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Disease burden, clinical management and unmet treatment need of patients with moderate to severe alopecia areata; consensus statements, insights, and practices from CERTAAE (Central/Eastern EU, Russia, Türkiye AA experts) Delphi panel
L. Rudnicka, M. Trzeciak, E. Alpsoy, P. Arenberger, S. Alper, N. Benáková, S. Bobko, M. Borlu, M. Czarnecka Operacz, B. Engin, T. Ergun, IE. Sağduyu, O. Filipovská, A. Gadzhigoroeva, M. Kojanová, A. Lesiak, A. Michenko, N. Murashkin, N. Onsun, W....
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2014
Free Medical Journals
od 2014
PubMed Central
od 2014
Europe PubMed Central
od 2014
Open Access Digital Library
od 2014-01-01
Open Access Digital Library
od 2014-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2014
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: This study aims to update the understanding of Alopecia Areata (AA) in Poland, Czechia, Russia, and Türkiye, focusing on the disease burden, clinical management, and patient journey. It seeks to establish a consensus on optimal management strategies for AA in these regions. METHODS: A modified 2-round Delphi panel was conveyed with 23 Dermatologists (Russia; 4, Türkiye; 7, Poland; 6, and Czechia; 6). The Delphi questionnaire consisted of 61 statements and 43 questions designed to obtain an overall understanding of the perception and acceptance of available information regarding the care of patients with alopecia areata. RESULTS: The study revealed that moderate-to-severe AA significantly impacts patients' and their families' QoL, consistent with previous studies. AA was found to cause more substantial impairment when additional lesions appeared in visible areas besides the scalp. Work and productivity impairment were notably higher in adults with moderate-to-severe AA. Diagnostic consensus highlighted the importance of skin biopsies and trichoscopy, while the need for more practical severity scoring systems was emphasized. Current treatments, including topical therapies, corticosteroids, and systemic immune modifiers, were deemed insufficient, highlighting the unmet medical need. CONCLUSION: The Delphi study underscores a significant disease burden and unmet medical needs in patients with moderate-to-severe AA. It highlights the necessity of access to novel treatments and further research to develop more effective therapies with a tolerable safety profile. The findings align with global research, emphasizing the psychosocial impact of AA and the need for standardized, effective treatment protocols.
Department of Dermatology and Venereology Akdeniz University School of Medicine Antalya Türkiye
Department of Dermatology and Venereology Koç University İstanbul Türkiye
Department of Dermatology Ege University Izmir Türkiye
Department of Dermatology Hospital AGEL Novy Jicin JSC Novy Jicin Czechia
Department of Dermatology Marmara University İstanbul Türkiye
Department of Dermatology Masaryk Hospital in Ústí nad Labem Ústí nad Labem Czechia
Department of Dermatology Medical University of Poznań Poznań Poland
Department of Dermatology Medical University of Warsaw Warsaw Poland
Department of Dermatology Military Institute of Medicine Warsaw Poland
Department of Dermatology University of Rzeszów Rzeszów Poland
Department of Dermatology Venereology and Allergology Medical University of Gdańsk Gdańsk Poland
Department of Dermatovenereology 1st Faculty of Medicine Charles University Prague Czechia
Department of Dermatovenerology 3rd Faculty of Medicine Charles University Prague Czechia
Dermatology and Venereology Department Erciyes University Kayseri Türkiye
Dermatology Department Bezmialem Vakıf University İstanbul Türkiye
Medical Affairs Pfizer İstanbul Türkiye
Medical Research and Educational Center Lomonosov Moscow State University Moscow Russia
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology Moscow Russia
Moscow Scientific and Practical Centre of Dermatovenereology and Cosmetology Moscow Russia
National Medical Research Center for Children's Health Moscow Russia
Citace poskytuje Crossref.org
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- $a Disease burden, clinical management and unmet treatment need of patients with moderate to severe alopecia areata; consensus statements, insights, and practices from CERTAAE (Central/Eastern EU, Russia, Türkiye AA experts) Delphi panel / $c L. Rudnicka, M. Trzeciak, E. Alpsoy, P. Arenberger, S. Alper, N. Benáková, S. Bobko, M. Borlu, M. Czarnecka Operacz, B. Engin, T. Ergun, IE. Sağduyu, O. Filipovská, A. Gadzhigoroeva, M. Kojanová, A. Lesiak, A. Michenko, N. Murashkin, N. Onsun, W. Owczarek, Z. Plzakova, A. Reich, M. Selerová, BA. Gürbüz
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- $a OBJECTIVES: This study aims to update the understanding of Alopecia Areata (AA) in Poland, Czechia, Russia, and Türkiye, focusing on the disease burden, clinical management, and patient journey. It seeks to establish a consensus on optimal management strategies for AA in these regions. METHODS: A modified 2-round Delphi panel was conveyed with 23 Dermatologists (Russia; 4, Türkiye; 7, Poland; 6, and Czechia; 6). The Delphi questionnaire consisted of 61 statements and 43 questions designed to obtain an overall understanding of the perception and acceptance of available information regarding the care of patients with alopecia areata. RESULTS: The study revealed that moderate-to-severe AA significantly impacts patients' and their families' QoL, consistent with previous studies. AA was found to cause more substantial impairment when additional lesions appeared in visible areas besides the scalp. Work and productivity impairment were notably higher in adults with moderate-to-severe AA. Diagnostic consensus highlighted the importance of skin biopsies and trichoscopy, while the need for more practical severity scoring systems was emphasized. Current treatments, including topical therapies, corticosteroids, and systemic immune modifiers, were deemed insufficient, highlighting the unmet medical need. CONCLUSION: The Delphi study underscores a significant disease burden and unmet medical needs in patients with moderate-to-severe AA. It highlights the necessity of access to novel treatments and further research to develop more effective therapies with a tolerable safety profile. The findings align with global research, emphasizing the psychosocial impact of AA and the need for standardized, effective treatment protocols.
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