• Je něco špatně v tomto záznamu ?

Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial

S. Poli, J. Mbroh, JC. Baron, AB. Singhal, D. Strbian, C. Molina, R. Lemmens, G. Turc, R. Mikulik, P. Michel, T. Tatlisumak, HJ. Audebert, M. Dichgans, R. Veltkamp, J. Hüsing, H. Graessner, J. Fiehler, J. Montaner, AK. Adeyemi, K. Althaus, JF....

. 2024 ; 19 (1) : 120-126. [pub] 20230818

Jazyk angličtina Země Spojené státy americké

Typ dokumentu protokol klinické studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24007840

RATIONALE: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. AIMS: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion. METHODS AND DESIGN: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial. STUDY OUTCOMES: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted. SAMPLE SIZE: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation. DISCUSSION: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia. TRIAL REGISTRATIONS: ClinicalTrials.gov: NCT03500939; EudraCT: 2017-001355-31.

Center for Rare Diseases Eberhard Karls University Tubingen Germany

Centre Hospital Regional Universitaire de Nancy Nancy France

Coordinating Centre for Clinical Trials University of Heidelberg Heidelberg Germany

Department of Anaesthesia and Critical Care CHU Grenoble Alpes Grenoble France

Department of Anesthesiology and Intensive Care Medicine Eberhard Karls University Tubingen Germany

Department of Brain Sciences Imperial College London London UK

Department of Cardiology Universitatsspital Basel Basel Switzerland

Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden

Department of Diagnostic and Interventional Neuroradiology Eberhard Karls University Tubingen Germany

Department of Diagnostic and Therapeutic Neuroradiology Centre Hospital Regional Universitaire de Nancy Universite de Lorraine INSERM U1254 Nancy France

Department of Infectiology Eberhard Karls University Tuebingen Germany

Department of Neurology Alfried Krupp Hospital Essen Germany

Department of Neurology and Center for Stroke Research Berlin Charite Universitatsmedizin Berlin Berlin Germany

Department of Neurology and Stroke Center Hopital fondation Adolphe de Rothschild Paris France

Department of Neurology and Stroke Eberhard Karls University University Hospital Tubingen Germany

Department of Neurology Boston Medical Center Boston MA USA

Department of Neurology Duke University School of Medicine Durham NC USA

Department of Neurology Ghent University Hospital Ghent Belgium

Department of Neurology GHU Paris Psychiatrie et Neurosciences INSERM U1266 Universite Paris Cite FHU NeuroVasc Paris France

Department of Neurology Heidelberg University Hospital Heidelberg Germany

Department of Neurology Helsinki University Hospital and University of Helsinki Helsinki Finland

Department of Neurology Hopital Sainte Anne Universite de Paris Paris France

Department of Neurology Hospital University de Bellvitge Barcelona Spain

Department of Neurology KSA Kantonsspital Aarau and University of Bern Bern Switzerland

Department of Neurology Ludwig Maximilian University Munich Germany

Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA

Department of Neurology Sahlgrenska University Hospital Gothenburg Sweden

Department of Neurology St Anne's University Hospital Brno and Masaryk University Brno Czech Republic

Department of Neurology St Anne's University Hospital in Brno Faculty of Medicine Masaryk University Brno Czech Republic

Department of Neurology St John's Hospital Vienna Austria

Department of Neurology University Hospital Essen Essen Germany

Department of Neurology University Hospital Hamburg Eppendorf Hamburg Germany

Department of Neurology University Hospital of Ulm Ulm Germany

Department of Neurology University Hospital Schleswig Holstein Kiel Germany

Department of Neurology University Hospitals Leuven Leuven Belgium

Department of Neurology University Medical Center Hamburg Eppendorf Hamburg Germany

Department of Neurology Vall d'Hebron University Hospital Barcelona Spain

Department of Neuroradiology GHU Paris Psychiatrie et Neurosciences INSERM U1266 Universite Paris Cite FHU NeuroVasc Paris France

Department of Neuroradiology University Hospital Hamburg Eppendorf Hamburg Germany

Department of Neurosciences Experimental Neurology KU Leuven University of Leuven Leuven Belgium

Department of Radiology Boston Medical Center Boston MA USA

Department of Vascular and Interventional Radiology Ghent University Hospital Ghent Belgium

Duke Clinical Research Institute Durham NC USA

Duke University School of Medicine Durham NC USA

Eppdata GmbH Hamburg Germany

European Clinical Research Infrastructure Network Paris France

German Center for Neurodegenerative Diseases Munich Germany

German Centre for Cardiovascular Research Munich Germany

Hertie Institute for Clinical Brain Research Eberhard Karls University Tubingen Germany

