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Current animal models of extracorporeal cardiopulmonary resuscitation: A scoping review
S. Ijuin, K. Liu, D. Gill, S. Kyun Ro, J. Vukovic, S. Ishihara, J. Belohlavek, G. Li Bassi, JY. Suen, JF. Fraser
Status neindexováno Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 2020
PubMed Central
od 2020
Elsevier Open Access Journals
od 2020-03-01
ROAD: Directory of Open Access Scholarly Resources
od 2020
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
AIM: Animal models of Extracorporeal Cardiopulmonary Resuscitation (ECPR) focusing on neurological outcomes are required to further the development of this potentially life-saving technology. The aim of this review is to summarize current animal models of ECPR. METHODS: A comprehensive database search of PubMed, EMBASE, and Web of Science was undertaken. Full-text publications describing animal models of ECPR between January 1, 2000, and June 30, 2022, were identified and included in the review. Data describing the conduct of the animal models of ECPR, measured variables, and outcomes were extracted according to pre-defined definitions. RESULTS: The search strategy yielded 805 unique reports of which 37 studies were included in the final analysis. Most studies (95%) described using a pig model of ECPR with the remainder (5%) describing a rat model. The most common method for induction of cardiac arrest was a fatal ventricular arrhythmia through electrical stimulation (70%). 10 studies reported neurological assessment of animals using physical examination, serum biomarkers, or electrophysiological findings, however, only two studies described a multimodal assessment. No studies reported the use of brain imaging as part of the neurological assessment. Return of spontaneous circulation was the most reported primary outcome, and no studies described the neurological status of the animal as the primary outcome. CONCLUSION: Current animal models of ECPR do not describe clinically relevant neurological outcomes after cardiac arrest. Further work is needed to develop models that more accurately mimic clinical scenarios and can test innovations that can be translated to the application of ECPR in clinical medicine.
Adult Intensive Care Services The Prince Charles Hospital Brisbane Australia
Critical Care Research Group The Prince Charles Hospital Brisbane Australia
Department of Emergency and Critical Care Medicine Hyogo Emergency Medical Center Kobe Japan
Faculty of Medicine University of Queensland Brisbane Australia
Queensland University of Technology Brisbane Australia
School of Biomedical Sciences University of Queensland Brisbane Australia
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