Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of patients with colon cancer
Language English Country England, Great Britain Media print
Document type Journal Article
PubMed
39275807
DOI
10.1093/mutage/geae023
PII: 7756926
Knihovny.cz E-resources
- Keywords
- MicroRNA, biomarker, chemoresistance, colon cancer, liquid biopsy,
- MeSH
- Drug Resistance, Neoplasm * genetics MeSH
- Fluorouracil therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- MicroRNAs * blood genetics MeSH
- Biomarkers, Tumor blood genetics MeSH
- Colonic Neoplasms * drug therapy genetics blood pathology MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Fluorouracil MeSH
- MicroRNAs * MeSH
- MIRN122 microRNA, human MeSH Browser
- MIRN142 microRNA, human MeSH Browser
- Biomarkers, Tumor MeSH
Chemoresistance represents a major issue affecting cancer therapy efficacy. Because microRNAs (miRNAs) regulate gene expression on multiple levels, their role in chemoresistance development is reasonably certain. In our previous study, miR-122-5p and miR-142-5p were identified as diagnostic, prognostic, and predictive biomarkers for primary and metastatic rectal cancer. The aim of the present study was to investigate whether these miRNAs can also reflect the disease course of patients with colon cancer (CC). Further, we focused on a deeper understanding of their involvement in 5-fluorouracil (5-FU) chemoresistance development.
1st Medical Faculty Charles University Prague 142 20 Czech Republic
3rd Faculty of Medicine Charles University Ruska 87 Prague 10000 Czech Republic
References provided by Crossref.org
Commentary: Special Issue: Current Understanding of Colorectal and Pancreatic Cancers