Hospital Clinico Universitario de Valladolid Valladolid Spain

Inserm U1216 Grenoble Institut Neurosciences Université Grenoble Alpes Grenoble France

Institute for Stroke and Dementia Research University Hospital LMU Munich Munich Germany

International Clinical Research Centre St Anne's University Hospital in Brno Brno Czech Republic

Landeskrebsregister Nordrhein Westfalen Bochum Germany

Munich Cluster for Systems Neurology Munich Germany

Neurology CHU Grenoble Alpes Grenoble France

Neuroradiology MRI Department CHU Grenoble Alpes Grenoble France

Neuroradiology University Hospital Hamburg Eppendorf Hamburg Germany

Neurosciences Cliniques Centre Hospitalier Universitaire Vaudois Lausanne Switzerland

Vall d'Hebron Institut de Recerca Neurovascular Research Lab Barcelona Spain

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24007840
003      
CZ-PrNML
005      
20240626110606.0
007      
ta
008      
240412s2024 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1177/17474930231185275 $2 doi
035    __
$a (PubMed)37515459
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Poli, Sven $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany $u Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tubingen, Germany $1 https://orcid.org/0000000202868781
245    10
$a Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial / $c S. Poli, J. Mbroh, JC. Baron, AB. Singhal, D. Strbian, C. Molina, R. Lemmens, G. Turc, R. Mikulik, P. Michel, T. Tatlisumak, HJ. Audebert, M. Dichgans, R. Veltkamp, J. Hüsing, H. Graessner, J. Fiehler, J. Montaner, AK. Adeyemi, K. Althaus, JF. Arenillas, B. Bender, F. Benedikt, G. Broocks, I. Burghaus, P. Cardona, M. Deb-Chatterji, M. Cviková, L. Defreyne, V. De Herdt, O. Detante, U. Ernemann, F. Flottmann, L. García Guillamón, M. Glauch, A. Gomez-Exposito, B. Gory, S. Sylvie Grand, M. Haršány, TK. Hauser, O. Heck, D. Hemelsoet, F. Hennersdorf, J. Hoppe, P. Kalmbach, L. Kellert, M. Köhrmann, M. Kowarik, B. Lara-Rodríguez, L. Legris, T. Lindig, S. Luntz, J. Lusk, B. Mac Grory, A. Manger, N. Martinez-Majander, A. Mengel, J. Meyne, S. Müller, S. Mundiyanapurath, O. Naggara, K. Nedeltchev, TN. Nguyen, MA. Nilsson, M. Obadia, K. Poli, JC. Purrucker, S. Räty, S. Richard, H. Richter, C. Schilte, E. Schlemm, L. Stöhr, B. Stolte, M. Sykora, G. Thomalla, L. Tomppo, N. van Horn, J. Zeller, U. Ziemann, CS. Zuern, F. Härtig, J. Tuennerhoff, PROOF investigators
520    9_
$a RATIONALE: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. AIMS: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion. METHODS AND DESIGN: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial. STUDY OUTCOMES: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted. SAMPLE SIZE: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation. DISCUSSION: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia. TRIAL REGISTRATIONS: ClinicalTrials.gov: NCT03500939; EudraCT: 2017-001355-31.
650    _2
$a lidé $7 D006801
650    12
$a ischemie mozku $x komplikace $7 D002545
650    12
$a endovaskulární výkony $x metody $7 D057510
650    12
$a ischemická cévní mozková příhoda $x komplikace $x diagnóza $7 D000083242
650    _2
$a multicentrické studie jako téma $7 D015337
650    _2
$a kyslík $x terapeutické užití $7 D010100
650    _2
$a kvalita života $7 D011788
650    _2
$a trombektomie $x metody $7 D017131
650    _2
$a výsledek terapie $7 D016896
650    _2
$a klinické zkoušky, fáze II jako téma $7 D017322
655    _2
$a protokol klinické studie $7 D000078325
655    _2
$a časopisecké články $7 D016428
700    1_
$a Mbroh, Joshua $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Baron, Jean-Claude $u Department of Neurology, Hopital Sainte-Anne, Universite de Paris, Paris, France
700    1_
$a Singhal, Aneesh B $u Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
700    1_
$a Strbian, Daniel $u Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
700    1_
$a Molina, Carlos $u Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain
700    1_
$a Lemmens, Robin $u Department of Neurosciences, Experimental Neurology, KU Leuven, University of Leuven, Leuven, Belgium $u Department of Neurology, University Hospitals Leuven, Leuven, Belgium
700    1_
$a Turc, Guillaume $u Department of Neurology, Hopital Sainte-Anne, Universite de Paris, Paris, France $u Department of Neurology, GHU Paris Psychiatrie et Neurosciences INSERM U1266 Universite Paris Cite FHU NeuroVasc, Paris, France $1 https://orcid.org/0000000150594095
700    1_
$a Mikulik, Robert $u Department of Neurology, St. Anne's University Hospital Brno and Masaryk University, Brno, Czech Republic
700    1_
$a Michel, Patrik $u Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland $1 https://orcid.org/0000000349547579
700    1_
