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Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Y. Le Guen, G. Luo, A. Ambati, V. Damotte, I. Jansen, E. Yu, A. Nicolas, I. de Rojas, T. Peixoto Leal, A. Miyashita, C. Bellenguez, MM. Lian, K. Parveen, T. Morizono, H. Park, B. Grenier-Boley, T. Naito, F. Küçükali, SD. Talyansky, SM. Yogeshwar,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
R01 AG060747
NIA NIH HHS - United States
P30 AG066515
NIA NIH HHS - United States
R01 AG066206
NIA NIH HHS - United States
NLK
Free Medical Journals
od 1915 do Před 6 měsíci
Freely Accessible Science Journals
od 1915 do Před 6 měsíci
PubMed Central
od 1915 do Před 6 měsíci
Europe PubMed Central
od 1915 do Před 6 měsíci
Open Access Digital Library
od 1915-01-15
Open Access Digital Library
od 1915-01-01
PubMed
37643212
DOI
10.1073/pnas.2302720120
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc * genetika MeSH
- histokompatibilní antigeny MeSH
- HLA antigeny MeSH
- HLA-DRB1 řetězec * genetika MeSH
- lidé MeSH
- Parkinsonova nemoc * genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues.
Alzheimer Research Center and Memory Clinic Andalusian Institute for Neuroscience Málaga 29012 Spain
Alzheimer's Centre Reina Sofia CIEN Foundation Madrid Spain
Center for Infectious Disease Education and Research Osaka University Suita 565 0871 Japan
Center for Sleep Sciences and Medicine Stanford University Palo Alto 94304 CA
Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid Madrid 28049 Spain
Charité Universitätsmedizin Berlin Einstein Center for Neurosciences Berlin Berlin 10117 Germany
CHU de Bordeaux Pole santé publique Bordeaux 33400 France
Clinic of Neurology UH Alexandrovska Medical University Sofia Sofia 1431 Bulgaria
Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal SE 43180 Sweden
Department of Biomedical Science Chosun University Gwangju 61452 Korea
Department of Biomedical Science Chosun University Gwangju 61452 Republic of Korea
Department of Biomedical Sciences University of Antwerp Antwerp 2000 Belgium
Department of Biomedical Sciences University of Cagliari Cagliari 09124 Italy
Department of Biomedical Surgical and Dental Sciences University of Milan Milan 20122 Italy
Department of Clinical Genetics VU University Medical Centre Amsterdam 1081 HV The Netherlands
Department of Clinical Genomics Mayo Clinic Florida Jacksonville 32224 FL
Department of Clinical Medicine University of Copenhagen Copenhagen 1172 Denmark
Department of Clinical Sciences and Community Health University of Milan Milan 20122 Italy
Department of Epidemiology ErasmusMC Rotterdam 3000 CA The Netherlands
Department of Geriatric Psychiatry University Hospital of Psychiatry Zürich Zürich 8032 Switzerland
Department of Human Genetics McGill University Montreal Quebec H3A 0G4 Canada
Department of Integrative Biological Sciences Chosun University Gwangju 61452 Republic of Korea
Department of Molecular Genetics Brain Research Institute Niigata University Niigata 950 218 Japan
Department of Neurodegenerative Disease UCL Institute of Neurology London WC1E 6BT United Kingdom
Department of Neurology and Neurological Sciences Stanford University Stanford 94305 CA
Department of Neurology and Neurosurgery McGill University Montreal Quebec H3A 0G4 Canada
Department of Neurology Bordeaux University Hospital Bordeaux 33400 France
Department of Neurology Charité Universitätsmedizin Berlin 10117 Germany
