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Serum identification of at-risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF)
M. Noureddin, E. Truong, R. Mayo, I. Martínez-Arranz, I. Mincholé, JM. Banales, M. Arrese, K. Cusi, MT. Arias-Loste, R. Bruha, M. Romero-Gómez, P. Iruzubieta, R. Aller, J. Ampuero, JL. Calleja, L. Ibañez-Samaniego, P. Aspichueta, A. Martín-Duce,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Odkazy
PubMed
37505221
DOI
10.1097/hep.0000000000000542
Knihovny.cz E-zdroje
- MeSH
- biopsie škodlivé účinky MeSH
- elastografie * MeSH
- fibróza MeSH
- jaterní cirhóza patologie MeSH
- játra diagnostické zobrazování patologie MeSH
- lidé MeSH
- nealkoholová steatóza jater * patologie MeSH
- prediktivní hodnota testů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Early identification of those with NAFLD activity score ≥ 4 and significant fibrosis (≥F2) or at-risk metabolic dysfunction-associated steatohepatitis (MASH) is a priority as these patients are at increased risk for disease progression and may benefit from therapies. We developed and validated a highly specific metabolomics-driven score to identify at-risk MASH. METHODS: We included derivation (n = 790) and validation (n = 565) cohorts from international tertiary centers. Patients underwent laboratory assessment and liver biopsy for metabolic dysfunction-associated steatotic liver disease. Based on 12 lipids, body mass index, aspartate aminotransferase, and alanine aminotransferase, the MASEF score was developed to identify at-risk MASH and compared to the FibroScan-AST (FAST) score. We further compared the performance of a FIB-4 + MASEF algorithm to that of FIB-4 + liver stiffness measurements (LSM) by vibration-controlled transient elastography (VCTE). RESULTS: The diagnostic performance of the MASEF score showed an area under the receiver-operating characteristic curve, sensitivity, specificity, and positive and negative predictive values of 0.76 (95% CI 0.72-0.79), 0.69, 0.74, 0.53, and 0.85 in the derivation cohort, and 0.79 (95% CI 0.75-0.83), 0.78, 0.65, 0.48, and 0.88 in the validation cohort, while FibroScan-AST performance in the validation cohort was 0.74 (95% CI 0.68-0.79; p = 0.064), 0.58, 0.79, 0.67, and 0.73, respectively. FIB-4+MASEF showed similar overall performance compared with FIB-4 + LSM by VCTE ( p = 0.69) to identify at-risk MASH. CONCLUSION: MASEF is a promising diagnostic tool for the assessment of at-risk MASH. It could be used alternatively to LSM by VCTE in the algorithm that is currently recommended by several guidance publications.
Biocruces Bizkaia Health Research Institute Barakaldo Spain
CIC bioGUNE Basque Research and Technology Alliance Derio Spain
Clinic University Hospital University of Valladolid Valladolid Spain
Department of Biochemistry and Genetics School of Sciences University of Navarra Pamplona Spain
Division of Liver Diseases Icahn School of Medicine at Mount Sinai New York City New York USA
General University Hospital and the 1st Faculty of Medicine Charles University Prague Czech Republic
Gregorio Marañón University Hospital Madrid Spain
Houston Methodist Hospital Houston Research Institute Houston Texas USA
Houston Research Institute Houston Texas USA
Karsh Division of Gastroenterology and Hepatology Cedars Sinai Medical Center Los Angeles CA
Marqués de Valdecilla University Hospital Cantabria University IDIVAL Santander Spain
National Institute for the Study of Liver and Gastrointestinal Diseases Madrid Spain
Pinnacle Clinical Research San Antonio Texas USA
Príncipe de Asturias University Hospital Alcalá University Madrid Spain
Puerta del Hierro University Hospital Madrid Spain
University of Florida Gainesville Florida USA
Valme University Hospital CIBERehd Seville Spain
Virgen del Rocío University Hospital Sevilla Spain
Virginia Commonwealth University Medical Center Richmond Virginia USA
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