$a Tatlisumak, Turgut $u Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland $u Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden $u Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
700    1_
$a Audebert, Heinrich J $u Department of Neurology and Center for Stroke Research Berlin, Charite Universitatsmedizin Berlin, Berlin, Germany $1 https://orcid.org/0000000247850366
700    1_
$a Dichgans, Martin $u Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany $u Munich Cluster for Systems Neurology (SyNergy), Munich, Germany $u German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany $u German Centre for Cardiovascular Research (DZHK, Munich), Munich, Germany
700    1_
$a Veltkamp, Roland $u Department of Neurology, Alfried Krupp Hospital, Essen, Germany $u Department of Brain Sciences, Imperial College London, London, UK
700    1_
$a Hüsing, Johannes $u Coordinating Centre for Clinical Trials, University of Heidelberg, Heidelberg, Germany $u Landeskrebsregister Nordrhein-Westfalen, Bochum, Germany
700    1_
$a Graessner, Holm $u Center for Rare Diseases, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Fiehler, Jens $u Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany $u Eppdata GmbH, Hamburg, Germany
700    1_
$a Montaner, Joan $u Vall d'Hebron Institut de Recerca, Neurovascular Research Lab, Barcelona, Spain
700    1_
$a Adeyemi, Adedolapo Kamaldeen $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Althaus, Katharina $u Department of Neurology, University Hospital of Ulm, Ulm, Germany $1 https://orcid.org/0000000290044335
700    1_
$a Arenillas, Juan F $u Hospital Clinico Universitario de Valladolid, Valladolid, Spain $1 https://orcid.org/0000000174646101
700    1_
$a Bender, Benjamin $u Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls University, Tubingen, Germany $1 https://orcid.org/0000000232054631
700    1_
$a Benedikt, Frank $u Department of Neurology, University Hospital Essen, Essen, Germany
700    1_
$a Broocks, Gabriel $u Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany $1 https://orcid.org/0000000275759850
700    1_
$a Burghaus, Ina $u Coordinating Centre for Clinical Trials, University of Heidelberg, Heidelberg, Germany
700    1_
$a Cardona, Pere $u Department of Neurology, Hospital University de Bellvitge, Barcelona, Spain
700    1_
$a Deb-Chatterji, Milani $u Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
700    1_
$a Cabúková, Martina, $u Department of Neurology, St. Anne's University Hospital in Brno, Faculty of Medicine Masaryk University, Brno, Czech Republic $d 1990- $7 xx0319341
700    1_
$a Defreyne, Luc $u Department of Vascular and Interventional Radiology, Ghent University Hospital, Ghent, Belgium
700    1_
$a De Herdt, Veerle $u Department of Neurology, Ghent University Hospital, Ghent, Belgium
700    1_
$a Detante, Olivier $u Neurology, CHU Grenoble Alpes, Grenoble, France $u Inserm, U1216, Grenoble Institut Neurosciences, Université Grenoble Alpes, Grenoble, France
700    1_
$a Ernemann, Ulrike $u Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Flottmann, Fabian $u Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany $1 https://orcid.org/0000000183588089
700    1_
$a García Guillamón, Lídia $u Vall d'Hebron Institut de Recerca, Neurovascular Research Lab, Barcelona, Spain
700    1_
$a Glauch, Monika $u Center for Rare Diseases, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Gomez-Exposito, Alexandra $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Gory, Benjamin $u Department of Diagnostic and Therapeutic Neuroradiology, Centre Hospital Regional Universitaire de Nancy, Universite de Lorraine, INSERM U1254, Nancy, France
700    1_
$a Sylvie Grand, Sylvie $u Inserm, U1216, Grenoble Institut Neurosciences, Université Grenoble Alpes, Grenoble, France $u Neuroradiology / MRI Department, CHU Grenoble Alpes, Grenoble, France
700    1_
$a Haršány, Michal $u Department of Neurology, St. Anne's University Hospital in Brno, Faculty of Medicine Masaryk University, Brno, Czech Republic $u International Clinical Research Centre, St. Anne's University Hospital in Brno, Brno, Czech Republic
700    1_
$a Hauser, Till Karsten $u Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Heck, Olivier $u Neuroradiology / MRI Department, CHU Grenoble Alpes, Grenoble, France
700    1_
$a Hemelsoet, Dimitri $u Department of Neurology, Ghent University Hospital, Ghent, Belgium
700    1_
$a Hennersdorf, Florian $u Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Hoppe, Julia $u Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
700    1_
$a Kalmbach, Pia $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Kellert, Lars $u Department of Neurology, Ludwig Maximilian University (LMU), Munich, Germany
700    1_
$a Köhrmann, Martin $u Department of Neurology, University Hospital Essen, Essen, Germany
