Detail
Article
Web resource
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Structural biology in antiviral research - a story illustrated by the tales of lipid kinases, STING and viral methyltransferases

Evžen Bouřa

. 2023 ; 117 (12) : 755-763.

Language English Country Czech Republic

This article focuses on the role of structural biology in the development of small molecules that serve as protein ligands, which could potentially be used as drugs in the future. Experimental methods are utilized to obtain structural information about proteins, which then allow for virtual screening of extensive libraries of substances. The discovered ligands are further experimentally verified, with structural biology playing a crucial role in their refinement. The goal is to develop a ligand with high affinity and specificity, which could become an effective medicine. This is followed by the optimization of these substances from a chemical and pharmacological standpoint. The entire process is illustrated with examples from the recent past, such as lipid kinases, the stimulator of interferon genes (STING), and viral methyltransferases.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc24003943
003      
CZ-PrNML
005      
20250219113005.0
007      
cr|cn|
008      
240306s2023 xr ac fs 000 0deng||
009      
AR
024    7_
$a 10.54779/chl20230755 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Bouřa, Evžen, $d 1980- $7 xx0119184 $u Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Prague, Czech Republic
245    10
$a Structural biology in antiviral research - a story illustrated by the tales of lipid kinases, STING and viral methyltransferases / $c Evžen Bouřa
504    __
$a Literatura
520    9_
$a This article focuses on the role of structural biology in the development of small molecules that serve as protein ligands, which could potentially be used as drugs in the future. Experimental methods are utilized to obtain structural information about proteins, which then allow for virtual screening of extensive libraries of substances. The discovered ligands are further experimentally verified, with structural biology playing a crucial role in their refinement. The goal is to develop a ligand with high affinity and specificity, which could become an effective medicine. This is followed by the optimization of these substances from a chemical and pharmacological standpoint. The entire process is illustrated with examples from the recent past, such as lipid kinases, the stimulator of interferon genes (STING), and viral methyltransferases.
650    _7
$a lidé $7 D006801 $2 czmesh
650    17
$a antivirové látky $x farmakologie $7 D000998 $2 czmesh
650    _7
$a vyvíjení léků $7 D000076722 $2 czmesh
650    _7
$a methyltransferasy $x farmakologie $7 D008780 $2 czmesh
650    _7
$a ligandy $7 D008024 $2 czmesh
650    _7
$a proteinkinasy $7 D011494 $2 czmesh
773    0_
$t Chemické listy $x 0009-2770 $g Roč. 117, č. 12 (2023), s. 755-763 $w MED00011010
856    41
$u http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/4448/4407 $y plný text volně přístupný
910    __
$a ABA008 $b online $c 395 $y p $z 0
990    __
$a 20240305151958 $b ABA008
991    __
$a 20250219113001 $b ABA008
999    __
$a ok $b bmc $g 2059834 $s 1213695
BAS    __
$a 3 $a 4
BMC    __
$a 2023 $b 117 $c 12 $d 755-763 $i 0009-2770 $m Chemické listy $x MED00011010
LZP    __
$c NLK109 $d 20240405 $a NLK 2024-09/kv

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...