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Synthesis and characterization of TiO2 nanoparticles combined with geraniol and their synergistic antibacterial activity
AB. Younis, V. Milosavljevic, T. Fialova, K. Smerkova, H. Michalkova, P. Svec, P. Antal, P. Kopel, V. Adam, L. Zurek, K. Dolezelikova
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
BioMedCentral Open Access od 2001
Directory of Open Access Journals od 2001
Free Medical Journals od 2001
PubMed Central od 2001
Europe PubMed Central od 2001
ProQuest Central od 2009-01-01
Open Access Digital Library od 2001-01-01
Open Access Digital Library od 2001-01-01
Open Access Digital Library od 2001-02-01
Medline Complete (EBSCOhost) od 2001-01-01
Health & Medicine (ProQuest) od 2009-01-01
Springer Journals Complete - Open Access od 2001-12-01
Springer Nature OA/Free Journals od 2001-12-01
Odkazy
PubMed
37528354
DOI
10.1186/s12866-023-02955-1
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- Bacteria MeSH
- kovové nanočástice * MeSH
- methicilin rezistentní Staphylococcus aureus * MeSH
- mikrobiální testy citlivosti MeSH
- nanočástice * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: The emergence of antibiotic resistance in pathogenic bacteria has become a global threat, encouraging the adoption of efficient and effective alternatives to conventional antibiotics and promoting their use as replacements. Titanium dioxide nanoparticles (TiO2 NPs) have been reported to exhibit antibacterial properties. In this study, we synthesized and characterized TiO2 NPs in anatase and rutile forms with surface modification by geraniol (GER). RESULTS: The crystallinity and morphology of modified TiO2 NPs were analyzed by UV/Vis spectrophotometry, X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) with elemental mapping (EDS). The antimicrobial activity of TiO2 NPs with geraniol was assessed against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia coli. The minimum inhibitory concentration (MIC) values of modified NPs ranged from 0.25 to 1.0 mg/ml against all bacterial strains, and the live dead assay and fractional inhibitory concentration (FIC) supported the antibacterial properties of TiO2 NPs with GER. Moreover, TiO2 NPs with GER also showed a significant decrease in the biofilm thickness of MRSA. CONCLUSIONS: Our results suggest that TiO2 NPs with GER offer a promising alternative to antibiotics, particularly for controlling antibiotic-resistant strains. The surface modification of TiO2 NPs by geraniol resulted in enhanced antibacterial properties against multiple bacterial strains, including antibiotic-resistant MRSA. The potential applications of modified TiO2 NPs in the biomedical and environmental fields warrant further investigation.
Department of Chemistry and Biochemistry Mendel University in Brno Brno Czech Republic
Department of Inorganic Chemistry Faculty of Science Palacky University Olomouc Czech Republic
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- $a Younis, Almotasem Bellah $u Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic
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- $a BACKGROUND: The emergence of antibiotic resistance in pathogenic bacteria has become a global threat, encouraging the adoption of efficient and effective alternatives to conventional antibiotics and promoting their use as replacements. Titanium dioxide nanoparticles (TiO2 NPs) have been reported to exhibit antibacterial properties. In this study, we synthesized and characterized TiO2 NPs in anatase and rutile forms with surface modification by geraniol (GER). RESULTS: The crystallinity and morphology of modified TiO2 NPs were analyzed by UV/Vis spectrophotometry, X-ray powder diffraction (XRD), and scanning electron microscopy (SEM) with elemental mapping (EDS). The antimicrobial activity of TiO2 NPs with geraniol was assessed against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia coli. The minimum inhibitory concentration (MIC) values of modified NPs ranged from 0.25 to 1.0 mg/ml against all bacterial strains, and the live dead assay and fractional inhibitory concentration (FIC) supported the antibacterial properties of TiO2 NPs with GER. Moreover, TiO2 NPs with GER also showed a significant decrease in the biofilm thickness of MRSA. CONCLUSIONS: Our results suggest that TiO2 NPs with GER offer a promising alternative to antibiotics, particularly for controlling antibiotic-resistant strains. The surface modification of TiO2 NPs by geraniol resulted in enhanced antibacterial properties against multiple bacterial strains, including antibiotic-resistant MRSA. The potential applications of modified TiO2 NPs in the biomedical and environmental fields warrant further investigation.
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- $a Dolezelikova, Kristyna $u Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic. kriki.cihalova@seznam.cz
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