AIMS: To evaluate glucose control non-inferiority and time benefits of telemedicine follow-up in children with type 1 diabetes (CwD). METHODS: In a single-center 9-month-long randomized controlled study (clinicaltrials.gov NCT05484427), 50 children were randomized to either telemedicine group (TG) followed-up distantly by e-mail, or to face-to-face group (FFG) attending standard personal visits. The primary endpoint was non-inferiority of HbA1c at final visit (level of non-inferiority was set at 5 mmol/mol). The secondary endpoints were subcutaneous glucose monitoring parameters and time consumption from both study subjects' and the physicians' point of view. RESULTS: Non-inferiority of HbA1c in the TG was proven (mean HbA1C 45.8 ± 7.3 [TG] vs. 50.0 ± 12.6 [FFG] mmol/mol, 6.3 vs. 6.7 % DCCT, p = 0.17; between groups HbA1C difference 95 % CI -10.2 to 1.9 mmol/mol). Telemedicine saved time for participants (mean visit duration [MVD] 50 [TG] vs. 247 min [FFG], p < 0.001). There were no other differences between groups neither in CGM parameters nor physician's time consumption (MVD 19 [TG] vs. 20 min [FFG], p = 0.58). CONCLUSIONS: Nine-month telemedicine follow-up of the children with well-controlled T1D is not inferior to standard face-to-face visits. Telemedicine visits saved time for the participants but not for their diabetologists.

Department of Pediatrics of 2nd Faculty of Medicine Charles University Prague and Motol University Hospital 5 Uvalu 84 Prague 15000 Czech Republic

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$a Plachy, Lukas $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: lukas.plachy@fnmotol.cz

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$a Telemedicine maintains good glucose control in children with type 1 diabetes but is not time saving for healthcare professionals: KITES randomized study / $c L. Plachy, V. Neuman, K. Velichova, MG. Slavenko, A. Santova, S. Anne Amaratunga, B. Obermannova, S. Kolouskova, S. Pruhova, Z. Sumnik, L. Petruzelkova

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$a AIMS: To evaluate glucose control non-inferiority and time benefits of telemedicine follow-up in children with type 1 diabetes (CwD). METHODS: In a single-center 9-month-long randomized controlled study (clinicaltrials.gov NCT05484427), 50 children were randomized to either telemedicine group (TG) followed-up distantly by e-mail, or to face-to-face group (FFG) attending standard personal visits. The primary endpoint was non-inferiority of HbA1c at final visit (level of non-inferiority was set at 5 mmol/mol). The secondary endpoints were subcutaneous glucose monitoring parameters and time consumption from both study subjects' and the physicians' point of view. RESULTS: Non-inferiority of HbA1c in the TG was proven (mean HbA1C 45.8 ± 7.3 [TG] vs. 50.0 ± 12.6 [FFG] mmol/mol, 6.3 vs. 6.7 % DCCT, p = 0.17; between groups HbA1C difference 95 % CI -10.2 to 1.9 mmol/mol). Telemedicine saved time for participants (mean visit duration [MVD] 50 [TG] vs. 247 min [FFG], p < 0.001). There were no other differences between groups neither in CGM parameters nor physician's time consumption (MVD 19 [TG] vs. 20 min [FFG], p = 0.58). CONCLUSIONS: Nine-month telemedicine follow-up of the children with well-controlled T1D is not inferior to standard face-to-face visits. Telemedicine visits saved time for the participants but not for their diabetologists.

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$a Neuman, Vit $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: vit.neuman@fnmotol.cz

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$a Velichova, Katerina $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: kacka.velichova@seznam.cz

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$a Slavenko, Matvei G $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: matvei.slavenko@fnmotol.cz

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$a Santova, Alzbeta $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: alzbeta.santova@fnmotol.cz

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$a Anne Amaratunga, Shenali $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: shanali.amaratunga@fnmotol.cz

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$a Obermannova, Barbora $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: barbora.obermannova@fnmotol.cz

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$a Kolouskova, Stanislava $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: stepanka.pruhova@lfmotol.cuni.cz

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$a Pruhova, Stepanka $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: stanislava.kolouskova@lfmotol.cuni.cz

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$a Sumnik, Zdenek $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic. Electronic address: zdenek.sumnik@lfmotol.cuni.cz

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$a Petruzelkova, Lenka $u Department of Pediatrics of Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, V Uvalu 84, Prague, 15000, Czech Republic

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