Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-?B/MAPK Signaling Pathway in Rats

X. Zong, Q. Ding, X. Liu, Q. Liu, S. Song, X. Yan, Y. Zhang

. 2023 ; 72 (4) : 445-454. [pub] 2023Aug31

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc23018223

This analysis aims to see whether 6-shogaol could protect rats against D-galactosamine (D-GalN)-induced Hepatotoxicity. The Wistar rats were divided into four groups (n=6). Group 1 received a standard diet, Group 2 received an oral administration of 6-shogaol (20 mg/kg b.wt), Group 3 received an intraperitoneal injection of D-GalN (400 mg/kg b.wt) on 21st day, and Group 4 received an oral administration of 6-shogaol (20mg/kg b.wt) for 21 days and D-GalN (400 mg/kg b.wt) injection only on 21st day. The hepatic marker enzymes activity, lipid peroxidative markers level increased significantly and antioxidant activity/level significantly reduced in D-GalN-induced rats. 6-shogaol Pretreatment effectively improves the above changes in D-GalN-induced rats. Further, inflammatory marker expression and MAPK signaling molecules were downregulated by 6-shogaol. These findings showed that 6-shogaol exerts hepatoprotective effects via the enhanced antioxidant system and attenuated the inflammation and MAPK signaling pathway in D-GalN-induced rats.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23018223
003      
CZ-PrNML
005      
20231116090657.0
007      
ta
008      
231107s2023 xr da f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.935092 $2 doi
035    __
$a (PubMed)37795887
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Zong, Xiufang $u Department of Clinical Laboratory, Baoding First Central Hospital, Baoding, Hebei province, China
245    10
$a Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-?B/MAPK Signaling Pathway in Rats / $c X. Zong, Q. Ding, X. Liu, Q. Liu, S. Song, X. Yan, Y. Zhang
520    9_
$a This analysis aims to see whether 6-shogaol could protect rats against D-galactosamine (D-GalN)-induced Hepatotoxicity. The Wistar rats were divided into four groups (n=6). Group 1 received a standard diet, Group 2 received an oral administration of 6-shogaol (20 mg/kg b.wt), Group 3 received an intraperitoneal injection of D-GalN (400 mg/kg b.wt) on 21st day, and Group 4 received an oral administration of 6-shogaol (20mg/kg b.wt) for 21 days and D-GalN (400 mg/kg b.wt) injection only on 21st day. The hepatic marker enzymes activity, lipid peroxidative markers level increased significantly and antioxidant activity/level significantly reduced in D-GalN-induced rats. 6-shogaol Pretreatment effectively improves the above changes in D-GalN-induced rats. Further, inflammatory marker expression and MAPK signaling molecules were downregulated by 6-shogaol. These findings showed that 6-shogaol exerts hepatoprotective effects via the enhanced antioxidant system and attenuated the inflammation and MAPK signaling pathway in D-GalN-induced rats.
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a zvířata $7 D000818
650    _2
$a potkani Wistar $7 D017208
650    12
$a galaktosamin $x toxicita $7 D005688
650    _2
$a játra $x metabolismus $7 D008099
650    _2
$a signální transdukce $7 D015398
650    _2
$a antioxidancia $x farmakologie $x metabolismus $7 D000975
650    12
$a lékové postižení jater $x prevence a kontrola $x metabolismus $7 D056486
650    _2
$a lipopolysacharidy $x metabolismus $7 D008070
655    _2
$a časopisecké články $7 D016428
700    1_
$a Ding, Qian $u Department of Gastroenterology, Baoding First Central Hospital, Baoding, Hebei province, China
700    1_
$a Liu, Xu $u Department of Gastroenterology, Baoding First Central Hospital, Baoding, Hebei province, China
700    1_
$a Liu, Qianqian $u Department of Gastroenterology, Baoding First Central Hospital, Baoding, Hebei province, China
700    1_
$a Song, Shichao $u Department of Gastroenterology, Baoding First Central Hospital, Baoding, Hebei province, China
700    1_
$a Yan, Xu $u Department of Gastroenterology, Baoding First Central Hospital, Baoding, Hebei province, China
700    1_
$a Zhang, Yan $u Department of Gastroenterology, Baoding First Central Hospital, Baoding, Hebei province, China
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 72, č. 4 (2023), s. 445-454
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37795887 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20231107 $b ABA008
991    __
$a 20231116090652 $b ABA008
999    __
$a ok $b bmc $g 2009501 $s 1204626
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 72 $c 4 $d 445-454 $e 2023Aug31 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK198 $a Pubmed-20231107

Find record

Citation metrics

Archiving options