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Serial Measurement of Interleukin-6 Enhances Chance to Exclude Early-Onset Sepsis in Very Preterm Infants
I. Berka, P. Korček, Z. Straňák
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biomarkers MeSH
- C-Reactive Protein analysis MeSH
- Interleukin-6 MeSH
- Humans MeSH
- Infant, Premature, Diseases * MeSH
- Infant, Premature MeSH
- Infant, Newborn MeSH
- Neonatal Sepsis * diagnosis MeSH
- Reproducibility of Results MeSH
- Retrospective Studies MeSH
- Sepsis * diagnosis MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The aim of this retrospective study was to evaluate the reliability of peak interleukin-6 (IL-6) level within 24 hours after delivery as a predictor for early-onset sepsis (EOS) in very preterm neonates. Interleukin-6 was assessed at 2 hours and at 12 to 24 hours after delivery. The highest level was considered a peak value. The definition of EOS was based on positive blood culture and clinical signs of infection or negative blood culture, clinical signs of infection, and C-reactive protein >10 mg/L. Among 445 enrolled infants, 53 developed EOS. A peak IL-6 level of more than 200 ng/L had a sensitivity of 89% and specificity of 77% for the presence of EOS. The negative predictive value was 98%. Receiver operating characteristics curve had area under the curve of 0.92. Peak IL-6 is a reliable marker of systemic inflammatory response and might be useful to exclude EOS within the first 24 hours.
3rd Faculty of Medicine Charles University Prague Czech Republic
Institute for the Care of Mother and Child Neonatology Prague Czech Republic
References provided by Crossref.org
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