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Independent loss events of a functional tetherin gene in galliform birds
V. Krchlíková, R. Lotke, I. Haußmann, M. Reinišová, D. Kučerová, Ľ. Pecnová, L. Ungrová, J. Hejnar, D. Sauter, D. Elleder
Language English Country United States
Document type Journal Article
Grant support
20-22063S
Grantová Agentura České Republiky (GAČR)
SA 2676/1-2
Deutsche Forschungsgemeinschaft (DFG)
Canon Foundation in Europe (CFE)
COVID-19 research grant
Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (MWK)
NLK
Free Medical Journals
from 1967 to 6 months ago
Freely Accessible Science Journals
from 1967 to 6 months ago
PubMed Central
from 1967 to 1 year ago
Europe PubMed Central
from 1967 to 6 months ago
Open Access Digital Library
from 1967-02-01
Open Access Digital Library
from 1967-02-01
PubMed
37712707
DOI
10.1128/jvi.00803-23
Knihovny.cz E-resources
- MeSH
- Bone Marrow Stromal Antigen 2 * genetics MeSH
- Biological Evolution MeSH
- Antigens, CD * genetics metabolism MeSH
- GPI-Linked Proteins genetics MeSH
- Birds MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Birds represent important hosts for numerous viruses, including zoonotic viruses and pathogens with the potential to cause major economic losses to the poultry industry. Viral replication and transmission can be inhibited or blocked by the action of antiviral restriction factors (RFs) encoded by the host. One well-characterized RF is tetherin, a protein that directly blocks the release of newly formed viral particles from infected cells. Here, we describe the evolutionary loss of a functional tetherin gene in two galliform birds, turkey (Meleagris gallopavo) and Mikado pheasant (Syrmaticus mikado). Moreover, we demonstrate that the structurally related protein TMCC(aT) exerts antiviral activity in several birds, albeit by a mechanism different from that of tetherin. The evolutionary scenario described here represents the first documented loss-of-tetherin cases in vertebrates.
References provided by Crossref.org
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