With the current expansion of vector-based research and an increasing number of facilities rearing arthropod vectors and infecting them with pathogens, common measures for containment of arthropods as well as manipulation of pathogens are becoming essential for the design and running of such research facilities to ensure safe work and reproducibility, without compromising experimental feasibility. These guidelines and comments were written by experts of the Infravec2 consortium, a Horizon 2020-funded consortium integrating the most sophisticated European infrastructures for research on arthropod vectors of human and animal diseases. They reflect current good practice across European laboratories with experience of safely handling different mosquito species and the pathogens they transmit. As such, they provide experience-based advice to assess and manage the risks to work safely with mosquitoes and the pathogens they transmit. This document can also form the basis for research with other arthropods, for example, midges, ticks or sandflies, with some modification to reflect specific requirements.

Centro Agricoltura Ambiente G Nicoli Crevalcore Italy

Department of Life Sciences Imperial College London London UK

Department of Parasitology Faculty of Science Charles University Prague Czech Republic

Institut Pasteur Genetics and Genomics of Insect Vectors Paris France

Institut Pasteur Unit of Arboviruses and Insect Vectors Paris France

IRTA Centre de Recerca en Sanitat Animal Campus de la UAB Cerdanyola del Vallès Spain

MIVEGEC Univ Montpellier IRD CNRS Montpellier France

MRC University of Glasgow Centre for Virus Research Glasgow UK

The Pirbright Institute Woking Surrey UK

UZH Institute of Parasitology University of Zürich Zürich Switzerland

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