Cellular senescence leads to decreased tissue regeneration and inflammation and is associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the mechanisms of cellular senescence are not fully understood. Emerging evidence has indicated that c-Jun N-terminal kinase (JNK) signaling is involved in the regulation of cellular senescence. JNK can downregulate hypoxia inducible factor-1α to accelerate hypoxia-induced neuronal cell senescence. The activation of JNK inhibits mTOR activity and triggers autophagy, which promotes cellular senescence. JNK can upregulate the expression of p53 and Bcl-2 and accelerates cancer cell senescence; however, this signaling also mediates the expression of amphiregulin and PD-LI to achieve cancer cell immune evasion and prevents their senescence. The activation of JNK further triggers forkhead box O expression and its target gene Jafrac1 to extend the lifespan of Drosophila. JNK can also upregulate the expression of DNA repair protein poly ADP-ribose polymerase 1 and heat shock protein to delay cellular senescence. This review discusses recent advances in understanding the function of JNK signaling in cellular senescence and includes a comprehensive analysis of the molecular mechanisms underlying JNK-mediated senescence evasion and oncogene-induced cellular senescence. We also summarize the research progress in anti-aging agents that target JNK signaling. This study will contribute to a better understanding of the molecular targets of cellular senescence and provides insights into anti-aging, which may be used to develop drugs for the treatment of aging-related diseases.

Andalusian Research Institute in Data Science and Computational Intelligence University of Granada Granada Spain

Central European Institute of Technology Brno University of Technology Brno 602 00 Czech Republic

College of Life Science Yangtze University Jingzhou 434025 China

Department of Chemistry and Biochemistry Mendel University in Brno Brno 613 00 Czech Republic

Department of Chemistry Faculty of Science University of Hradec Králové 500 03 Hradec Králové Czech Republic

Faculty of Chemical and Food Technology Slovak University of Technology 812 37 Bratislava Slovakia

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro Products Key Laboratory of Traceability for Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

Citace poskytuje Crossref.org