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Galectin-targeting glycocalix[4]arenes can enter the cells

M. Vlachová, VN. Tran, J. Červený, F. Dolníček, L. Petrásková, H. Pelantová, O. Kundrát, J. Cvačka, Z. Bosáková, V. Křen, P. Lhoták, J. Viktorová, P. Bojarová

. 2023 ; 59 (69) : 10404-10407. [pub] 20230824

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23016511

Elevated levels of galectin-3 are associated with tumorigenesis. Its inhibition with high-affinity carbohydrate ligands opens new therapeutic routes. Targeting of intracellular galectin-3 is challenging for polar inhibitors like carbohydrates. We demonstrate the potential of novel biomedical research tools, glycocalix[4]arenes, to enter epithelial cells, which may allow their interaction with galectin-3.

Citace poskytuje Crossref.org

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$a Elevated levels of galectin-3 are associated with tumorigenesis. Its inhibition with high-affinity carbohydrate ligands opens new therapeutic routes. Targeting of intracellular galectin-3 is challenging for polar inhibitors like carbohydrates. We demonstrate the potential of novel biomedical research tools, glycocalix[4]arenes, to enter epithelial cells, which may allow their interaction with galectin-3.
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$a Dolníček, František $u University of Chemistry and Technology Prague, Technická 5, CZ-16628 Praha 6, Czech Republic. prokesoj@vscht.cz
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$a Kundrát, Ondřej $u University of Chemistry and Technology Prague, Technická 5, CZ-16628 Praha 6, Czech Republic. prokesoj@vscht.cz
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$a Bosáková, Zuzana $u Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, CZ-12843 Praha 2, Czech Republic
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