-
Je něco špatně v tomto záznamu ?
Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
E. Prchalova, Z. Kohoutova, K. Knittelova, D. Malinak, K. Musilek
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy
Grantová podpora
GA22-14568S
Grantová Agentura České Republiky
CZ.02.2.69/0.0/0.0/19_073/0016949
Ministerstvo Školství, Mládeže a Tělovýchovy
Medline Complete (EBSCOhost) od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2002-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2002-01-01 do Před 1 rokem
Odkazy
PubMed
37642747
DOI
10.1007/s00204-023-03587-0
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa * MeSH
- biologická dostupnost MeSH
- biologický transport MeSH
- centrální nervový systém * MeSH
- hematoencefalická bariéra MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic organophosphate poisoning. They are effective nucleophiles that can restore the catalytic activity of acetylcholinesterase; however, their main limitation is the difficulty in crossing the blood-brain barrier (BBB) because of their strongly hydrophilic nature. Various approaches to overcome this limitation and enhance the bioavailability of oxime reactivators in the CNS have been evaluated; these include structural modifications, conjugation with molecules that have transporters in the BBB, bypassing the BBB through intranasal delivery, and inhibition of BBB efflux transporters. A promising approach is the use of nanoparticles (NPs) as the delivery systems. Studies using mesoporous silica nanomaterials, poly (L-lysine)-graft-poly(ethylene oxide) NPs, metallic organic frameworks, poly(lactic-co-glycolic acid) NPs, human serum albumin NPs, liposomes, solid lipid NPs, and cucurbiturils, have shown promising results. Some NPs are considered as nanoreactors for organophosphate detoxification; these combine bioscavengers with encapsulated oximes. This study provides an overview and critical discussion of the strategies used to enhance the bioavailability of oxime reactivators in the central nervous system.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23016058
- 003
- CZ-PrNML
- 005
- 20231026110519.0
- 007
- ta
- 008
- 231013s2023 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00204-023-03587-0 $2 doi
- 035 __
- $a (PubMed)37642747
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Prchalova, Eliska $u Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic $1 https://orcid.org/0000000302270007
- 245 10
- $a Strategies for enhanced bioavailability of oxime reactivators in the central nervous system / $c E. Prchalova, Z. Kohoutova, K. Knittelova, D. Malinak, K. Musilek
- 520 9_
- $a Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic organophosphate poisoning. They are effective nucleophiles that can restore the catalytic activity of acetylcholinesterase; however, their main limitation is the difficulty in crossing the blood-brain barrier (BBB) because of their strongly hydrophilic nature. Various approaches to overcome this limitation and enhance the bioavailability of oxime reactivators in the CNS have been evaluated; these include structural modifications, conjugation with molecules that have transporters in the BBB, bypassing the BBB through intranasal delivery, and inhibition of BBB efflux transporters. A promising approach is the use of nanoparticles (NPs) as the delivery systems. Studies using mesoporous silica nanomaterials, poly (L-lysine)-graft-poly(ethylene oxide) NPs, metallic organic frameworks, poly(lactic-co-glycolic acid) NPs, human serum albumin NPs, liposomes, solid lipid NPs, and cucurbiturils, have shown promising results. Some NPs are considered as nanoreactors for organophosphate detoxification; these combine bioscavengers with encapsulated oximes. This study provides an overview and critical discussion of the strategies used to enhance the bioavailability of oxime reactivators in the central nervous system.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a biologická dostupnost $7 D001682
- 650 12
- $a acetylcholinesterasa $7 D000110
- 650 12
- $a centrální nervový systém $7 D002490
- 650 _2
- $a hematoencefalická bariéra $7 D001812
- 650 _2
- $a biologický transport $7 D001692
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Kohoutova, Zuzana $u Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic $1 https://orcid.org/0000000333823997
- 700 1_
- $a Knittelova, Karolina $u Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic $1 https://orcid.org/0000000251878986
- 700 1_
- $a Malinak, David $u Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic. david.malinak@uhk.cz $u Biomedical Research Centre, University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. david.malinak@uhk.cz $1 https://orcid.org/0000000206650667
- 700 1_
- $a Musilek, Kamil $u Faculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic. kamil.musilek@uhk.cz $u Biomedical Research Centre, University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. kamil.musilek@uhk.cz $1 https://orcid.org/0000000275044062 $7 xx0135628
- 773 0_
- $w MED00009265 $t Archives of toxicology $x 1432-0738 $g Roč. 97, č. 11 (2023), s. 2839-2860
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/37642747 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20231013 $b ABA008
- 991 __
- $a 20231026110513 $b ABA008
- 999 __
- $a ok $b bmc $g 1999907 $s 1202420
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 97 $c 11 $d 2839-2860 $e 20230829 $i 1432-0738 $m Archives of toxicology $n Arch Toxicol $x MED00009265
- GRA __
- $a GA22-14568S $p Grantová Agentura České Republiky
- GRA __
- $a CZ.02.2.69/0.0/0.0/19_073/0016949 $p Ministerstvo Školství, Mládeže a Tělovýchovy
- LZP __
- $a Pubmed-20231013