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Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

E. Garcia-Borja, F. Siegl, R. Mateu, O. Slaby, A. Sedo, P. Busek, J. Sana

. 2024 ; 12 (1) : 15. [pub] 20240201

Status neindexováno Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc24005901

Grantová podpora
NV19-03-00501 Ministry of Health of the Czech Republic
NV19-03-00501 Ministry of Health of the Czech Republic
NV19-03-00501 Ministry of Health of the Czech Republic
NV19-03-00501 Ministry of Health of the Czech Republic
LX22NPO5102 European Union
LX22NPO5102 European Union
LX22NPO5102 European Union

Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.

Citace poskytuje Crossref.org

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