Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
PubMed
39275807
DOI
10.1093/mutage/geae023
PII: 7756926
Knihovny.cz E-zdroje
- Klíčová slova
- MicroRNA, biomarker, chemoresistance, colon cancer, liquid biopsy,
- MeSH
- chemorezistence * genetika MeSH
- fluoruracil terapeutické užití MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA * krev genetika MeSH
- nádorové biomarkery krev genetika MeSH
- nádory tračníku * farmakoterapie genetika krev patologie MeSH
- prognóza MeSH
- regulace genové exprese u nádorů MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- fluoruracil MeSH
- mikro RNA * MeSH
- MIRN122 microRNA, human MeSH Prohlížeč
- MIRN142 microRNA, human MeSH Prohlížeč
- nádorové biomarkery MeSH
Chemoresistance represents a major issue affecting cancer therapy efficacy. Because microRNAs (miRNAs) regulate gene expression on multiple levels, their role in chemoresistance development is reasonably certain. In our previous study, miR-122-5p and miR-142-5p were identified as diagnostic, prognostic, and predictive biomarkers for primary and metastatic rectal cancer. The aim of the present study was to investigate whether these miRNAs can also reflect the disease course of patients with colon cancer (CC). Further, we focused on a deeper understanding of their involvement in 5-fluorouracil (5-FU) chemoresistance development.
1st Medical Faculty Charles University Prague 142 20 Czech Republic
3rd Faculty of Medicine Charles University Ruska 87 Prague 10000 Czech Republic
Citace poskytuje Crossref.org
Commentary: Special Issue: Current Understanding of Colorectal and Pancreatic Cancers