Department of Neurology ErasmusMC Rotterdam 3000 CA Netherlands
Department of Neurology Graduate School of Medicine The University of Tokyo Tokyo 192 0982 Japan
Department of Neurology Hospital Universitario Donostia San Sebastian 20014 Spain
Department of Neuroscience Mayo Clinic Florida Jacksonville 32224 FL
Department of Neuroscience Rita Levi Montalcini University of Torino Torino 10126 Italy
Department of Neuroscience Università Cattolica del Sacro Cuore Rome 00168 Italy
Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston 77030 TX
Department of Psychiatry Old Age Psychiatry Lausanne University Hospital Lausanne 1005 Switzerland
Department of Public Health and Caring Sciences Uppsala University Uppsala 751 22 Sweden
Department of Statistical Genetics Osaka University Graduate School of Medicine Suita 565 0871 Japan
Duke National University of Singapore Medical School Singapore 169857 Singapore
Faculty of Medicine University of Lisbon Lisbon 1649 028 Portugal
Fondazione IRCCS Istituto Neurologico Carlo Besta Milan 20133 Italy
Fundació Docència i Recerca MútuaTerrassa Terrassa Barcelona 08221 Spain
Genomic Medicine Lerner Research Institute Cleveland Clinic Cleveland 44196 OH
Geriatrics Uppsala University Uppsala 751 22 Sweden
German Center for Neurodegenerative Diseases 37075 Göttingen Germany
German Center for Neurodegenerative Diseases Berlin 37075 Germany
German Center for Neurodegenerative Diseases Goettingen 37075 Germany
German Center for Neurodegenerative Diseases Magdeburg 39120 Germany
German Center for Neurodegenerative Diseases Munich 37075 Germany
Hong Kong Center for Neurodegenerative Diseases Hong Kong China
Hospital Universitario Ramon y Cajal IRYCIS Madrid 28034 Spain
Institut de Recerca Biomedica de Lleida Lleida 25198 Spain
Institut du Cerveau Paris Brain Institute ICM Paris 75013 France
Institute for Regenerative Medicine University of Zürich Zürich 8952 Switzerland
Institute of Biomedicine University of Eastern Finland Joensuu Kuopio Eastern Finland 80101 Finland
Institute of Clinical Medicine University of Oslo Oslo Norway
Institute of Neurology Catholic University of the Sacred Heart Rome 20123 Italy
Instituto de Investigación Sanitaria del Principado de Asturias Oviedo 33011 Spain
Instituto de Investigacion Sanitaria Hospital la Paz Madrid 48903 Spain
International Clinical Research Center St Anne's University Hospital Brno Brno 656 91 Czech Republic
IRCCS Fondazione Don Carlo Gnocchi Florence 20162 Italy
Korea Brain Research Institute Daegu 41062 Republic of Korea
Krembil Brain Institute University Health Network Toronto M5G 2C4 Canada
Laboratorio de Genética Hospital Universitario Central de Asturias Oviedo 33011 Spain
Laboratory of Neurogenetics Genome Institute of Singapore A*STAR Singapore 138672 Singapore
Laboratory of Neurogenetics Institute Born Bunge Antwerp 2610 Belgium
Laboratory of Neuropsychiatry IRCCS Santa Lucia Foundation Rome 00179 Italy
Munich Cluster for Systems Neurology Munich 81377 Germany
Neurodegenerative Diseases Unit Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan 20122 Italy
Neurology San Gerardo hospital Monza and University of Milano Bicocca Monza 20900 Italy
Neurology Service Marqués de Valdecilla University Hospital Santander 39011 Spain
Neurology Unit IRCCS Fondazione Policlinico Universitario A Gemelli Rome 00168 Italy
Neuroscience Center Zurich University of Zurich and ETH Zurich Zurich 8057 Switzerland
