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Molecular pathology in diagnosis and prognostication of head and neck tumors
A. Skálová, M. Bradová, M. Michal, E. Mosaieby, N. Klubíčková, T. Vaněček, I. Leivo
Language English Country Germany
Document type Journal Article, Review
NLK
ProQuest Central
from 2003-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2011-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 2003-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2003-01-01 to 1 year ago
- MeSH
- Immunohistochemistry MeSH
- Humans MeSH
- Pathology, Molecular * MeSH
- Head and Neck Neoplasms * diagnosis genetics MeSH
- Pathologists MeSH
- Salivary Glands MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Classification of head and neck tumors has evolved in recent decades including a widespread application of molecular testing in tumors of the salivary glands, sinonasal tract, oropharynx, nasopharynx, and soft tissue. Availability of new molecular techniques allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, the expanding spectrum of immunohistochemical markers facilitates a rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined classifications, while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review highlights some principal molecular alterations in head and neck neoplasms presently available to assist pathologists in the practice of diagnosis, prognostication and prediction of response to treatment.
Bioptic Laboratory Ltd Pilsen Czech Republic
Molecular and Genetic Laboratory Bioptic Laboratory Ltd Pilsen Czech Republic
References provided by Crossref.org
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