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Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis

G. Turcu, C. Artenie, D. Nowicka, M. Arenbergerová, E. Lazaridou, K. Khobzei, A. Ataseven, M. Part, S. Leclerc-Mercier

. 2023 ; 33 (S1) : 19-23. [pub] 2023Mar01

Language English Country France

Document type Observational Study, Multicenter Study, Journal Article

Persistent link   https://www.medvik.cz/link/bmc23010658

UNLABELLED: Seborrheic Dermatitis (SD) is a chronic and relapsing inflammatory condition accompanied by erythema, flaking and itching. Dandruff is a milder form of SD. Selenium disulfide (SeS2) is beneficial in both conditions. OBJECTIVES: to assess the efficacy of SeS2-based shampoo in dandruff/SD. MATERIALS & METHODS: an international, multicenter, observational study was conducted in 1407 adult subjects. SeS2- based shampoo was used 2 to 3 times per week for 4 weeks. Clinical efficacy criteria included improvement of hair, flaking, erythema and irritation on a scale from 0 to 5; investigator satisfaction was assessed at month 3 from 0 to 10. The subjects rated the impact of their hair problem (0 to 5), efficacy and satisfaction with SeS2-based shampoo at month 3. Tolerance was assessed throughout the study. RESULTS: At baseline, 68.2% had a flake severity score of 3-5, 49.9% an erythema severity score of 3-5, and 46.2% an irritation severity score of 3-5; 28.2% were bothered and 41.5% were very bothered. At study end, SD/D had at least clearly improved in 89.6% of subjects. All clinical signs had significantly (p<0.001) improved. 95.6% of subjects reported less pruritus. Significantly fewer (15.4%, p<0.0001) subjects were still bothered. The overall subject satisfaction score was 8.9±1.4; 97.6% of investigators were satisfied or very satisfied. Tolerance was good or very good in 98.8% of subjects. CONCLUSION: A SeS2-based shampoo applied 2 to 3 times per week is efficient and well tolerated in dandruff and SD.

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$a UNLABELLED: Seborrheic Dermatitis (SD) is a chronic and relapsing inflammatory condition accompanied by erythema, flaking and itching. Dandruff is a milder form of SD. Selenium disulfide (SeS2) is beneficial in both conditions. OBJECTIVES: to assess the efficacy of SeS2-based shampoo in dandruff/SD. MATERIALS & METHODS: an international, multicenter, observational study was conducted in 1407 adult subjects. SeS2- based shampoo was used 2 to 3 times per week for 4 weeks. Clinical efficacy criteria included improvement of hair, flaking, erythema and irritation on a scale from 0 to 5; investigator satisfaction was assessed at month 3 from 0 to 10. The subjects rated the impact of their hair problem (0 to 5), efficacy and satisfaction with SeS2-based shampoo at month 3. Tolerance was assessed throughout the study. RESULTS: At baseline, 68.2% had a flake severity score of 3-5, 49.9% an erythema severity score of 3-5, and 46.2% an irritation severity score of 3-5; 28.2% were bothered and 41.5% were very bothered. At study end, SD/D had at least clearly improved in 89.6% of subjects. All clinical signs had significantly (p<0.001) improved. 95.6% of subjects reported less pruritus. Significantly fewer (15.4%, p<0.0001) subjects were still bothered. The overall subject satisfaction score was 8.9±1.4; 97.6% of investigators were satisfied or very satisfied. Tolerance was good or very good in 98.8% of subjects. CONCLUSION: A SeS2-based shampoo applied 2 to 3 times per week is efficient and well tolerated in dandruff and SD.
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$a Artenie, Claudia $u Carol Davila University of Medicine and Pharmacy, Derma 360 Clinic - Bucharest, Romania
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$a Nowicka, Danuta $u Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
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$a Arenbergerová, Monika $u Department of Dermato-Venereology, Third Faculty of Medicine, Charles University, Královské Vinohrady University Hospital, Prague, Czech Republic
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$a Lazaridou, Elisabet $u 2nd Department of Dermatology-Venereology, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece
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$a Khobzei, Kuzma $u Department of Dermatology, Kyiv Medical University, Khobzei Clinic, Kyiv, Ukraine
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$a Ataseven, Arzu $u Department of Dermatology, Faculty of Medicine, University Meram, Konya, Turkey
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$a Part, Martina $u Department of Dermatology and Venereology, Comenius University in Bratislava, Bratislava, Slovakia
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