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Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma
G. Molteni, R. Nocini, F. Mattioli, M. Nakayama, RA. Dedivitis, G. Mannelli, E. Crosetti, CM. Chiesa-Estomba, JA. Sistiaga-Suarez, L. Giordano, A. Galli, M. Lionello, G. Mercante, M. Ralli, M. Fermi, A. Klein-Rodríguez, M. Mayo-Yáñez, E....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
Odkazy
PubMed
37496499
DOI
10.1002/hed.27471
Knihovny.cz E-zdroje
- MeSH
- dlaždicobuněčné karcinomy hlavy a krku patologie MeSH
- lidé MeSH
- lymfadenektomie MeSH
- lymfatické metastázy patologie MeSH
- lymfatické uzliny * patologie MeSH
- nádory hlavy a krku * patologie MeSH
- poměr lymfatických uzlin MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- staging nádorů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
INTRODUCTION: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. MATERIALS AND METHODS: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. RESULTS: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. CONCLUSION: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.
Department of Biomedical Sciences Humanitas University Milan Italy
Department of Experimental and Clinical Medicine University of Florence Florence Italy
Department of Head and Neck and Sensory Organs Università Cattolica del Sacro Cuore Rome Italy
Department of Head and Neck Surgery Cancer Institute of São Paulo ICESP São Paulo Brazil
Department of Head and Neck Surgery University of São Paulo Medical School São Paulo Brazil
Department of Head and Neck Surgery University of Sao Paulo School of Medicine Sao Paulo Brazil
Department of Otolaryngology Head and Neck Surgery University Hospital of Verona Verona Italy
Department of Otolaryngology Yokosuka Kyosai Hospital Yokohama Japan
Department of Otorhinolaryngology Head and Neck Surgery University Hospital of Modena Modena Italy
Department of Otorhinolaryngology San Luigi Gonzaga Hospital University of Turin Turin Italy
Department of Otorhinolaryngology University Hospital of Jerez Cádiz Spain
Department of Sense Organs Sapienza University of Rome Rome Italy
Department of Surgical Sciences and Integrated Diagnostics University of Genoa Genoa Italy
Unit of Otolaryngology Head and Neck Surgery San Giovanni Bosco Hospital Turin Italy
Unit of Otorhinolaryngology Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy
Unit of Otorhinolaryngology IRCCS Humanitas Research Hospital Milan Italy
Unit of Otorhinolaryngology Vittorio Veneto Hospital Vittorio Veneto Italy
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- $a Molteni, Gabriele $u Department of Otolaryngology - Head and Neck Surgery, University Hospital of Verona, Verona, Italy $u Unit of Otolaryngology, Department of Surgery, Dentistry and Pediatrics, University of Verona, Verona, Italy $1 https://orcid.org/0000000177642122
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- $a Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma / $c G. Molteni, R. Nocini, F. Mattioli, M. Nakayama, RA. Dedivitis, G. Mannelli, E. Crosetti, CM. Chiesa-Estomba, JA. Sistiaga-Suarez, L. Giordano, A. Galli, M. Lionello, G. Mercante, M. Ralli, M. Fermi, A. Klein-Rodríguez, M. Mayo-Yáñez, E. Serafini, F. Pirola, A. Paderno, F. Cambria, N. Oridate, D. Sano, P. Boscolo-Rizzo, AV. Marcuzzo, G. Parrinello, F. Marchi, AM. Saibene, M. Tucciarone, G. Viscasillas, K. Zeleník, DM. Ramos, J. Palacios-Garcia, G. Tirelli, R. Pellini, G. Paludetti, J. Galli, G. Rossi, M. De Vincentiis, CR. Cernea, G. Spriano, M. Bussi, G. Peretti, G. Succo, C. Piazza, A. Bertolin, LP. Kowalski, L. Presutti, A. Sacchetto
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- $a INTRODUCTION: The aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. MATERIALS AND METHODS: We conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. RESULTS: 2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. CONCLUSION: Our data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.
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