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Two cases with discrepancy in the quantitative cytological assessment of cerebrospinal fluid in neonatal samples using light microscopy in comparison with Sysmex XN-1000
P. Broz, S. Kukralova, J. Palatova, K. Kolduskova, J. Zenkova, D. Rajdl, J. Racek
Language English Country Croatia
Document type Case Reports, Comparative Study
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- MeSH
- Leukocytes, Mononuclear pathology cytology MeSH
- Humans MeSH
- Microscopy * methods MeSH
- Cerebrospinal Fluid cytology MeSH
- Neutrophils cytology pathology MeSH
- Infant, Newborn MeSH
- Leukocyte Count MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Comparative Study MeSH
We present two cases from the neonatal department with cerebrospinal fluid examination. We revealed a striking discrepancy in polymorphonuclear (PMN) and mononuclear (MN) cell counts using conventional light microscopy in comparison with automated analyzer Sysmex XN-1000 (PMNs - 13 vs. 173x106/L, MNs - 200 vs. 67x106/L in case 1 and PMNs - 13 vs. 372x106/L, MNs - 411 vs. 179x106/L in case 2). We revealed the dominant presence of hemosiderophages in both cases in cytospin slide. Even though Sysmex XN-1000 offers fast examination with a low sample volume, there is possibility of misdiagnosis, with negative impact on the patient.
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