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Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress

P. Klusackova, L. Lischkova, V. Kolesnikova, T. Navratil, S. Vlckova, Z. Fenclova, J. Schwarz, J. Ondracek, L. Ondrackova, M. Kostejn, S. Dvorackova, A. Rossnerova, M. Pohanka, P. Bradna, V. Zdimal, D. Pelclova

. 2024 ; 19 (3) : 185-198. [pub] 20240126

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24007270

Grantová podpora
GA ČR no. 22-08358S Cooperatio 207041-3 of the Charles University and Czech Science Foundation

Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016-2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019-2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers' personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01); postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH.

Citace poskytuje Crossref.org

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