PI20/00505 Instituto de Salud Carlos III
CP19/00098, ISCIII, Spain Miguel Servet Type I

BACKGROUND: The gut microbiota, composed by several species of microorganisms, works to preserve the liver-gut homeostasis and plays an important role during digestion and absorption of nutrients, and in the immune response of the host. In this review, we analyzed the influence of microbiota in patients with cholangiocarcinoma (CCA) who were candidates for elective surgery. METHODS: A literature review was conducted to identify papers that provided empiric evidence to support that the altered microbiota composition (dysbiosis) is related also to CCA development. RESULTS: Bacteria such as Helicobacter pylori, Helicobacter hepaticus, and Opisthorchis viverrini increase the risk of CCA. The most abundant genera were Enterococcus, Streptococcus, Bacteroides, Klebsiella, and Pyramidobacter in CCA's biliary microbiota. Additionally, levels of Bacteroides, Geobacillus, Meiothermus, and Anoxybacillus genera were significantly higher. An enrichment of Bifidobacteriaceae, Enterobacteriaceae, and Enterococcaceae families has also been observed in CCA tumor tissue. Microbiota is related to postoperative outcomes in abdominal surgery. The combination of caloric restriction diets in liver cancer or CCA increases the effect of the chemotherapy treatment. CONCLUSION: The correct use of nutrition for microbiota modulation according to each patient's needs could be a therapeutic tool in combination with elective surgery and chemotherapy to diminish side effects and improve prognosis. Further investigations are needed to fully understand the mechanisms by which they are related.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23010619
003      
CZ-PrNML
005      
20230801132535.0
007      
ta
008      
230718s2023 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s00423-023-02867-8 $2 doi
035    __
$a (PubMed)37000331
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Re, Oriana Lo $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Department of Translational Stem Cell Biology, Research Institute of the Medical University of Varna, Varna, Bulgaria
245    10
$a New challenges in cholangiocarcinoma candidates for elective surgery: harnessing the microbiome dysbiosis / $c OL. Re, V. López-López, A. Balaguer-Román, MA. Martínez-Sánchez, D. Eshmuminov, CJ. Llamoza-Torres, K. Miura, A. Baroja-Mazo, P. Ramírez, R. Robles-Campos, B. Ramos-Molina
520    9_
$a BACKGROUND: The gut microbiota, composed by several species of microorganisms, works to preserve the liver-gut homeostasis and plays an important role during digestion and absorption of nutrients, and in the immune response of the host. In this review, we analyzed the influence of microbiota in patients with cholangiocarcinoma (CCA) who were candidates for elective surgery. METHODS: A literature review was conducted to identify papers that provided empiric evidence to support that the altered microbiota composition (dysbiosis) is related also to CCA development. RESULTS: Bacteria such as Helicobacter pylori, Helicobacter hepaticus, and Opisthorchis viverrini increase the risk of CCA. The most abundant genera were Enterococcus, Streptococcus, Bacteroides, Klebsiella, and Pyramidobacter in CCA's biliary microbiota. Additionally, levels of Bacteroides, Geobacillus, Meiothermus, and Anoxybacillus genera were significantly higher. An enrichment of Bifidobacteriaceae, Enterobacteriaceae, and Enterococcaceae families has also been observed in CCA tumor tissue. Microbiota is related to postoperative outcomes in abdominal surgery. The combination of caloric restriction diets in liver cancer or CCA increases the effect of the chemotherapy treatment. CONCLUSION: The correct use of nutrition for microbiota modulation according to each patient's needs could be a therapeutic tool in combination with elective surgery and chemotherapy to diminish side effects and improve prognosis. Further investigations are needed to fully understand the mechanisms by which they are related.
650    _2
$a lidé $7 D006801
650    12
$a opistorchióza $x mikrobiologie $7 D009889
650    _2
$a dysbióza $7 D064806
650    12
$a mikrobiota $7 D064307
650    12
$a cholangiokarcinom $x chirurgie $x patologie $7 D018281
650    _2
$a žlučové cesty intrahepatální $7 D001653
650    12
$a nádory žlučových cest $x chirurgie $7 D001650
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a López-López, Victor $u Department of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de La Arrixaca, IMIB-ARRIXACA, 30120, Murcia, Spain. victorrelopez@gmail.com $u Digestive and Endocrine Surgery and Transplantation of Abdominal Organs Research Group, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain. victorrelopez@gmail.com
700    1_
$a Balaguer-Román, Andrés $u Department of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de La Arrixaca, IMIB-ARRIXACA, 30120, Murcia, Spain $u Obesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
700    1_
$a Martínez-Sánchez, María Antonia $u Obesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
700    1_
$a Eshmuminov, Dilmurodjon $u Department of Surgery and Transplantation, Swiss Hepato-Pancreato-Biliary (HPB) Center, University Hospital Zurich, Zurich, Switzerland
700    1_
$a Llamoza-Torres, Camilo Julio $u Department of Hepatology, Virgen de La Arrixaca University Hospital, Murcia, Spain
700    1_
$a Miura, Kohei $u Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
700    1_
$a Baroja-Mazo, Alberto $u Digestive and Endocrine Surgery and Transplantation of Abdominal Organs Research Group, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
700    1_
$a Ramírez, Pablo $u Department of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de La Arrixaca, IMIB-ARRIXACA, 30120, Murcia, Spain $u Digestive and Endocrine Surgery and Transplantation of Abdominal Organs Research Group, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
700    1_
$a Robles-Campos, Ricardo $u Department of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de La Arrixaca, IMIB-ARRIXACA, 30120, Murcia, Spain $u Digestive and Endocrine Surgery and Transplantation of Abdominal Organs Research Group, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
700    1_
$a Ramos-Molina, Bruno $u Obesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain
773    0_
$w MED00005024 $t Langenbeck's archives of surgery $x 1435-2451 $g Roč. 408, č. 1 (2023), s. 134
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37000331 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230718 $b ABA008
991    __
$a 20230801132532 $b ABA008
999    __
$a ok $b bmc $g 1963201 $s 1196884
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 408 $c 1 $d 134 $e 20230331 $i 1435-2451 $m Langenbeck's archives of surgery $n Langenbecks Arch Surg $x MED00005024
GRA    __
$a FI21/00003 $p Instituto de Salud Carlos III
GRA    __
$a PI20/00505 $p Instituto de Salud Carlos III
GRA    __
$a CP19/00098, ISCIII, Spain $p Miguel Servet Type I
LZP    __
$a Pubmed-20230718

Find record

Citation metrics

Archiving options