Neurosciences Area Instituto Biodonostia San Sebastian 20014 Spain
Neurozen Inc Seoul 06236 Republic of Korea
NORMENT Centre Division of Mental Health and Addiction Oslo University Hospital Oslo 0450 Norway
Nuffield Department of Population Health Oxford University Oxford OX3 7LF United Kingdom
Region Västra Götaland Sahlgrenska University Hospital Psychosis Clinic Gothenburg 413 45 Sweden
RIKEN Center for Integrative Medical Sciences Yokohama Japan
School of Medicine Cardiff University Wales CF14 4YS United Kingdom
The Neuro Montreal Quebec H3A 2B4 Canada
UK Dementia Research Institute at UCL London WC1E 6BT United Kingdom
Unidad Mixta de Neurologia Genètica Instituto de Investigación Sanitaria La Fe Valencia 46026 Spain
Unit of Neurology University of Parma and AOU Parma 43121 Italy
Unitat Trastorns Cognitius Hospital Universitari Santa Maria de Lleida Lleida 25198 Spain
Université de Paris EA 4468 APHP Hôpital Broca Paris 75013 France
Université Paris Saclay CEA Centre National de Recherche en Génomique Humaine Evry 91057 France
University Bordeaux Inserm Bordeaux Population Health Research Center Bordeaux 33000 France
Zurich Center for Integrative Human Physiology University of Zurich Zurich 8057 Switzerland
Citace poskytuje Crossref.org
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- $a Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes / $c Y. Le Guen, G. Luo, A. Ambati, V. Damotte, I. Jansen, E. Yu, A. Nicolas, I. de Rojas, T. Peixoto Leal, A. Miyashita, C. Bellenguez, MM. Lian, K. Parveen, T. Morizono, H. Park, B. Grenier-Boley, T. Naito, F. Küçükali, SD. Talyansky, SM. Yogeshwar, V. Sempere, W. Satake, V. Alvarez, B. Arosio, ME. Belloy, L. Benussi, A. Boland, B. Borroni, MJ. Bullido, P. Caffarra, J. Clarimon, A. Daniele, D. Darling, S. Debette, JF. Deleuze, M. Dichgans, C. Dufouil, E. During, E. Düzel, D. Galimberti, G. Garcia-Ribas, JM. García-Alberca, P. García-González, V. Giedraitis, O. Goldhardt, C. Graff, E. Grünblatt, O. Hanon, L. Hausner, S. Heilmann-Heimbach, H. Holstege, J. Hort, YJ. Jung, D. Jürgen, S. Kern, T. Kuulasmaa, KH. Lee, L. Lin, C. Masullo, P. Mecocci, S. Mehrabian, A. de Mendonça, M. Boada, P. Mir, S. Moebus, F. Moreno, B. Nacmias, G. Nicolas, S. Niida, BG. Nordestgaard, G. Papenberg, J. Papma, L. Parnetti, F. Pasquier, P. Pastor, O. Peters, YAL. Pijnenburg, G. Piñol-Ripoll, J. Popp, LM. Porcel, R. Puerta, J. Pérez-Tur, I. Rainero, I. Ramakers, LM. Real, S. Riedel-Heller, E. Rodriguez-Rodriguez, OA. Ross, J. Luís Royo, D. Rujescu, N. Scarmeas, P. Scheltens, N. Scherbaum, A. Schneider, D. Seripa, I. Skoog, V. Solfrizzi, G. Spalletta, A. Squassina, J. van Swieten, R. Sánchez-Valle, EK. Tan, T. Tegos, C. Teunissen, JQ. Thomassen, L. Tremolizzo, M. Vyhnalek, F. Verhey, M. Waern, J. Wiltfang, J. Zhang, EADB, GR@ACE study group, DEGESCO consortium, DemGene, EADI, GERAD, Asian Parkinson’s Disease Genetics consortium, H. Zetterberg, K. Blennow, Z. He, J. Williams, P. Amouyel, F. Jessen, PG. Kehoe, OA. Andreassen, C. Van Duin, M. Tsolaki, P. Sánchez-Juan, R. Frikke-Schmidt, K. Sleegers, T. Toda, A. Zettergren, M. Ingelsson, Y. Okada, G. Rossi, M. Hiltunen, J. Gim, K. Ozaki, R. Sims, JN. Foo, W. van der Flier, T. Ikeuchi, A. Ramirez, I. Mata, A. Ruiz, Z. Gan-Or, JC. Lambert, MD. Greicius, E. Mignot
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- $a Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues.