700    1_
$a Kowarik, Markus $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany $u Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Lara-Rodríguez, Blanca $u Department of Neurology, Hospital University de Bellvitge, Barcelona, Spain
700    1_
$a Legris, Loic $u Neurology, CHU Grenoble Alpes, Grenoble, France $u Inserm, U1216, Grenoble Institut Neurosciences, Université Grenoble Alpes, Grenoble, France $1 https://orcid.org/0000000166974519
700    1_
$a Lindig, Tobias $u Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Luntz, Steffen $u Coordinating Centre for Clinical Trials, University of Heidelberg, Heidelberg, Germany
700    1_
$a Lusk, Jay $u Duke University School of Medicine, Durham, NC, USA
700    1_
$a Mac Grory, Brian $u Duke University School of Medicine, Durham, NC, USA $u Duke Clinical Research Institute, Durham, NC, USA $u Department of Neurology, Duke University School of Medicine, Durham, NC, USA
700    1_
$a Manger, Andreas $u Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Martinez-Majander, Nicolas $u Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
700    1_
$a Mengel, Annerose $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Meyne, Johannes $u Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany
700    1_
$a Müller, Susanne $u Department of Neurology, University Hospital of Ulm, Ulm, Germany
700    1_
$a Mundiyanapurath, Sibu $u Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
700    1_
$a Naggara, Olivier $u Department of Neuroradiology, GHU Paris Psychiatrie et Neurosciences INSERM U1266 Universite Paris Cite FHU NeuroVasc, Paris, France
700    1_
$a Nedeltchev, Krassen $u Department of Neurology, KSA Kantonsspital Aarau and University of Bern, Bern, Switzerland
700    1_
$a Nguyen, Thanh N $u Department of Radiology, Boston Medical Center, Boston, MA, USA $u Department of Neurology, Boston Medical Center, Boston, MA, USA $1 https://orcid.org/0000000228101685
700    1_
$a Nilsson, Maike A $u Coordinating Centre for Clinical Trials, University of Heidelberg, Heidelberg, Germany
700    1_
$a Obadia, Michael $u Department of Neurology and Stroke Center, Hopital fondation Adolphe de Rothschild, Paris, France
700    1_
$a Poli, Khouloud $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Purrucker, Jan C $u Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
700    1_
$a Räty, Silja $u Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland $1 https://orcid.org/0000000269210597
700    1_
$a Richard, Sebastien $u Centre Hospital Regional Universitaire de Nancy, Nancy, France
700    1_
$a Richter, Hardy $u Department of Infectiology, Eberhard-Karls-University, Tuebingen, Germany
700    1_
$a Schilte, Clotilde $u Department of Anaesthesia and Critical Care, CHU Grenoble Alpes, Grenoble, France
700    1_
$a Schlemm, Eckhard $u Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany $1 https://orcid.org/0000000257292935
700    1_
$a Stöhr, Linda $u European Clinical Research Infrastructure Network (ECRIN), Paris, France
700    1_
$a Stolte, Benjamin $u Department of Neurology, University Hospital Essen, Essen, Germany
700    1_
$a Sykora, Marek $u Department of Neurology, St. John's Hospital, Vienna, Austria
700    1_
$a Thomalla, Götz $u Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
700    1_
$a Tomppo, Liisa $u Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
700    1_
$a van Horn, Noel $u Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany $1 https://orcid.org/0000000157641982
700    1_
$a Zeller, Julia $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany
700    1_
$a Ziemann, Ulf $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany $u Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Zuern, Christine S $u Department of Cardiology, Universitatsspital Basel, Basel, Switzerland
700    1_
$a Härtig, Florian $u Department of Anesthesiology and Intensive Care Medicine, Eberhard-Karls University, Tubingen, Germany
700    1_
$a Tuennerhoff, Johannes $u Department of Neurology & Stroke, Eberhard-Karls University, University Hospital, Tubingen, Germany $u Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tubingen, Germany $1 https://orcid.org/000000015381839X
710    2_
$a PROOF investigators
773    0_
$w MED00176295 $t International journal of stroke $x 1747-4949 $g Roč. 19, č. 1 (2024), s. 120-126
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37515459 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240412 $b ABA008
991    __
$a 20240626110601 $b ABA008
999    __
$a ok $b bmc $g 2081693 $s 1217607
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 19 $c 1 $d 120-126 $e 20230818 $i 1747-4949 $m International journal of stroke $n Int J Stroke $x MED00176295
LZP    __
$a Pubmed-20240412

Najít záznam

Citační ukazatele

Možnosti archivace