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G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives
J. Figueiredo, JL. Mergny, C. Cruz
Language English Country Netherlands
Document type Journal Article, Review
- MeSH
- G-Quadruplexes * MeSH
- Humans MeSH
- Ligands MeSH
- Neoplasms * drug therapy MeSH
- Antineoplastic Agents * pharmacology therapeutic use MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these structures promising anti-cancer targets. Compounds able to recognize these structures have been investigated as potential anticancer drugs; however, no G4 binder has yet been approved in the clinic. Here, we describe G4 ligands structure-activity relationships, in vivo effects as well as clinical trials. Addressing G4 ligand characteristics, targeting challenges, and structure-activity relationships, this review provides insights into the development of potent and selective G4-targeting molecules for therapeutic applications.
CICS UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal
Institute of Biophysics of the CAS v v i Královopolská 135 612 65 Brno Czech Republic
References provided by Crossref.org
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- $a Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these structures promising anti-cancer targets. Compounds able to recognize these structures have been investigated as potential anticancer drugs; however, no G4 binder has yet been approved in the clinic. Here, we describe G4 ligands structure-activity relationships, in vivo effects as well as clinical trials. Addressing G4 ligand characteristics, targeting challenges, and structure-activity relationships, this review provides insights into the development of potent and selective G4-targeting molecules for therapeutic applications.
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