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Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease
AC. Müller-Nedebock, MCJ. Dekker, MJ. Farrer, N. Hattori, SY. Lim, GD. Mellick, I. Rektorová, M. Salama, AFS. Schuh, AJ. Stoessl, CM. Sue, AH. Tan, RL. Vidal, C. Klein, S. Bardien
Status neindexováno Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
Grantová podpora
Bartlett Fund for Critical Challenges
American University in Cairo (AUC)
FOR2488
Deutsche Forschungsgemeinschaft (German Research Foundation)
NLK
Directory of Open Access Journals
od 2015
Nature Open Access
od 2015-12-01
PubMed Central
od 2015
Europe PubMed Central
od 2015
ProQuest Central
od 2015-04-01
Open Access Digital Library
od 2015-04-22
Open Access Digital Library
od 2015-01-01
Health & Medicine (ProQuest)
od 2015-04-01
ROAD: Directory of Open Access Scholarly Resources
od 2015
Springer Nature OA/Free Journals
od 2015-12-01
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. The aim of this article was to explore some of these different theories by summarizing the viewpoints of laboratory and clinician scientists in the PD field, on the biological basis of the disease. To achieve this aim, we posed this question to thirteen "PD experts" from six continents (for global representation) and collated their personal opinions into this article. The views were varied, ranging from toxin exposure as a PD trigger, to LRRK2 as a potential root cause, to toxic alpha-synuclein being the most important etiological contributor. Notably, there was also growing recognition that the definition of PD as a single disease should be reconsidered, perhaps each with its own unique pathobiology and treatment regimen.
Applied Neuroscience Research Group CEITEC Masaryk University Brno Czech Republic
Centro de Biología Integrativa Facultad de Ciencias Universidad Mayor Santiago Chile
Centro FONDAP de Gerociencia Salud Mental y Metabolismo Santiago Chile
Departamento de Farmacologia Universidade Federal do Rio Grande do Sul Porto Alegre Brazil
Department of Internal Medicine Kilimanjaro Christian Medical Centre Moshi Tanzania
Faculty of Medicine Mansoura University Dakahleya Egypt
Faculty of Medicine University of New South Wales
Griffith Institute of Drug Discovery Griffith University Brisbane QLD Australia
Institute of Global Health and Human Ecology New Cairo 11835 Egypt
Instituto de Neurociencia Biomédica Facultad de Medicina Universidad de Chile Santiago Chile
Kinghorn Centre for Clinical Genomics Garvan Institute of Medical Research Darlinghurst
Neuroscience Research Australia
Serviço de Neurologia Hospital de Clínicas de Porto Alegre Porto Alegre Brazil
Citace poskytuje Crossref.org
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