Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Cellular activation pathways and interaction networks in vascularized composite allotransplantation

L. Knoedler, S. Knoedler, AC. Panayi, CAA. Lee, S. Sadigh, L. Huelsboemer, VA. Stoegner, A. Schroeter, B. Kern, V. Mookerjee, CG. Lian, SG. Tullius, GF. Murphy, B. Pomahac, M. Kauke-Navarro

. 2023 ; 14 (-) : 1179355. [pub] 20230517

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc24003198

Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive surgery that has revolutionized the treatment of patients with devastating injuries, including those with limb losses or facial disfigurement. The transplanted units are typically comprised of different tissue types, including skin, mucosa, blood and lymphatic vasculature, muscle, and bone. It is widely accepted that the antigenicity of some VCA components, such as skin, is particularly potent in eliciting a strong recipient rejection response following transplantation. The fine line between tolerance and rejection of the graft is orchestrated by different cell types, including both donor and recipient-derived lymphocytes, macrophages, and other immune and donor-derived tissue cells (e.g., endothelium). Here, we delineate the role of different cell and tissue types during VCA rejection. Rejection of VCA grafts and the necessity of life-long multidrug immunosuppression remains one of the major challenges in this field. This review sheds light on recent developments in decoding the cellular signature of graft rejection in VCA and how these may, ultimately, influence the clinical management of VCA patients by way of novel therapies that target specific cellular processes.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24003198
003      
CZ-PrNML
005      
20240509113216.0
007      
ta
008      
240220e20230517sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fimmu.2023.1179355 $2 doi
035    __
$a (PubMed)37266446
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Knoedler, Leonard $u Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States
245    10
$a Cellular activation pathways and interaction networks in vascularized composite allotransplantation / $c L. Knoedler, S. Knoedler, AC. Panayi, CAA. Lee, S. Sadigh, L. Huelsboemer, VA. Stoegner, A. Schroeter, B. Kern, V. Mookerjee, CG. Lian, SG. Tullius, GF. Murphy, B. Pomahac, M. Kauke-Navarro
520    9_
$a Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive surgery that has revolutionized the treatment of patients with devastating injuries, including those with limb losses or facial disfigurement. The transplanted units are typically comprised of different tissue types, including skin, mucosa, blood and lymphatic vasculature, muscle, and bone. It is widely accepted that the antigenicity of some VCA components, such as skin, is particularly potent in eliciting a strong recipient rejection response following transplantation. The fine line between tolerance and rejection of the graft is orchestrated by different cell types, including both donor and recipient-derived lymphocytes, macrophages, and other immune and donor-derived tissue cells (e.g., endothelium). Here, we delineate the role of different cell and tissue types during VCA rejection. Rejection of VCA grafts and the necessity of life-long multidrug immunosuppression remains one of the major challenges in this field. This review sheds light on recent developments in decoding the cellular signature of graft rejection in VCA and how these may, ultimately, influence the clinical management of VCA patients by way of novel therapies that target specific cellular processes.
650    _2
$a lidé $7 D006801
650    12
$a vaskularizovaná kompozitní alotransplantace $x škodlivé účinky $7 D063986
650    _2
$a imunologická tolerance $7 D007108
650    _2
$a imunosupresivní léčba $7 D007165
650    _2
$a homologní transplantace $7 D014184
650    _2
$a rejekce štěpu $7 D006084
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Knoedler, Samuel $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States $u Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
700    1_
$a Panayi, Adriana C $u Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States $u Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany
700    1_
$a Lee, Catherine A A $u Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States
700    1_
$a Sadigh, Sam $u Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States
700    1_
$a Huelsboemer, Lioba $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States
700    1_
$a Stoegner, Viola A $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States $u Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center, Hannover Medical School, Hannover, Germany
700    1_
$a Schroeter, Andreas $u Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center, Hannover Medical School, Hannover, Germany $u Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
700    1_
$a Kern, Barbara $u Department of Plastic Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
700    1_
$a Mookerjee, Vikram $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States
700    1_
$a Lian, Christine G $u Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States
700    1_
$a Tullius, Stefan G $u Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
700    1_
$a Murphy, George F $u Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States
700    1_
$a Pomahac, Bohdan $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States
700    1_
$a Kauke-Navarro, Martin $u Division of Plastic Surgery, Department of Surgery, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, United States
773    0_
$w MED00181405 $t Frontiers in immunology $x 1664-3224 $g Roč. 14 (20230517), s. 1179355
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37266446 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240220 $b ABA008
991    __
$a 20240509113210 $b ABA008
999    __
$a ok $b bmc $g 2088854 $s 1212938
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 14 $c - $d 1179355 $e 20230517 $i 1664-3224 $m Frontiers in immunology $n Front Immunol $x MED00181405
LZP    __
$a Pubmed-20240220
Back

Find record

Citation metrics

Archiving options