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Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review
U. Shashikumar, A. Saraswat, K. Deshmukh, CM. Hussain, P. Chandra, PC. Tsai, PC. Huang, YH. Chen, LY. Ke, YC. Lin, S. Chawla, VK. Ponnusamy
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, přehledy
- MeSH
- 3D tisk MeSH
- bioprinting metody MeSH
- buněčné kultury MeSH
- hydrogely * chemie MeSH
- lékové transportní systémy MeSH
- lidé MeSH
- techniky 3D buněčné kultury metody MeSH
- tkáňové inženýrství * metody MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Repairing and regenerating damaged tissues or organs, and restoring their functioning has been the ultimate aim of medical innovations. 'Reviving healthcare' blends tissue engineering with alternative techniques such as hydrogels, which have emerged as vital tools in modern medicine. Additive manufacturing (AM) is a practical manufacturing revolution that uses building strategies like molding as a viable solution for precise hydrogel manufacturing. Recent advances in this technology have led to the successful manufacturing of hydrogels with enhanced reproducibility, accuracy, precision, and ease of fabrication. Hydrogels continue to metamorphose as the vital compatible bio-ink matrix for AM. AM hydrogels have paved the way for complex 3D/4D hydrogels that can be loaded with drugs or cells. Bio-mimicking 3D cell cultures designed via hydrogel-based AM is a groundbreaking in-vivo assessment tool in biomedical trials. This brief review focuses on preparations and applications of additively manufactured hydrogels in the biomedical spectrum, such as targeted drug delivery, 3D-cell culture, numerous regenerative strategies, biosensing, bioprinting, and cancer therapies. Prevalent AM techniques like extrusion, inkjet, digital light processing, and stereo-lithography have been explored with their setup and methodology to yield functional hydrogels. The perspectives, limitations, and the possible prospects of AM hydrogels have been critically examined in this study.
Center for Emerging Contaminants Research National Sun Yat sen University Kaohsiung City 804 Taiwan
Department of Chemistry Amity Institute of Applied Sciences Amity University Noida UP India
Department of Chemistry National Sun Yat sen University Kaohsiung City 804 Taiwan
Department of Medical Research China Medical University Hospital Taichung City Taiwan
Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung City 807 Taiwan
Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung City 807 Taiwan
Institute of Environmental Engineering National Sun Yat sen University Kaohsiung City 804 Taiwan
Citace poskytuje Crossref.org
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- $a Shashikumar, Uday $u Department of Medicinal and Applied Chemistry, Kaohsiung Medical University (KMU), Kaohsiung City 807, Taiwan
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- $a Repairing and regenerating damaged tissues or organs, and restoring their functioning has been the ultimate aim of medical innovations. 'Reviving healthcare' blends tissue engineering with alternative techniques such as hydrogels, which have emerged as vital tools in modern medicine. Additive manufacturing (AM) is a practical manufacturing revolution that uses building strategies like molding as a viable solution for precise hydrogel manufacturing. Recent advances in this technology have led to the successful manufacturing of hydrogels with enhanced reproducibility, accuracy, precision, and ease of fabrication. Hydrogels continue to metamorphose as the vital compatible bio-ink matrix for AM. AM hydrogels have paved the way for complex 3D/4D hydrogels that can be loaded with drugs or cells. Bio-mimicking 3D cell cultures designed via hydrogel-based AM is a groundbreaking in-vivo assessment tool in biomedical trials. This brief review focuses on preparations and applications of additively manufactured hydrogels in the biomedical spectrum, such as targeted drug delivery, 3D-cell culture, numerous regenerative strategies, biosensing, bioprinting, and cancer therapies. Prevalent AM techniques like extrusion, inkjet, digital light processing, and stereo-lithography have been explored with their setup and methodology to yield functional hydrogels. The perspectives, limitations, and the possible prospects of AM hydrogels have been critically examined in this study.
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