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- 700 1_
- $a Moebus, Susanne $u Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen 45147, Germany
- 700 1_
- $a Moreno, Fermin $u Networking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain $u Department of Neurology, Hospital Universitario Donostia, San Sebastian 20014, Spain $u Neurosciences Area, Instituto Biodonostia, San Sebastian 20014, Spain
- 700 1_
- $a Nacmias, Benedetta $u Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence 50121, Italy $u IRCCS Fondazione Don Carlo Gnocchi, Florence 20162, Italy
- 700 1_
- $a Nicolas, Gael $u Department of Genetics and CNR-MAJ, Normandie Univ, UNIROUEN, Inserm U1245 and CHU Rouen, Rouen F-76000, France
- 700 1_
- $a Niida, Shumpei $u Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan $1 https://orcid.org/0000000261928035
- 700 1_
- $a Nordestgaard, Børge G $u Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev Gentofte, Copenhagen 2730, Denmark $u Department of Clinical Medicine, University of Copenhagen, Copenhagen 1172, Denmark
- 700 1_
- $a Papenberg, Goran $u Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm 171 77, Sweden
- 700 1_
- $a Papma, Janne $u Department of Neurology, Alzheimer Center Erasmus MC, Erasmus University Medical Center, Rotterdam 3000, The Netherlands
- 700 1_
- $a Parnetti, Lucilla $u Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia 06123, Italy
- 700 1_
- $a Pasquier, Florence $u Université de Lille, Inserm 1172, CHU Clinical and Research Memory Research Centre of Distalz, Lille 59000, France $1 https://orcid.org/0000000198809788
- 700 1_
- $a Pastor, Pau $u Fundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona 08221, Spain $u Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona 08221, Spain
- 700 1_
- $a Peters, Oliver $u German Center for Neurodegenerative Diseases (DZNE), Berlin 37075, Germany $u Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin 12203, Germany
- 700 1_
- $a Pijnenburg, Yolande A L $u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands
- 700 1_
- $a Piñol-Ripoll, Gerard $u Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida 25198, Spain $u Institut de Recerca Biomedica de Lleida, Lleida 25198, Spain
- 700 1_
- $a Popp, Julius $u Department of Psychiatry, Old Age Psychiatry, Lausanne University Hospital, Lausanne 1005, Switzerland $u Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich 8032, Switzerland $u Institute for Regenerative Medicine, University of Zürich, Zürich 8952, Switzerland
- 700 1_
- $a Porcel, Laura Molina $u Neurological Tissue Bank-Biobanc- Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona 08036, Spain $u Alzheimer's disease and other cognitive disorders Unit, Neurology Department, Hospital Clinic, Barcelona 08036, Spain
- 700 1_
- $a Puerta, Raquel $u Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain
- 700 1_
- $a Pérez-Tur, Jordi $u Networking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain $u Unitat de Genètica Molecular, Institut de Biomedicina de València-Consejo Superior de Investigaciones Científicas Valencia 46010, Spain $u Unidad Mixta de Neurologia Genètica, Instituto de Investigación Sanitaria La Fe, Valencia 46026, Spain
- 700 1_
- $a Rainero, Innocenzo $u Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino 10126, Italy
- 700 1_
- $a Ramakers, Inez $u Department of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht University, Maastricht 6229 GS, The Netherlands
- 700 1_
- $a Real, Luis M $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla 41014, Spain $u Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga 29010, Spain $1 https://orcid.org/0000000349327429
- 700 1_
- $a Riedel-Heller, Steffi $u Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig 04109, Germany
- 700 1_
- $a Rodriguez-Rodriguez, Eloy $u Networking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain $u Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander 39011, Spain
- 700 1_
- $a Ross, Owen A $u Department of Neuroscience, Mayo Clinic-Florida, Jacksonville 32224, FL $u Department of Clinical Genomics, Mayo Clinic-Florida, Jacksonville 32224, FL
- 700 1_
- $a Luís Royo, Jose $u Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina, Universidad de Málaga, Málaga 29010, Spain
- 700 1_
- $a Rujescu, Dan $u Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale) 06120, Germany $1 https://orcid.org/000000021432313X
- 700 1_
- $a Scarmeas, Nikolaos $u Department of Neurology, The Gertrude H. Sergievsky Center, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York 10032, NY $u 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens 106 79, Greece
- 700 1_
- $a Scheltens, Philip $u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands
