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Independent loss events of a functional tetherin gene in galliform birds
V. Krchlíková, R. Lotke, I. Haußmann, M. Reinišová, D. Kučerová, Ľ. Pecnová, L. Ungrová, J. Hejnar, D. Sauter, D. Elleder
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
20-22063S
Grantová Agentura České Republiky (GAČR)
SA 2676/1-2
Deutsche Forschungsgemeinschaft (DFG)
Canon Foundation in Europe (CFE)
COVID-19 research grant
Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (MWK)
NLK
Free Medical Journals
od 1967 do Před 6 měsíci
Freely Accessible Science Journals
od 1967 do Před 6 měsíci
PubMed Central
od 1967 do Před 1 rokem
Europe PubMed Central
od 1967 do Před 6 měsíci
Open Access Digital Library
od 1967-02-01
Open Access Digital Library
od 1967-02-01
PubMed
37712707
DOI
10.1128/jvi.00803-23
Knihovny.cz E-zdroje
- MeSH
- antigen stromálních buněk kostní dřeně * genetika MeSH
- biologická evoluce MeSH
- CD antigeny * genetika metabolismus MeSH
- GPI-vázané proteiny genetika MeSH
- ptáci MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Birds represent important hosts for numerous viruses, including zoonotic viruses and pathogens with the potential to cause major economic losses to the poultry industry. Viral replication and transmission can be inhibited or blocked by the action of antiviral restriction factors (RFs) encoded by the host. One well-characterized RF is tetherin, a protein that directly blocks the release of newly formed viral particles from infected cells. Here, we describe the evolutionary loss of a functional tetherin gene in two galliform birds, turkey (Meleagris gallopavo) and Mikado pheasant (Syrmaticus mikado). Moreover, we demonstrate that the structurally related protein TMCC(aT) exerts antiviral activity in several birds, albeit by a mechanism different from that of tetherin. The evolutionary scenario described here represents the first documented loss-of-tetherin cases in vertebrates.
Citace poskytuje Crossref.org
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