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Hodgkin lymphoma: hypodense lesions in mediastinal masses
A. Damek, L. Kurch, FC. Franke, A. Attarbaschi, A. Beishuizen, M. Cepelova, F. Ceppi, S. Daw, K. Dieckmann, A. Fernández-Teijeiro, T. Feuchtinger, JE. Flerlage, A. Fosså, TW. Georgi, D. Hasenclever, A. Hraskova, J. Karlen, T. Klekawka, R. Kluge,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
- MeSH
- doba přežití bez progrese choroby MeSH
- dospělí MeSH
- fluorodeoxyglukosa F18 MeSH
- Hodgkinova nemoc * patologie diagnostické zobrazování MeSH
- lidé středního věku MeSH
- lidé MeSH
- mediastinum patologie diagnostické zobrazování MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádory mediastina * patologie diagnostické zobrazování MeSH
- počítačová rentgenová tomografie MeSH
- pozitronová emisní tomografie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p < 0.001). Patients with total HDV > 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.
Department of Medical Oncology and Radiotherapy Oslo University Hospital Oslo Norway
Department of Nuclear Medicine University of Leipzig Leipzig Germany
Department of Oncology St Jude Children's Research Hospital Memphis TN USA
Department of Pediatric Hematology and Oncology Justus Liebig University Gießen Germany
Department of Pediatric Hematology and Oncology Our Lady's Children's Hospital Dublin Ireland
Department of Pediatric Hematology and Oncology University Children's Hospital Bratislava Slovakia
Department of Pediatric Hematology and Oncology University College London Hospitals London UK
Department of Pediatric Hematology and Oncology University Hospitals Leuven Leuven Belgium
Department of Radiation Oncology Medical Faculty of the Martin Luther University Halle Germany
Department of Radiation Oncology University Hospital Vienna Vienna Austria
Erasmus MC Sophia Children's Hospital Rotterdam The Netherlands
Hôpital Armand Trousseau Sorbonne Universitè Paris France
Institute of Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Institute of Pediatrics Jagiellonian University Medical College Krakow Poland
Karolinska University Hospital Astrid Lindgrens Childrens Hospital Stockholm Sweden
Pediatric Onco Hematology Unit Hospital Universitario Virgen Macarena Sevilla Spain
Princess Màxima Center for Pediatric Oncology Utrecht The Netherlands
Service d'Hématologie Pédiatrique Hôpital Robert Debré Paris France
Citace poskytuje Crossref.org
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