- 700 1_
- $a Scherbaum, Norbert $u Department of Psychiatry and Psychotherapy, Medical Faculty, LVR-Hospital Essen, University of Duisburg-Essen, 45147 Duisberg, Germany
- 700 1_
- $a Schneider, Anja $u German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), 37075 Göttingen, Germany $u Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn 53127, Germany
- 700 1_
- $a Seripa, Davide $u Department of Hematology and Stem Cell Transplant, Laboratory for Advanced Hematological Diagnostics, Lecce 73100, Italy
- 700 1_
- $a Skoog, Ingmar $u Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 405 30, Sweden $u Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 405 30, Sweden
- 700 1_
- $a Solfrizzi, Vincenzo $u Interdisciry Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari "A. Moro, Bari 70121, Italy
- 700 1_
- $a Spalletta, Gianfranco $u Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome 00179, Italy $u Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston 77030, TX $1 https://orcid.org/0000000274324249
- 700 1_
- $a Squassina, Alessio $u Department of Biomedical Sciences, University of Cagliari, Cagliari 09124, Italy
- 700 1_
- $a van Swieten, John $u Department of Neurology, ErasmusMC, Rotterdam 3000 CA, Netherlands
- 700 1_
- $a Sánchez-Valle, Raquel $u Alzheimer's disease and other cognitive disorders unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona 08036, Spain
- 700 1_
- $a Tan, Eng-King $u Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore 308433, Singapore $u Duke-National University of Singapore Medical School, Singapore 169857, Singapore
- 700 1_
- $a Tegos, Thomas $u 1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece
- 700 1_
- $a Teunissen, Charlotte $u Neurochemistry Lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, Netherlands
- 700 1_
- $a Thomassen, Jesper Qvist $u Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen 2100, Denmark
- 700 1_
- $a Tremolizzo, Lucio $u Neurology, "San Gerardo" hospital, Monza and University of Milano-Bicocca, Monza 20900, Italy
- 700 1_
- $a Vyhnalek, Martin $u Department of Clinical Genetics, VU University Medical Centre, Amsterdam 1081 HV, The Netherlands $u Department of Neurology, Memory Clinic, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague 150 06, Czech Republic
- 700 1_
- $a Verhey, Frans $u Department of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht University, Maastricht 6229 GS, Netherlands
- 700 1_
- $a Waern, Margda $u Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 431 41, Sweden $u Region Västra Götaland, Sahlgrenska University Hospital, Psychosis Clinic, Gothenburg 413 45, Sweden
- 700 1_
- $a Wiltfang, Jens $u Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen 37075, Germany $u German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), Goettingen 37075, Germany $u Department of Medical Sciences, Neurosciences and Signaling Group, Institute of Biomedicine, University of Aveiro, Aveiro 3810-193, Portugal
- 700 1_
- $a Zhang, Jing $u Center for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA
- 700 1_
- $a Zetterberg, Henrik $u Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal 431 41, Sweden $u Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal SE-43180, Sweden $u Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1E 6BT, United Kingdom $u UK Dementia Research Institute at UCL, London WC1E 6BT, United Kingdom $u Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China $1 https://orcid.org/0000000339304354
- 700 1_
- $a Blennow, Kaj $u Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal 431 41, Sweden $u Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal SE-43180, Sweden
- 700 1_
- $a He, Zihuai $u Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA
- 700 1_
- $a Williams, Julie $u UKDRI@Cardiff, School of Medicine, Cardiff University, Wales CF14 4YS, United Kingdom $u Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff Wales CF14 4XN, United Kingdom
- 700 1_
- $a Amouyel, Philippe $u Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France
- 700 1_
- $a Jessen, Frank $u German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), 37075 Göttingen, Germany $u Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany $u Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Cologne 50931, Germany
- 700 1_
- $a Kehoe, Patrick G $u Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1QU, United Kingdom
- 700 1_
- $a Andreassen, Ole A $u NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0450, Norway $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway $1 https://orcid.org/0000000244613568
- 700 1_
