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Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy
H. Kopřivová, K. Kiss, L. Krbal, V. Stejskal, J. Buday, P. Pořízka, M. Kaška, A. Ryška, J. Kaiser
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- hořčík * analýza MeSH
- lasery * MeSH
- lidé MeSH
- melanom * patologie diagnostické zobrazování diagnóza chemie MeSH
- nádory kůže * patologie diagnostické zobrazování MeSH
- spektrální analýza * metody MeSH
- vápník analýza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The diagnosis of malignant melanoma, often an inconspicuous but highly aggressive tumor, is most commonly done by histological examination, while additional diagnostic methods on the level of elements and molecules are constantly being developed. Several studies confirmed differences in the chemical composition of healthy and tumor tissue. Our study presents the potential of the LIBS (Laser-Induced-Breakdown Spectroscopy) technique as a diagnostic tool in malignant melanoma (MM) based on the quantitative changes in elemental composition in cancerous tissue. Our patient group included 17 samples of various types of malignant melanoma and one sample of healthy skin tissue as a control. To achieve a clear perception of results, we have selected two biogenic elements (calcium and magnesium), which showed a dissimilar distribution in cancerous tissue from its healthy surroundings. Moreover, we observed indications of different concentrations of these elements in different subtypes of malignant melanoma, a hypothesis that requires confirmation in a more extensive sample set. The information provided by the LIBS Imaging method could potentially be helpful not only in the diagnostics of tumor tissue but also be beneficial in broadening the knowledge about the tumor itself.
Citace poskytuje Crossref.org
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- $a Kopřivová, Hana $u Central European Institute of Technology (CEITEC), Brno University of Technology, Purkyňova 123, 612 00, Brno, Czech Republic
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- $a The diagnosis of malignant melanoma, often an inconspicuous but highly aggressive tumor, is most commonly done by histological examination, while additional diagnostic methods on the level of elements and molecules are constantly being developed. Several studies confirmed differences in the chemical composition of healthy and tumor tissue. Our study presents the potential of the LIBS (Laser-Induced-Breakdown Spectroscopy) technique as a diagnostic tool in malignant melanoma (MM) based on the quantitative changes in elemental composition in cancerous tissue. Our patient group included 17 samples of various types of malignant melanoma and one sample of healthy skin tissue as a control. To achieve a clear perception of results, we have selected two biogenic elements (calcium and magnesium), which showed a dissimilar distribution in cancerous tissue from its healthy surroundings. Moreover, we observed indications of different concentrations of these elements in different subtypes of malignant melanoma, a hypothesis that requires confirmation in a more extensive sample set. The information provided by the LIBS Imaging method could potentially be helpful not only in the diagnostics of tumor tissue but also be beneficial in broadening the knowledge about the tumor itself.
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- $a Kiss, Kateřina $u Charles University, Faculty of Medicine in Hradec Kralove, Šimkova 870, 500 03, Hradec Králové, Czech Republic; Charles University, Third Faculty of Medicine, Department of Plastic Surgery, Ruská 2411, 100 00, Praha 10, Czech Republic; Surgical Department, University Hospital Hradec Králové, Sokolská 571, 500 05, Hradec Králové, Czech Republic
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