Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms

P. Li, J. Dai, Y. Li, D. Alexander, J. Čapek, J. Geis-Gerstorfer, G. Wan, J. Han, Z. Yu, A. Li

. 2024 ; 25 (-) : 100932. [pub] 20231228

Status neindexováno Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc24005525

Bone fractures and critical-size bone defects are significant public health issues, and clinical treatment outcomes are closely related to the intrinsic properties of the utilized implant materials. Zinc (Zn)-based biodegradable metals (BMs) have emerged as promising bioactive materials because of their exceptional biocompatibility, appropriate mechanical properties, and controllable biodegradation. This review summarizes the state of the art in terms of Zn-based metals for bone repair and regeneration, focusing on bridging the gap between biological mechanism and required bioactivity. The molecular mechanism underlying the release of Zn ions from Zn-based BMs in the improvement of bone repair and regeneration is elucidated. By integrating clinical considerations and the specific bioactivity required for implant materials, this review summarizes the current research status of Zn-based internal fixation materials for promoting fracture healing, Zn-based scaffolds for regenerating critical-size bone defects, and Zn-based barrier membranes for reconstituting alveolar bone defects. Considering the significant progress made in the research on Zn-based BMs for potential clinical applications, the challenges and promising research directions are proposed and discussed.

Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Center of Oral Implantology Stomatological Hospital School of Stomatology Southern Medical University South Jiangnan Road No 366 Guangzhou 510280 China

Department of Oral and Maxillofacial Surgery University Hospital Tübingen Osianderstrasse 2 8 Tübingen 72076 Germany

Department of Orthodontics Stomatological Hospital School of Stomatology Southern Medical University South Jiangnan Road No 366 Guangzhou 510280 China

Department of Periodontology Stomatological Hospital School of Stomatology Southern Medical University South Jiangnan Road 366 Guangzhou 510280 China

Department of Prosthodontics School and Hospital of Stomatology Guangzhou Medical University Guangzhou Guangdong 510182 China

FZU the Institute of Physics Czech Academy of Sciences Na Slovance 1999 2 Prague 8 18200 Czech Republic

Institute of Advanced Wear and Corrosion Resistant and Functional Materials Jinan University Guangzhou 510632 China

Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China

National Engineering Laboratory for Digital and Material Technology of Stomatology Department of Dental Materials Peking University School and Hospital of Stomatology Beijing 100081 China

School and Hospital of Stomatology Guangdong Engineering Research Center of Oral Restoration and Reconstruction Guangzhou Medical University Guangzhou Guangdong 510182 China

Section Medical Materials Science and Technology University Hospital Tübingen Osianderstrasse 2 8 Tübingen 72076 Germany

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24005525
003      
CZ-PrNML
005      
20240412130951.0
007      
ta
008      
240405e20231228enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.mtbio.2023.100932 $2 doi
035    __
$a (PubMed)38298560
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Li, Ping $u Center of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, South Jiangnan Road No. 366, Guangzhou 510280, China $u School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China $u Department of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China
245    10
$a Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms / $c P. Li, J. Dai, Y. Li, D. Alexander, J. Čapek, J. Geis-Gerstorfer, G. Wan, J. Han, Z. Yu, A. Li
520    9_
$a Bone fractures and critical-size bone defects are significant public health issues, and clinical treatment outcomes are closely related to the intrinsic properties of the utilized implant materials. Zinc (Zn)-based biodegradable metals (BMs) have emerged as promising bioactive materials because of their exceptional biocompatibility, appropriate mechanical properties, and controllable biodegradation. This review summarizes the state of the art in terms of Zn-based metals for bone repair and regeneration, focusing on bridging the gap between biological mechanism and required bioactivity. The molecular mechanism underlying the release of Zn ions from Zn-based BMs in the improvement of bone repair and regeneration is elucidated. By integrating clinical considerations and the specific bioactivity required for implant materials, this review summarizes the current research status of Zn-based internal fixation materials for promoting fracture healing, Zn-based scaffolds for regenerating critical-size bone defects, and Zn-based barrier membranes for reconstituting alveolar bone defects. Considering the significant progress made in the research on Zn-based BMs for potential clinical applications, the challenges and promising research directions are proposed and discussed.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Dai, Jingtao $u Department of Orthodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, South Jiangnan Road No. 366, Guangzhou 510280, China
700    1_
$a Li, Yageng $u Beijing Advanced Innovation Center for Materials Genome Engineering, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China
700    1_
$a Alexander, Dorothea $u Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, Osianderstrasse 2-8, Tübingen 72076, Germany
700    1_
$a Čapek, Jaroslav $u FZU - the Institute of Physics, Czech Academy of Sciences, Na Slovance 1999/2, Prague 8, 18200, Czech Republic
700    1_
$a Geis-Gerstorfer, Jürgen $u Section Medical Materials Science and Technology, University Hospital Tübingen, Osianderstrasse 2-8, Tübingen 72076, Germany
700    1_
$a Wan, Guojiang $u Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
700    1_
$a Han, Jianmin $u National Engineering Laboratory for Digital and Material Technology of Stomatology, Department of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China
700    1_
$a Yu, Zhentao $u Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou 510632, China
700    1_
$a Li, An $u Department of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, South Jiangnan Road 366, Guangzhou 510280, China
773    0_
$w MED00214249 $t Materials today. Bio $x 2590-0064 $g Roč. 25 (20231228), s. 100932
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38298560 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240405 $b ABA008
991    __
$a 20240412130943 $b ABA008
999    __
$a ok $b bmc $g 2075945 $s 1215287
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2024 $b 25 $c - $d 100932 $e 20231228 $i 2590-0064 $m Materials today. Bio $n Mater Today Bio $x MED00214249
LZP    __
$a Pubmed-20240405

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...