- $a Van Duin, Cornelia $u Department of Epidemiology, ErasmusMC, Rotterdam 3000 CA, The Netherlands $u Nuffield Department of Population Health Oxford University, Oxford OX3 7LF, United Kingdom
- 700 1_
- $a Tsolaki, Magda $u 1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece $1 https://orcid.org/0000000220728010
- 700 1_
- $a Sánchez-Juan, Pascual $u Networking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain $u Alzheimer's Centre Reina Sofia-CIEN Foundation, Madrid, Spain
- 700 1_
- $a Frikke-Schmidt, Ruth $u Department of Clinical Medicine, University of Copenhagen, Copenhagen 1172, Denmark $u Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen 2100, Denmark
- 700 1_
- $a Sleegers, Kristel $u Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp 2610, Belgium $u Laboratory of Neurogenetics, Institute Born-Bunge, Antwerp 2610, Belgium $u Department of Biomedical Sciences, University of Antwerp, Antwerp 2000, Belgium
- 700 1_
- $a Toda, Tatsushi $u Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 192-0982, Japan
- 700 1_
- $a Zettergren, Anna $u Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg 431 41, Sweden
- 700 1_
- $a Ingelsson, Martin $u Department of Public Health and Caring Sciences, Uppsala University, Uppsala 751 22, Sweden $u Geriatrics, Uppsala University, Uppsala 751 22, Sweden $u Krembil Brain Institute, University Health Network, Toronto M5G 2C4, Canada $u Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto M5S 1A8, Canada
- 700 1_
- $a Okada, Yukinori $u Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan $u Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan $u Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita 565-0871, Japan $u Center for Infectious Disease Education and Research, Osaka University, Suita 565-0871, Japan
- 700 1_
- $a Rossi, Giacomina $u Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy
- 700 1_
- $a Hiltunen, Mikko $u Institute of Biomedicine, University of Eastern Finland, Joensuu, Kuopio, Eastern Finland 80101, Finland
- 700 1_
- $a Gim, Jungsoo $u Department of Biomedical Science, Chosun University, Gwangju 61452, Korea $u Department of Integrative Biological Sciences, Chosun University, Gwangju 61452, Republic of Korea $u Gwangju Alzheimer's and Related Dementias Cohort Research Center, Chosun University, Gwangju 61452, Republic of Korea
- 700 1_
- $a Ozaki, Kouichi $u Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan $u RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
- 700 1_
- $a Sims, Rebecca $u Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales CF14 4YS, United Kingdom
- 700 1_
- $a Foo, Jia Nee $u Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore 308232, Singapore $u Laboratory of Neurogenetics, Genome Institute of Singapore, A*STAR, Singapore 138672, Singapore $1 https://orcid.org/0000000198992308
- 700 1_
- $a van der Flier, Wiesje $u Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands
- 700 1_
- $a Ikeuchi, Takeshi $u Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 950-218, Japan
- 700 1_
- $a Ramirez, Alfredo $u Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany $u Department of Neurodegenerative diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn 53127, Germany $u German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen), 37075 Göttingen, Germany $u Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Cologne 50931, Germany $u Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio 78229, TX
- 700 1_
- $a Mata, Ignacio $u Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland 44196, OH
- 700 1_
- $a Ruiz, Agustín $u Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona 08029, Spain $u Networking Research Center on Neurodegenerative Diseases (CIRNED), Instituto de Salud Carlos III, Madrid 28029, Spain
- 700 1_
- $a Gan-Or, Ziv $u The Neuro (Montreal Neurological Institute-Hospital), Montreal, Quebec H3A 2B4, Canada $u Department of Human Genetics, McGill University, Montreal, Quebec H3A 0G4, Canada $u Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 0G4, Canada
- 700 1_
- $a Lambert, Jean-Charles $u Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liés au vieillissement, Lille 59000, France
- 700 1_
- $a Greicius, Michael D $u Department of Neurology and Neurological Sciences, Stanford University, Stanford 94305, CA
- 700 1_
- $a Mignot, Emmanuel $u Center for Sleep Sciences and Medicine, Stanford University, Palo Alto 94304, CA $1 https://orcid.org/0000000269285310
- 710 2_
- $a EADB
- 710 2_
- $a GR@ACE study group
- 710 2_
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- 710 2_
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- 710 2_
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- 710 2_
- $a GERAD
- 710 2_
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