Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery

P. Pošta, A. Kolk, K. Pivovarčíková, J. Liška, J. Genčur, O. Moztarzadeh, C. Micopulos, A. Pěnkava, M. Frolo, O. Bissinger, L. Hauer

. 2023 ; 13 (20) : . [pub] 20231010

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23022741

Grantová podpora
00669806 Ministry of Health of the Czech Republic - Conceptual Development of Research Organization (Faculty Hospital in Pilsen - FNPL)
2022-05031 Federal Ministry of Education, Science and Research

In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was tested on a group of 122 patients suffering from OSCC, randomized into a study and a control group enrolled in our study after meeting the inclusion criteria. The preoperative checkup via VELscope, accompanied by the marking of the range of a loss of fluorescence in the study group, was performed before the surgery. We developed a unique mucosal tattoo marking technique for this purpose. The histopathological results after surgical treatment, i.e., the margin status, were then compared. In the study group, we achieved pathological free margin (pFM) in 55 patients, pathological close margin (pCM) in 6 cases, and we encountered no cases of pathological positive margin (pPM) in the mucosal layer. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases, and pFM in 40 of all cases in the mucosal layer. This study demonstrated that preoperative autofluorescence assessment of the mucosal surroundings of OSCC increased the ability to achieve pFM resection 4.8 times in terms of lateral margins.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23022741
003      
CZ-PrNML
005      
20240618111047.0
007      
ta
008      
240105s2023 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/diagnostics13203161 $2 doi
035    __
$a (PubMed)37891982
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Pošta, Petr $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $1 https://orcid.org/0000000346601883
245    10
$a Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery / $c P. Pošta, A. Kolk, K. Pivovarčíková, J. Liška, J. Genčur, O. Moztarzadeh, C. Micopulos, A. Pěnkava, M. Frolo, O. Bissinger, L. Hauer
520    9_
$a In our study, the effect of the use of autofluorescence (Visually Enhanced Lesion Scope-VELscope) on increasing the success rate of surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis was tested on a group of 122 patients suffering from OSCC, randomized into a study and a control group enrolled in our study after meeting the inclusion criteria. The preoperative checkup via VELscope, accompanied by the marking of the range of a loss of fluorescence in the study group, was performed before the surgery. We developed a unique mucosal tattoo marking technique for this purpose. The histopathological results after surgical treatment, i.e., the margin status, were then compared. In the study group, we achieved pathological free margin (pFM) in 55 patients, pathological close margin (pCM) in 6 cases, and we encountered no cases of pathological positive margin (pPM) in the mucosal layer. In comparison, the control group results revealed pPM in 7 cases, pCM in 14 cases, and pFM in 40 of all cases in the mucosal layer. This study demonstrated that preoperative autofluorescence assessment of the mucosal surroundings of OSCC increased the ability to achieve pFM resection 4.8 times in terms of lateral margins.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kolk, Andreas $u Department of Oral and Maxillofacial Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria
700    1_
$a Pivovarčíková, Kristýna $u Sikl's Department of Pathology, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $u Bioptic Laboratory Ltd., 32600 Pilsen, Czech Republic
700    1_
$a Liška, Jan $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $1 https://orcid.org/0000000273151681
700    1_
$a Genčur, Jiří $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic
700    1_
$a Moztarzadeh, Omid $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $u Department of Anatomy, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $1 https://orcid.org/0000000247682382
700    1_
$a Micopulos, Christos $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $7 xx0318572
700    1_
$a Pěnkava, Adam $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic $7 xx0318571
700    1_
$a Frolo, Maria $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic
700    1_
$a Bissinger, Oliver $u Department of Oral and Maxillofacial Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria
700    1_
$a Hauer, Lukáš $u Department of Stomatology, University Hospital Pilsen, Faculty of Medicine, Charles University, 32300 Pilsen, Czech Republic
773    0_
$w MED00195450 $t Diagnostics $x 2075-4418 $g Roč. 13, č. 20 (2023)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37891982 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240105 $b ABA008
991    __
$a 20240618111048 $b ABA008
999    __
$a ok $b bmc $g 2036375 $s 1209186
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 13 $c 20 $e 20231010 $i 2075-4418 $m Diagnostics $n Diagnostics $x MED00195450
GRA    __
$a 00669806 $p Ministry of Health of the Czech Republic - Conceptual Development of Research Organization (Faculty Hospital in Pilsen - FNPL)
GRA    __
$a 2022-05031 $p Federal Ministry of Education, Science and Research
LZP    __
$a Pubmed-20240105

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace