-
Something wrong with this record ?
Structural biology in antiviral research - a story illustrated by the tales of lipid kinases, STING and viral methyltransferases
Evžen Bouřa
Language English Country Czech Republic
- MeSH
- Antiviral Agents * pharmacology MeSH
- Humans MeSH
- Ligands MeSH
- Methyltransferases pharmacology MeSH
- Protein Kinases MeSH
- Drug Development MeSH
- Check Tag
- Humans MeSH
This article focuses on the role of structural biology in the development of small molecules that serve as protein ligands, which could potentially be used as drugs in the future. Experimental methods are utilized to obtain structural information about proteins, which then allow for virtual screening of extensive libraries of substances. The discovered ligands are further experimentally verified, with structural biology playing a crucial role in their refinement. The goal is to develop a ligand with high affinity and specificity, which could become an effective medicine. This is followed by the optimization of these substances from a chemical and pharmacological standpoint. The entire process is illustrated with examples from the recent past, such as lipid kinases, the stimulator of interferon genes (STING), and viral methyltransferases.
References provided by Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24003943
- 003
- CZ-PrNML
- 005
- 20250219113005.0
- 007
- cr|cn|
- 008
- 240306s2023 xr ac fs 000 0deng||
- 009
- AR
- 024 7_
- $a 10.54779/chl20230755 $2 doi
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Bouřa, Evžen, $d 1980- $7 xx0119184 $u Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Prague, Czech Republic
- 245 10
- $a Structural biology in antiviral research - a story illustrated by the tales of lipid kinases, STING and viral methyltransferases / $c Evžen Bouřa
- 504 __
- $a Literatura
- 520 9_
- $a This article focuses on the role of structural biology in the development of small molecules that serve as protein ligands, which could potentially be used as drugs in the future. Experimental methods are utilized to obtain structural information about proteins, which then allow for virtual screening of extensive libraries of substances. The discovered ligands are further experimentally verified, with structural biology playing a crucial role in their refinement. The goal is to develop a ligand with high affinity and specificity, which could become an effective medicine. This is followed by the optimization of these substances from a chemical and pharmacological standpoint. The entire process is illustrated with examples from the recent past, such as lipid kinases, the stimulator of interferon genes (STING), and viral methyltransferases.
- 650 _7
- $a lidé $7 D006801 $2 czmesh
- 650 17
- $a antivirové látky $x farmakologie $7 D000998 $2 czmesh
- 650 _7
- $a vyvíjení léků $7 D000076722 $2 czmesh
- 650 _7
- $a methyltransferasy $x farmakologie $7 D008780 $2 czmesh
- 650 _7
- $a ligandy $7 D008024 $2 czmesh
- 650 _7
- $a proteinkinasy $7 D011494 $2 czmesh
- 773 0_
- $t Chemické listy $x 0009-2770 $g Roč. 117, č. 12 (2023), s. 755-763 $w MED00011010
- 856 41
- $u http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/4448/4407 $y plný text volně přístupný
- 910 __
- $a ABA008 $b online $c 395 $y p $z 0
- 990 __
- $a 20240305151958 $b ABA008
- 991 __
- $a 20250219113001 $b ABA008
- 999 __
- $a ok $b bmc $g 2059834 $s 1213695
- BAS __
- $a 3 $a 4
- BMC __
- $a 2023 $b 117 $c 12 $d 755-763 $i 0009-2770 $m Chemické listy $x MED00011010
- LZP __
- $c NLK109 $d 20240405 $a NLK 2024-09/kv