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Outcome of Application of Cryopreserved Amniotic Membrane Grafts in the Treatment of Chronic Nonhealing Wounds of Different Origins in Polymorbid Patients: A Prospective Multicenter Study
A. Svobodova, V. Horvath, L. Balogh, M. Zemlickova, R. Fiala, J. Burkert, M. Brabec, P. Stadler, J. Lindner, J. Bednar, K. Jirsova
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
NV18-08-00106
Ministry of Health of the Czech Republic
LM2023033
Ministry of Education, Youth and Sports, Czech Republic
Medical Diagnostics and Basic Medical Sciences
Charles University, Prague, Cooperatio
RVO 67985807
Institute of Computer Science, Czech Republic
PubMed Central od 2015
Europe PubMed Central od 2015
ProQuest Central od 2014-03-01
Open Access Digital Library od 2014-01-01
ROAD: Directory of Open Access Scholarly Resources od 2014
Odkazy
PubMed
37627785
DOI
10.3390/bioengineering10080900
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
To compare the therapeutic efficacy of cryopreserved amniotic membrane (AM) grafts and standard of care (SOC) in treating nonhealing wounds (NHW) through a prospective multicenter clinical trial, 42 patients (76% polymorbid) with 54 nonhealing wounds of various etiologies (mainly venous) and an average baseline size of 20 cm2 were included. All patients were treated for at least 6 weeks in the center before they were involved in the study. In the SOC group, 29 patients (36 wounds) were treated. If the wound healed less than 20% of the baseline size after 6 weeks, the patient was transferred to the AM group (35 patients, 43 wounds). Weekly visits included an assessment of the patient's condition, photo documentation, wound debridement, and dressing. Quality of life and the pain degree were subjectively reported by patients. After SOC, 7 wounds were healed completely, 1 defect partially, and 28 defects remained unhealed. AM application led to the complete closure of 24 wounds, partial healing occurred in 10, and 9 remained unhealed. The degree of pain and the quality of life improved significantly in all patients after AM application. This study demonstrates the effectiveness of cryopreserved AM grafts in the healing of NHW of polymorbid patients and associated pain reduction.
Department of Cardiovascular Surgery Motol University Hospital 150 06 Prague Czech Republic
Department of Transplantation and Tissue Bank Motol University Hospital 150 06 Prague Czech Republic
Department of Vascular Surgery Na Homolce Hospital 150 30 Prague Czech Republic
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- $a To compare the therapeutic efficacy of cryopreserved amniotic membrane (AM) grafts and standard of care (SOC) in treating nonhealing wounds (NHW) through a prospective multicenter clinical trial, 42 patients (76% polymorbid) with 54 nonhealing wounds of various etiologies (mainly venous) and an average baseline size of 20 cm2 were included. All patients were treated for at least 6 weeks in the center before they were involved in the study. In the SOC group, 29 patients (36 wounds) were treated. If the wound healed less than 20% of the baseline size after 6 weeks, the patient was transferred to the AM group (35 patients, 43 wounds). Weekly visits included an assessment of the patient's condition, photo documentation, wound debridement, and dressing. Quality of life and the pain degree were subjectively reported by patients. After SOC, 7 wounds were healed completely, 1 defect partially, and 28 defects remained unhealed. AM application led to the complete closure of 24 wounds, partial healing occurred in 10, and 9 remained unhealed. The degree of pain and the quality of life improved significantly in all patients after AM application. This study demonstrates the effectiveness of cryopreserved AM grafts in the healing of NHW of polymorbid patients and associated pain reduction.
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