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Exploring the impact of intensified multiple session tDCS over the left DLPFC on brain function in MCI: a randomized control trial
P. Šimko, M. Pupíková, M. Gajdoš, P. Klobušiaková, V. Vávra, A. Šimo, I. Rektorová
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu randomizované kontrolované studie, časopisecké články
Grantová podpora
NV18-04-00256
Ministerstvo Zdravotnictví Ceské Republiky
NV18-04-00256
Ministerstvo Zdravotnictví Ceské Republiky
NV18-04-00256
Ministerstvo Zdravotnictví Ceské Republiky
NV18-04-00256
Ministerstvo Zdravotnictví Ceské Republiky
NV18-04-00256
Ministerstvo Zdravotnictví Ceské Republiky
21-13462L
Czech Science Foundation grant
21-13462L
Czech Science Foundation grant
21-13462L
Czech Science Foundation grant
21-13462L
Czech Science Foundation grant
LX22NPO5107
European Union - Next Generation EU
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-12-01
- MeSH
- dorsolaterální prefrontální kortex MeSH
- dvojitá slepá metoda MeSH
- kognitivní dysfunkce * terapie MeSH
- krátkodobá paměť fyziologie MeSH
- lidé MeSH
- mozek diagnostické zobrazování MeSH
- prefrontální mozková kůra fyziologie MeSH
- přímá transkraniální stimulace mozku * metody MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
Transcranial direct current stimulation combined with cognitive training (tDCS-cog) represents a promising approach to combat cognitive decline among healthy older adults and patients with mild cognitive impairment (MCI). In this 5-day-long double-blinded randomized trial, we investigated the impact of intensified tDCS-cog protocol involving two trains of stimulation per day on working memory (WM) enhancement in 35 amnestic and multidomain amnestic MCI patients. Specifically, we focused to improve WM tasks relying on top-down attentional control and hypothesized that intensified tDCS would enhance performance of visual object matching task (VOMT) immediately after the stimulation regimen and at a 1-month follow-up. Secondarily, we explored whether the stimulation would augment online visual working memory training. Using fMRI, we aimed to elucidate the neural mechanisms underlying the intervention effects by analyzing BOLD activations during VOMT. Our main finding revealed no superior after-effects of tDCS-cog over the sham on VOMT among individuals with MCI as indicated by insignificant immediate and long-lasting after-effects. Additionally, the tDCS-cog did not enhance online training as predicted. The fMRI analysis revealed brain activity alterations in right insula that may be linked to tDCS-cog intervention. In the study we discuss the insignificant behavioral results in the context of the current evidence in tDCS parameter space and opening the discussion of possible interference between trained cognitive tasks.
Faculty of Medicine Masaryk University Brno Czech Republic
Surgeon General Office of the Slovak Armed Forces Ružomberok Slovak Republic
Citace poskytuje Crossref.org
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