• Je něco špatně v tomto záznamu ?

Spoken Language Alterations can Predict Phenoconversion in Isolated Rapid Eye Movement Sleep Behavior Disorder: A Multicenter Study

M. Šubert, M. Novotný, T. Tykalová, J. Hlavnička, P. Dušek, E. Růžička, D. Škrabal, A. Pelletier, RB. Postuma, J. Montplaisir, JF. Gagnon, A. Galbiati, L. Ferini-Strambi, S. Marelli, EK. St Louis, PC. Timm, LN. Teigen, A. Janzen, W. Oertel, B....

. 2024 ; 95 (3) : 530-543. [pub] 20231209

Jazyk angličtina Země Spojené státy americké

Typ dokumentu multicentrická studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24006976

Grantová podpora
CIHR - Canada
CIHR - Canada

OBJECTIVE: This study assessed the relationship between speech and language impairment and outcome in a multicenter cohort of isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: Patients with iRBD from 7 centers speaking Czech, English, German, French, and Italian languages underwent a detailed speech assessment at baseline. Story-tale narratives were transcribed and linguistically annotated using fully automated methods based on automatic speech recognition and natural language processing algorithms, leading to the 3 distinctive linguistic and 2 acoustic patterns of language deterioration and associated composite indexes of their overall severity. Patients were then prospectively followed and received assessments for parkinsonism or dementia during follow-up. The Cox proportional hazard was performed to evaluate the predictive value of language patterns for phenoconversion over a follow-up period of 5 years. RESULTS: Of 180 patients free of parkinsonism or dementia, 156 provided follow-up information. After a mean follow-up of 2.7 years, 42 (26.9%) patients developed neurodegenerative disease. Patients with higher severity of linguistic abnormalities (hazard ratio [HR = 2.35]) and acoustic abnormalities (HR = 1.92) were more likely to develop a defined neurodegenerative disease, with converters having lower content richness (HR = 1.74), slower articulation rate (HR = 1.58), and prolonged pauses (HR = 1.46). Dementia-first (n = 16) and parkinsonism-first with mild cognitive impairment (n = 9) converters had higher severity of linguistic abnormalities than parkinsonism-first with normal cognition converters (n = 17). INTERPRETATION: Automated language analysis might provide a predictor of phenoconversion from iRBD into synucleinopathy subtypes with cognitive impairment, and thus can be used to stratify patients for neuroprotective trials. ANN NEUROL 2024;95:530-543.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24006976
003      
CZ-PrNML
005      
20240423155623.0
007      
ta
008      
240412s2024 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/ana.26835 $2 doi
035    __
$a (PubMed)37997483
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Šubert, Martin $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic $1 https://orcid.org/0000000347108564
245    10
$a Spoken Language Alterations can Predict Phenoconversion in Isolated Rapid Eye Movement Sleep Behavior Disorder: A Multicenter Study / $c M. Šubert, M. Novotný, T. Tykalová, J. Hlavnička, P. Dušek, E. Růžička, D. Škrabal, A. Pelletier, RB. Postuma, J. Montplaisir, JF. Gagnon, A. Galbiati, L. Ferini-Strambi, S. Marelli, EK. St Louis, PC. Timm, LN. Teigen, A. Janzen, W. Oertel, B. Heim, E. Holzknecht, A. Stefani, B. Högl, Y. Dauvilliers, E. Evangelista, K. Šonka, J. Rusz
520    9_
$a OBJECTIVE: This study assessed the relationship between speech and language impairment and outcome in a multicenter cohort of isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). METHODS: Patients with iRBD from 7 centers speaking Czech, English, German, French, and Italian languages underwent a detailed speech assessment at baseline. Story-tale narratives were transcribed and linguistically annotated using fully automated methods based on automatic speech recognition and natural language processing algorithms, leading to the 3 distinctive linguistic and 2 acoustic patterns of language deterioration and associated composite indexes of their overall severity. Patients were then prospectively followed and received assessments for parkinsonism or dementia during follow-up. The Cox proportional hazard was performed to evaluate the predictive value of language patterns for phenoconversion over a follow-up period of 5 years. RESULTS: Of 180 patients free of parkinsonism or dementia, 156 provided follow-up information. After a mean follow-up of 2.7 years, 42 (26.9%) patients developed neurodegenerative disease. Patients with higher severity of linguistic abnormalities (hazard ratio [HR = 2.35]) and acoustic abnormalities (HR = 1.92) were more likely to develop a defined neurodegenerative disease, with converters having lower content richness (HR = 1.74), slower articulation rate (HR = 1.58), and prolonged pauses (HR = 1.46). Dementia-first (n = 16) and parkinsonism-first with mild cognitive impairment (n = 9) converters had higher severity of linguistic abnormalities than parkinsonism-first with normal cognition converters (n = 17). INTERPRETATION: Automated language analysis might provide a predictor of phenoconversion from iRBD into synucleinopathy subtypes with cognitive impairment, and thus can be used to stratify patients for neuroprotective trials. ANN NEUROL 2024;95:530-543.
