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Je něco špatně v tomto záznamu ?
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
M. Thomas, YR. Su, EA. Rosenthal, LC. Sakoda, SL. Schmit, MN. Timofeeva, Z. Chen, C. Fernandez-Rozadilla, PJ. Law, N. Murphy, R. Carreras-Torres, V. Diez-Obrero, FJB. van Duijnhoven, S. Jiang, A. Shin, A. Wolk, AI. Phipps, A. Burnett-Hartman, A....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural
Grantová podpora
P30 CA008748
NCI NIH HHS - United States
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- celogenomová asociační studie MeSH
- etnicita * genetika MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus MeSH
- kolorektální nádory * diagnóza genetika MeSH
- lidé MeSH
- multifaktoriální dědičnost MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice.
Biostatistics Division Kaiser Permanente Washington Health Research Institute Seattle USA
Broad Institute of Harvard and MIT Cambridge MA USA
Cancer Epidemiology Division Cancer Council Victoria Melbourne VIC Australia
Cancer Epidemiology Program H Lee Moffitt Cancer Center and Research Institute Tampa FL USA
Center for Cancer Research Medical University Vienna Vienna Austria
Center for Gastrointestinal Biology and Disease University of North Carolina Chapel Hill NC USA
Center for Public Health Genomics University of Virginia Charlottesville VA USA
CIBER Epidemiología y Salud Pública Madrid Spain
Department of Biostatistics School of Public Health Nanjing Medical University Nanjing China
Department of Biostatistics University of Washington Seattle WA USA
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona 08908 Spain
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain
Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center Haifa Israel
Department of Environmental Health Harvard T H Chan School of Public Health Boston MA USA
Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA
Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA
Department of Epidemiology Harvard T H Chan School of Public Health Harvard University Boston MA USA
Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Epidemiology University of Washington School of Public Health Seattle WA USA
Department of Epidemiology University of Washington Seattle WA USA
Department of Family Medicine University of Virginia Charlottesville VA USA
Department of Gastroenterology Kaiser Permanente Medical Center San Francisco CA USA
Department of Gastroenterology Kaiser Permanente San Francisco Medical Center San Francisco CA USA
Department of Internal Medicine University of Utah Salt Lake City UT USA
Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Scottsdale AZ USA
Department of Medicine 1 University Hospital Dresden Technische Universität Dresden Dresden Germany
Department of Medicine and Epidemiology University of Pittsburgh Medical Center Pittsburgh PA USA
Department of Medicine and Surgery LUM University Camassima Italy
Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA
Department of Medicine University of Washington Medical Center Seattle WA 98195 USA
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Pathology University of Michigan Ann Arbor MI 48104 USA
Department of Population Science American Cancer Society Atlanta GA USA
Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Department of Public Health Erasmus University Medical Center Rotterdam The Netherlands
Department of Radiation Sciences Oncology Unit Umeå University Umeå Sweden
Departments of Epidemiology and Nutrition Harvard TH Chan School of Public Health Boston MA USA
Digestive Diseases and Microbiota Group Girona Biomedical Research Institute Salt 17190 Girona Spain
Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston MA USA
Division of Genetics and Epidemiology The Institute of Cancer Reseach London SW7 3RP UK
Division of Human Nutrition and Health Wageningen University and Research Wageningen The Netherlands
Division of Molecular and Clinical Epidemiology Aichi Cancer Center Research Institute Nagoya Japan
Division of Preventive Oncology German Cancer Research Center Heidelberg Germany
Division of Research Kaiser Permanente Northern California Oakland CA USA
Duke Molecular Physiology Institute Duke University Medical Center Durham NC USA
Faculty of Medicine and Biomedical Center in Pilsen Charles University Pilsen Czech Republic
Gastrointestinal Genetics Lab CIC bioGUNE BRTA Derio Spain
Genomic Medicine and Family Cancer Clinic The Royal Melbourne Hospital Parkville VIC 3000 Australia
Genomic Medicine Institute Cleveland Clinic Cleveland OH USA
Institute for Health Promotion Graduate School of Public Health Yonsei University Seoul Korea
Institute for Health Research Kaiser Permanente Colorado Denver CO USA
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Instituto de Investigacion Sanitaria de Santiago Choupana sn 15706 Santiago de Compostela Spain
Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun Korea
Leeds Institute of Cancer and Pathology University of Leeds Leeds UK
Memorial University of Newfoundland Discipline of Genetics St John's Canada
Moffitt Cancer Center Tampa FL USA
Nantes Université CHU Nantes Service de Génétique Médicale F 44000 Nantes France
National University Cancer Institute Singapore Singapore
ONCOBEL Program Bellvitge Biomedical Research Institute L'Hospitalet de Llobregat Barcelona Spain
Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland USA
Public Health Sciences Division Fred Hutchinson Cancer Center Seattle WA 98109 USA
Research Institute and Hospital National Cancer Center Goyang South Korea South Korea
Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel
Samuel Oschin Comprehensive Cancer Institute CEDARS SINAI Los Angeles CA USA
Slone Epidemiology Center School of Medicine Boston University Boston MA USA
State Key Laboratory of Oncology in South China Cancer Center Sun Yat sen University Guangzhou China
SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle WA USA
University Medical Centre Hamburg Eppendorf University Cancer Centre Hamburg Hamburg Germany
University of Hawaii Cancer Center Honolulu HI USA
University of Southern California Preventative Medicine Los Angeles CA USA
Vanderbilt University Medical Center Nashville TN USA
Wallenberg Centre for Molecular Medicine Umeå University Umeå Sweden
Citace poskytuje Crossref.org
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