Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Temporal variation in oral microbiome composition of patients undergoing autologous hematopoietic cell transplantation with keratinocyte growth factor

B. Bohn, M. Chalupova, C. Staley, S. Holtan, J. Maakaron, V. Bachanova, N. El Jurdi

. 2023 ; 23 (1) : 258. [pub] 20230913

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23016238

INTRODUCTION: Autologous hematopoietic cell transplantation (AHCT) is a well-established treatment for lymphoma. Unintended effects of this therapy include oral mucositis (OM) and gastrointestinal toxicities, resulting in poor clinical outcomes. The gut microbiome has been previously linked to transplant toxicities among allogeneic recipients, but little is known about the effects of AHCT on the oral microbiome. METHODS: Seven patients with non-Hodgkin or Hodgkin lymphoma undergoing AHCT with palifermin (keratinocyte growth factor) were included. Buccal swab samples were collected at baseline and 14- and 28-days post-treatment. Oral microbial communities were characterized with 16 S rRNA amplicon sequencing. Temporal trends in community composition, alpha diversity, and beta diversity were investigated. RESULTS: A significant reduction in the relative abundance of the genera Gemella and Actinomyces were observed from baseline. No significant temporal differences in alpha diversity were observed. Significant changes in beta diversity were recorded. CONCLUSION: Results of this pilot study suggest treatment with AHCT and palifermin affects the oral microbiome, resulting in temporal shifts in oral microbial community composition. Future studies are warranted to confirm these trends and further investigate the effects of AHCT on the oral microbiome and how these shifts may affect health outcomes.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23016238
003      
CZ-PrNML
005      
20231026110117.0
007      
ta
008      
231013s2023 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12866-023-03000-x $2 doi
035    __
$a (PubMed)37704974
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Bohn, Bruno $u Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Minneapolis, MN, 55455, USA. ferre083@umn.edu
245    10
$a Temporal variation in oral microbiome composition of patients undergoing autologous hematopoietic cell transplantation with keratinocyte growth factor / $c B. Bohn, M. Chalupova, C. Staley, S. Holtan, J. Maakaron, V. Bachanova, N. El Jurdi
520    9_
$a INTRODUCTION: Autologous hematopoietic cell transplantation (AHCT) is a well-established treatment for lymphoma. Unintended effects of this therapy include oral mucositis (OM) and gastrointestinal toxicities, resulting in poor clinical outcomes. The gut microbiome has been previously linked to transplant toxicities among allogeneic recipients, but little is known about the effects of AHCT on the oral microbiome. METHODS: Seven patients with non-Hodgkin or Hodgkin lymphoma undergoing AHCT with palifermin (keratinocyte growth factor) were included. Buccal swab samples were collected at baseline and 14- and 28-days post-treatment. Oral microbial communities were characterized with 16 S rRNA amplicon sequencing. Temporal trends in community composition, alpha diversity, and beta diversity were investigated. RESULTS: A significant reduction in the relative abundance of the genera Gemella and Actinomyces were observed from baseline. No significant temporal differences in alpha diversity were observed. Significant changes in beta diversity were recorded. CONCLUSION: Results of this pilot study suggest treatment with AHCT and palifermin affects the oral microbiome, resulting in temporal shifts in oral microbial community composition. Future studies are warranted to confirm these trends and further investigate the effects of AHCT on the oral microbiome and how these shifts may affect health outcomes.
650    _2
$a lidé $7 D006801
650    _2
$a fibroblastový růstový faktor 7 $7 D051523
650    _2
$a pilotní projekty $7 D010865
650    12
$a transplantace hematopoetických kmenových buněk $x škodlivé účinky $7 D018380
650    12
$a mikrobiota $7 D064307
650    12
$a střevní mikroflóra $7 D000069196
655    _2
$a časopisecké články $7 D016428
700    1_
$a Chalupova, Miroslava $u Department of Stomatology, Faculty of Medicine and University Hospital in Pilsen, Charles University, Plzen, Czech Republic
700    1_
$a Staley, Christopher $u Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN, USA
700    1_
$a Holtan, Shernan $u Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA
700    1_
$a Maakaron, Joseph $u Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA
700    1_
$a Bachanova, Veronika $u Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA
700    1_
$a El Jurdi, Najla $u Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA. neljurdi@umn.edu
773    0_
$w MED00008191 $t BMC microbiology $x 1471-2180 $g Roč. 23, č. 1 (2023), s. 258
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37704974 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20231013 $b ABA008
991    __
$a 20231026110110 $b ABA008
999    __
$a ok $b bmc $g 2000015 $s 1202600
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 23 $c 1 $d 258 $e 20230913 $i 1471-2180 $m BMC microbiology $n BMC Microbiol $x MED00008191
LZP    __
$a Pubmed-20231013

Najít záznam

Citační ukazatele

Možnosti archivace