BACKGROUND: There is conflicting evidence on the role of acetylsalicylic acid (ASA) use in the development of cardiac allograft vasculopathy (CAV). METHODS: A nationwide prospective two-center study investigated changes in the coronary artery vasculature by highly automated 3-D optical coherence tomography (OCT) analysis at 1 month and 12 months after heart transplant (HTx). The influence of ASA use on coronary artery microvascular changes was analyzed in the overall study cohort and after propensity score matching for selected clinical CAV risk factors. RESULTS: In total, 175 patients (mean age 52 ± 12 years, 79% male) were recruited. During the 1-year follow-up, both intimal and media thickness progressed, with ASA having no effect on its progression. However, detailed OCT analysis revealed that ASA use was associated with a lower increase in lipid plaque (LP) burden (p = .013), while it did not affect the other observed pathologies. Propensity score matching of 120 patients (60 patient pairs) showed similar results, with ASA use associated with lower progression of LPs (p = .002), while having no impact on layered fibrotic plaque (p = .224), calcification (p = .231), macrophage infiltration (p = .197), or the absolute coronary artery risk score (p = .277). According to Kaplan-Meier analysis, ASA use was not associated with a significant difference in survival (p = .699) CONCLUSION: This study showed a benefit of early ASA use after HTx on LP progression. However, ASA use did not have any impact on the progression of other OCT-observed pathologies or long-term survival.

2nd Department of Internal Medicine Department of Cardiovascular Medicine 1st Faculty of Medicine Charles University Prague and General University Hospital Prague Prague Czech Republic

Cardiovascular and Transplantation Surgery Brno Czech Republic

Department of Cardiology IKEM Prague Czech Republic

Department of Cardiovascular Diseases St Anne's University Hospital and Masaryk University Brno Brno Czech Republic

Department of Preventive Cardiology IKEM Prague Czech Republic

Iowa Institute for Biomedical Imaging The University of Iowa Iowa City Iowa USA

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$a Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis / $c L. Mayerova, P. Wohlfahrt, M. Sonka, Z. Chen, J. Kautzner, V. Melenovsky, V. Karmazin, I. Malek, H. Bedanova, A. Tomasek, E. Ozabalova, J. Krejci, T. Kovarnik, M. Pazdernik

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$a BACKGROUND: There is conflicting evidence on the role of acetylsalicylic acid (ASA) use in the development of cardiac allograft vasculopathy (CAV). METHODS: A nationwide prospective two-center study investigated changes in the coronary artery vasculature by highly automated 3-D optical coherence tomography (OCT) analysis at 1 month and 12 months after heart transplant (HTx). The influence of ASA use on coronary artery microvascular changes was analyzed in the overall study cohort and after propensity score matching for selected clinical CAV risk factors. RESULTS: In total, 175 patients (mean age 52 ± 12 years, 79% male) were recruited. During the 1-year follow-up, both intimal and media thickness progressed, with ASA having no effect on its progression. However, detailed OCT analysis revealed that ASA use was associated with a lower increase in lipid plaque (LP) burden (p = .013), while it did not affect the other observed pathologies. Propensity score matching of 120 patients (60 patient pairs) showed similar results, with ASA use associated with lower progression of LPs (p = .002), while having no impact on layered fibrotic plaque (p = .224), calcification (p = .231), macrophage infiltration (p = .197), or the absolute coronary artery risk score (p = .277). According to Kaplan-Meier analysis, ASA use was not associated with a significant difference in survival (p = .699) CONCLUSION: This study showed a benefit of early ASA use after HTx on LP progression. However, ASA use did not have any impact on the progression of other OCT-observed pathologies or long-term survival.

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$a Wohlfahrt, Peter $u Department of Preventive Cardiology, IKEM, Prague, Czech Republic

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$a Sonka, Milan $u Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, Iowa, USA

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$a Chen, Zhi $u Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, Iowa, USA

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$a Kautzner, Josef $u Department of Cardiology, IKEM, Prague, Czech Republic

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$a Melenovsky, Vojtech $u Department of Cardiology, IKEM, Prague, Czech Republic

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$a Karmazin, Vladimir $u Department of Cardiology, IKEM, Prague, Czech Republic

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$a Bedanova, Helena $u Cardiovascular and Transplantation Surgery, Brno, Czech Republic

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$a Tomasek, Ales $u Cardiovascular and Transplantation Surgery, Brno, Czech Republic

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$a Ozabalova, Eva $u Department of Cardiovascular Diseases, St. Anne's University Hospital and Masaryk University Brno, Brno, Czech Republic

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$a Krejci, Jan $u Department of Cardiovascular Diseases, St. Anne's University Hospital and Masaryk University Brno, Brno, Czech Republic

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$a Kovarnik, Tomas $u 2nd Department of Internal Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic

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$a Pazdernik, Michal $u Department of Cardiology, IKEM, Prague, Czech Republic

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