650    _2
$a lidé $7 D006801
650    12
$a neurodegenerativní nemoci $7 D019636
650    12
$a porucha chování v REM spánku $x diagnóza $7 D020187
650    12
$a parkinsonské poruchy $7 D020734
650    12
$a kognitivní dysfunkce $x diagnóza $7 D060825
650    12
$a demence $7 D003704
655    _2
$a multicentrická studie $7 D016448
655    _2
$a časopisecké články $7 D016428
700    1_
$a Novotný, Michal $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
700    1_
$a Tykalová, Tereza $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
700    1_
$a Hlavnička, Jan $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
700    1_
$a Dušek, Petr $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic $1 https://orcid.org/0000000348779642 $7 jo2013795390
700    1_
$a Růžička, Evžen $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic $1 https://orcid.org/0000000248939661 $7 jo20000074065
700    1_
$a Škrabal, Dominik $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a Pelletier, Amelie $u Department of Neurology, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada $u Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
700    1_
$a Postuma, Ronald B $u Department of Neurology, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada $u Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
700    1_
$a Montplaisir, Jacques $u Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
700    1_
$a Gagnon, Jean-François $u Center for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada
700    1_
$a Galbiati, Andrea $u Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy $u Department of Psychology, "Vita-Salute" San Raffaele University, Milan, Italy $1 https://orcid.org/0000000181321399
700    1_
$a Ferini-Strambi, Luigi $u Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy $u Department of Psychology, "Vita-Salute" San Raffaele University, Milan, Italy $1 https://orcid.org/0000000328675424
700    1_
$a Marelli, Sara $u Sleep Disorders Center, Division of Neuroscience, Ospedale San Raffaele, Università Vita-Salute, Milan, Italy
700    1_
$a St Louis, Erik K $u Mayo Center for Sleep Medicine, and Sleep Behavior and Neurophysiology Research Laboratory, Departments of Neurology and Medicine, Division of Pulmonary and Critical Care Medicine Mayo Clinic College of Medicine and Science Rochester, Rochester, MN, USA $u Mayo Clinic Health System Southwest Wisconsin, La Crosse, WI, USA $1 https://orcid.org/0000000228338826
700    1_
$a Timm, Paul C $u Mayo Center for Sleep Medicine, and Sleep Behavior and Neurophysiology Research Laboratory, Departments of Neurology and Medicine, Division of Pulmonary and Critical Care Medicine Mayo Clinic College of Medicine and Science Rochester, Rochester, MN, USA
700    1_
$a Teigen, Luke N $u Mayo Center for Sleep Medicine, and Sleep Behavior and Neurophysiology Research Laboratory, Departments of Neurology and Medicine, Division of Pulmonary and Critical Care Medicine Mayo Clinic College of Medicine and Science Rochester, Rochester, MN, USA
700    1_
$a Janzen, Annette $u Department of Neurology, Philipps University Marburg, Marburg, Germany
700    1_
$a Oertel, Wolfgang $u Department of Neurology, Philipps University Marburg, Marburg, Germany
700    1_
$a Heim, Beatrice $u Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria $1 https://orcid.org/0000000267493044
700    1_
$a Holzknecht, Evi $u Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
700    1_
$a Stefani, Ambra $u Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria $1 https://orcid.org/0000000342598824
700    1_
$a Högl, Birgit $u Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
700    1_
$a Dauvilliers, Yves $u National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France $1 https://orcid.org/0000000306836506
700    1_
$a Evangelista, Elisa $u National Reference Network for Narcolepsy, Sleep-Wake Disorder Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INSERM, University of Montpellier, Montpellier, France
700    1_
$a Šonka, Karel $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
700    1_
$a Rusz, Jan $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic $u Department of Neurology & ARTORG Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland $1 https://orcid.org/0000000210363054 $7 xx0093732
773    0_
$w MED00000428 $t Annals of neurology $x 1531-8249 $g Roč. 95, č. 3 (2024), s. 530-543
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37997483 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240412 $b ABA008
991    __
$a 20240423155619 $b ABA008
999    __
$a ok $b bmc $g 2081140 $s 1216743
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 95 $c 3 $d 530-543 $e 20231209 $i 1531-8249 $m Annals of neurology $n Ann Neurol $x MED00000428
GRA    __
$p CIHR $2 Canada
GRA    __
$p CIHR $2 Canada
LZP    __
$a Pubmed-20240412

Najít záznam

Citační ukazatele

Možnosti archivace